GO Annotations Graph

• Symbol: Clock
• Name: clock circadian regulator
• ID: MGI:99698

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:209614
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IC	J:87263
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180477
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:188853
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:76640
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISA	J:72921
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:178280
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0070888	E-box binding	IDA	J:165365
Molecular Function	GO:0070888	E-box binding	IDA	J:154880
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:271702
Molecular Function	GO:0070888	E-box binding	IDA	J:162974
Molecular Function	GO:0070888	E-box binding	IDA	J:206921
Molecular Function	GO:0070888	E-box binding	IBA	J:265628
Molecular Function	GO:0004402	histone acetyltransferase activity	ISO	J:164563
Molecular Function	GO:0004402	histone acetyltransferase activity	IMP	J:148217
Molecular Function	GO:0004402	histone acetyltransferase activity	TAS	Reactome:R-NUL-4568946
Molecular Function	GO:0005515	protein binding	IPI	J:204645
Molecular Function	GO:0005515	protein binding	IPI	J:201135
Molecular Function	GO:0005515	protein binding	IPI	J:143808
Molecular Function	GO:0005515	protein binding	IPI	J:196684
Molecular Function	GO:0005515	protein binding	IPI	J:196684
Molecular Function	GO:0005515	protein binding	IPI	J:213082
Molecular Function	GO:0005515	protein binding	IPI	J:177241
Molecular Function	GO:0005515	protein binding	IPI	J:272534
Molecular Function	GO:0005515	protein binding	IPI	J:186089
Molecular Function	GO:0005515	protein binding	IPI	J:176119
Molecular Function	GO:0005515	protein binding	IPI	J:245363
Molecular Function	GO:0005515	protein binding	IPI	J:139296
Molecular Function	GO:0005515	protein binding	IPI	J:139296
Molecular Function	GO:0005515	protein binding	IPI	J:173532
Molecular Function	GO:0005515	protein binding	IPI	J:139295
Molecular Function	GO:0005515	protein binding	IPI	J:245363
Molecular Function	GO:0005515	protein binding	IPI	J:87576
Molecular Function	GO:0005515	protein binding	IPI	J:173042
Molecular Function	GO:0005515	protein binding	IPI	J:211243
Molecular Function	GO:0005515	protein binding	IPI	J:188853
Molecular Function	GO:0005515	protein binding	IPI	J:116444
Molecular Function	GO:0005515	protein binding	IPI	J:215875
Molecular Function	GO:0005515	protein binding	IPI	J:215875
Molecular Function	GO:0005515	protein binding	IPI	J:130591
Molecular Function	GO:0005515	protein binding	IPI	J:130591
Molecular Function	GO:0005515	protein binding	IPI	J:215875
Molecular Function	GO:0005515	protein binding	IPI	J:111071
Molecular Function	GO:0005515	protein binding	IPI	J:49044
Molecular Function	GO:0005515	protein binding	IPI	J:160776
Molecular Function	GO:0005515	protein binding	IPI	J:215957
Molecular Function	GO:0005515	protein binding	IPI	J:209570
Molecular Function	GO:0005515	protein binding	IPI	J:227468
Molecular Function	GO:0005515	protein binding	IPI	J:189932
Molecular Function	GO:0005515	protein binding	IPI	J:205048
Molecular Function	GO:0005515	protein binding	IPI	J:200511
Molecular Function	GO:0005515	protein binding	IPI	J:282602
Molecular Function	GO:0005515	protein binding	IPI	J:245381
Molecular Function	GO:0005515	protein binding	IPI	J:200511
Molecular Function	GO:0005515	protein binding	IPI	J:245381
Molecular Function	GO:0005515	protein binding	IPI	J:209477
Molecular Function	GO:0005515	protein binding	IPI	J:189804
Molecular Function	GO:0005515	protein binding	IPI	J:199092
Molecular Function	GO:0005515	protein binding	IPI	J:167924
Molecular Function	GO:0005515	protein binding	IPI	J:148217
Molecular Function	GO:0005515	protein binding	IPI	J:250437
Molecular Function	GO:0005515	protein binding	IPI	J:188853
Molecular Function	GO:0005515	protein binding	IPI	J:109095
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:147991
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:213082
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:201135
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:178280
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:205586
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:211236
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:215875
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:217260
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:176743
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:209477
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	ISA	J:72921
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0033391	chromatoid body	IDA	J:189932
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	IPI	J:245363
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	ISO	J:164563
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	IPI	J:188853
Cellular Component	GO:1990513	CLOCK-BMAL transcription complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:215866
Cellular Component	GO:0005737	cytoplasm	IDA	J:211243
Cellular Component	GO:0005737	cytoplasm	IDA	J:84699
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-508619
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-508656
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-549451
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5667072
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-4568946
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-508656
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-508741
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663114
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663129
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663146
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663147
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663158
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663161
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663169
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663172
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663185
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5663189
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-5669295
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8878686
Cellular Component	GO:0005634	nucleus	IDA	J:188853
Cellular Component	GO:0005634	nucleus	IDA	J:245363
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:211243
Cellular Component	GO:0005634	nucleus	IDA	J:204645
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:139296
Cellular Component	GO:0005634	nucleus	IDA	J:84699
Cellular Component	GO:0005726	perichromatin fibrils	ISO	J:155856
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:188853
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:109095
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:73065
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:147991
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:87263
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:271702
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:199564
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:188853
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:165365
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:178280
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:176743
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:135812
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:148217
Biological Process	GO:0032922	circadian regulation of gene expression	IBA	J:265628
Biological Process	GO:0007623	circadian rhythm	IEP	J:207820
Biological Process	GO:0007623	circadian rhythm	IMP	J:18005
Biological Process	GO:0007623	circadian rhythm	IMP	J:76640
Biological Process	GO:0007623	circadian rhythm	IDA	J:84699
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:209461
Biological Process	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	IDA	J:209461
Biological Process	GO:0042753	positive regulation of circadian rhythm	IMP	J:188853
Biological Process	GO:0042753	positive regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:154880
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:79730
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:245363
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:209571
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:206921
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:188853
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:147991
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:176743
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:165365
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:135812
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:213082
Biological Process	GO:0050729	positive regulation of inflammatory response	IMP	J:211236
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:189804
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:178280
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:87263
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:186072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:146624
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:109095
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	J:198047
Biological Process	GO:0006473	protein acetylation	IDA	J:250437
Biological Process	GO:0006473	protein acetylation	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:271702
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:188853
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:76640
Biological Process	GO:0042634	regulation of hair cycle	ISO	J:164563
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:162641
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:2000074	regulation of type B pancreatic cell development	IMP	J:162641
Biological Process	GO:0051775	response to redox state	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007283	spermatogenesis	IMP	J:189932