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Irf8
Gene Detail
 Symbol
Name
ID
Irf8
interferon regulatory factor 8
MGI:96395
Synonyms ICSBP, Icsbp1, IRF-8, Myls
Feature Type protein coding gene
Genetic Map
Chromosome 8
70.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr8:120736358-120756694 bp, + strand
From VEGA annotation of GRCm38

  20337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:1629  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf8
Human
homologs
Human Homolog IRF8, interferon regulatory factor 8
NCBI Gene ID 3394
neXtProt AC  NX_Q02556
Human Synonyms  H-ICSBP, ICSBP, ICSBP1, IRF-8
Human Chr (Location)  16q24.1; chr16:85932774-85956212 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(7) : Targeted(5) Spontaneous(1) Chemically induced(1)
 
Homozygotes for a targeted null mutation exhibit increased incidence of viral infections, shortened life span, deregulated hematopoiesis, and hematological neoplasias. Heterozygotes show similar, but milder, phenotypes.
 
Human Diseases Modeled Using Mouse Irf8 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications 		All GO classifications: (22 annotations)
Process cellular response to lipopolysaccharide, defense response to bacterium, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression Literature Summary: (8 records)
Data Summary: Results (199)    Tissues (157)    Images (18)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 180
Western blot 2
RT-PCR 17
cDNA source data(90)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(96) Genomic(3) cDNA(90) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033858 (Evidence)
Ensembl Gene ModelENSMUSG00000041515 (Evidence)
Entrez Gene15900 (Evidence)
UniGene334861
DFCITC1572080, TC1677434
DoTSDT.110893431, DT.534022
NIA Mouse Gene IndexU009890
Consensus CDS ProjectCCDS22721.1
International Mouse Knockout Project StatusIrf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033858 VEGA Gene Model | MGI Sequence Detail 20337 C57BL/6J ±  kb
transcript OTTMUST00000085323 VEGA | MGI Sequence Detail 2270 Not Applicable 
polypeptide OTTMUSP00000046088 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(2) UniProt(10)
Polymorphisms RFLP(2) : SNPs(73 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology PR:000002050 interferon regulatory factor 8
References (Earliest) J:17559 Driggers PH, et al., An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990 May;87(10):3743-7
(Latest) J:194543 Baccala R, et al., Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2940-5
All references(136)
Other
accession IDs 		MGD-MRK-11151, MGI:2142648, MGI:3574547
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory