GO Annotations Graph

• Symbol: Irf8
• Name: interferon regulatory factor 8
• ID: MGI:96395

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:131331
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:81126
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:188767
Molecular Function	GO:0005515	protein binding	IPI	J:131331
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:190341
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:218799
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:218799
Cellular Component	GO:0005634	nucleus	IDA	J:131331
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:111178
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IMP	J:131331
Biological Process	GO:0042832	defense response to protozoan	IMP	J:111178
Biological Process	GO:0097028	dendritic cell differentiation	IMP	J:111485
Biological Process	GO:0002316	follicular B cell differentiation	IGI	J:275800
Biological Process	GO:0002314	germinal center B cell differentiation	IGI	J:275800
Biological Process	GO:0006955	immune response	IMP	J:111485
Biological Process	GO:0006955	immune response	IMP	J:81126
Biological Process	GO:0002376	immune system process	IBA	J:265628
Biological Process	GO:0032615	interleukin-12 production	IMP	J:111178
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:81126
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:218799
Biological Process	GO:0006909	phagocytosis	IMP	J:131331
Biological Process	GO:0002273	plasmacytoid dendritic cell differentiation	IMP	J:110873
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IPI	J:131331
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:111178
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:275800
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:111178
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:81126
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032479	regulation of type I interferon production	IMP	J:111485
Biological Process	GO:0009617	response to bacterium	IMP	J:111178
Biological Process	GO:0032609	type II interferon production	IMP	J:111178