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GO Annotations Graph
Symbol
Name
ID
Nod2
nucleotide-binding oligomerization domain containing 2
MGI:2429397

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0003779actin bindingISOJ:164563
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0050700CARD domain bindingISOJ:164563
Molecular FunctionGO:0016888endodeoxyribonuclease activity, producing 5'-phosphomonoestersIEAJ:72247
Molecular FunctionGO:0019899enzyme bindingISOJ:164563
Molecular FunctionGO:0030544Hsp70 protein bindingISOJ:164563
Molecular FunctionGO:0051879Hsp90 protein bindingISOJ:164563
Molecular FunctionGO:0032500muramyl dipeptide bindingISOJ:155856
Molecular FunctionGO:0032500muramyl dipeptide bindingISOJ:164563
Molecular FunctionGO:0032500muramyl dipeptide bindingIDAJ:132395
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0042834peptidoglycan bindingTASJ:114723
Molecular FunctionGO:0042834peptidoglycan bindingISOJ:164563
Molecular FunctionGO:0005515protein bindingIPIJ:161279
Molecular FunctionGO:0005515protein bindingIPIJ:117799
Molecular FunctionGO:0005515protein bindingIPIJ:169881
Molecular FunctionGO:0019901protein kinase bindingISOJ:164563
Cellular ComponentGO:0016323basolateral plasma membraneISOJ:164563
Cellular ComponentGO:0009986cell surfaceISOJ:164563
Cellular ComponentGO:0008180colocalizes_with
COP9 signalosome
ISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmTASJ:114723
Cellular ComponentGO:0005856cytoskeletonISOJ:164563
Cellular ComponentGO:0005829cytosolISOJ:164563
Cellular ComponentGO:0016020membraneIEAJ:60000
Cellular ComponentGO:0005886plasma membraneISOJ:164563
Cellular ComponentGO:0043234protein complexISOJ:164563
Cellular ComponentGO:0031982vesicleISOJ:164563
Biological ProcessGO:0002253activation of immune responseIMPJ:96035
Biological ProcessGO:0035419activation of MAPK activity involved in innate immune responseIDAJ:170396
Biological ProcessGO:0071225cellular response to muramyl dipeptideISOJ:164563
Biological ProcessGO:0071224cellular response to peptidoglycanIMPJ:113450
Biological ProcessGO:0002367cytokine production involved in immune responseISOJ:164563
Biological ProcessGO:0002374cytokine secretion involved in immune responseISOJ:164563
Biological ProcessGO:0006952defense responseTASJ:114723
Biological ProcessGO:0042742defense response to bacteriumISOJ:164563
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:96035
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIGIJ:132126
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:132126
Biological ProcessGO:0050830defense response to Gram-positive bacteriumIMPJ:147177
Biological ProcessGO:0016045detection of bacteriumISOJ:164563
Biological ProcessGO:0009595detection of biotic stimulusTASJ:114723
Biological ProcessGO:0032498detection of muramyl dipeptideISOJ:73065
Biological ProcessGO:0002376immune system processIEAJ:60000
Biological ProcessGO:0002381immunoglobulin production involved in immunoglobulin mediated immune responseIMPJ:96035
Biological ProcessGO:0006954inflammatory responseTASJ:114723
Biological ProcessGO:0045087innate immune responseISOJ:164563
Biological ProcessGO:0002227innate immune response in mucosaIMPJ:96035
Biological ProcessGO:0035556intracellular signal transductionISOJ:164563
Biological ProcessGO:0071608macrophage inflammatory protein-1 alpha productionIMPJ:147177
Biological ProcessGO:0030277maintenance of gastrointestinal epitheliumISOJ:164563
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIMPJ:147177
Biological ProcessGO:0002862negative regulation of inflammatory response to antigenic stimulusIMPJ:113450
Biological ProcessGO:0032689negative regulation of interferon-gamma productionIMPJ:147177
Biological ProcessGO:0032689negative regulation of interferon-gamma productionIMPJ:91804
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIDAJ:91804
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIMPJ:113450
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIMPJ:91804
Biological ProcessGO:0032701negative regulation of interleukin-18 productionIMPJ:91804
Biological ProcessGO:0032703negative regulation of interleukin-2 productionIMPJ:147177
Biological ProcessGO:2000110negative regulation of macrophage apoptotic processIDAJ:170396
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityIMPJ:91804
Biological ProcessGO:0002710negative regulation of T cell mediated immunityIMPJ:113450
Biological ProcessGO:0034136negative regulation of toll-like receptor 2 signaling pathwayIMPJ:91804
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionIMPJ:147177
Biological ProcessGO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathwayIMPJ:208236
Biological ProcessGO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathwayISOJ:73065
Biological ProcessGO:0006963positive regulation of antibacterial peptide biosynthetic processIDAJ:132395
Biological ProcessGO:0050871positive regulation of B cell activationISOJ:164563
Biological ProcessGO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriaIMPJ:96035
Biological ProcessGO:0008284positive regulation of cell proliferationISOJ:155856
Biological ProcessGO:1900017positive regulation of cytokine production involved in inflammatory responseISOJ:164563
Biological ProcessGO:0002606positive regulation of dendritic cell antigen processing and presentationIMPJ:159410
Biological ProcessGO:0002732positive regulation of dendritic cell cytokine productionISOJ:155856
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationIMPJ:169873
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIDAJ:170396
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIDAJ:132126
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeIMPJ:178691
Biological ProcessGO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIMPJ:96035
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingISOJ:73065
Biological ProcessGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDAJ:132126
Biological ProcessGO:0045089positive regulation of innate immune responseIMPJ:96035
Biological ProcessGO:0032731positive regulation of interleukin-1 beta productionISOJ:164563
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionISOJ:164563
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionIDAJ:169881
Biological ProcessGO:0032733positive regulation of interleukin-10 productionIMPJ:170396
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIMPJ:86264
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIMPJ:91804
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIMPJ:96035
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIDAJ:91804
Biological ProcessGO:0032740positive regulation of interleukin-17 productionISOJ:164563
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIDAJ:132126
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIMPJ:132126
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIMPJ:96035
Biological ProcessGO:0032755positive regulation of interleukin-6 productionIGIJ:132126
Biological ProcessGO:0032755positive regulation of interleukin-6 productionISOJ:164563
Biological ProcessGO:0032757positive regulation of interleukin-8 productionISOJ:164563
Biological ProcessGO:0046330positive regulation of JNK cascadeIDAJ:132126
Biological ProcessGO:0046330positive regulation of JNK cascadeISOJ:117799
Biological ProcessGO:0043410positive regulation of MAPK cascadeIMPJ:96035
Biological ProcessGO:0071639positive regulation of monocyte chemotactic protein-1 productionIMPJ:221560
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityISOJ:73065
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIMPJ:91804
Biological ProcessGO:1901224positive regulation of NIK/NF-kappaB signalingIMPJ:178691
Biological ProcessGO:1901224positive regulation of NIK/NF-kappaB signalingISOJ:164563
Biological ProcessGO:0051770positive regulation of nitric-oxide synthase biosynthetic processIMPJ:170396
Biological ProcessGO:0045747positive regulation of Notch signaling pathwayIDAJ:170396
Biological ProcessGO:0051353positive regulation of oxidoreductase activityIDAJ:170396
Biological ProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationIMPJ:96035
Biological ProcessGO:0050766positive regulation of phagocytosisIMPJ:147177
Biological ProcessGO:0043552positive regulation of phosphatidylinositol 3-kinase activityIMPJ:170396
Biological ProcessGO:2000363positive regulation of prostaglandin-E synthase activityIDAJ:170396
Biological ProcessGO:0060585positive regulation of prostaglandin-endoperoxide synthase activityIDAJ:170396
Biological ProcessGO:0031398positive regulation of protein ubiquitinationIDAJ:159062
Biological ProcessGO:0032874positive regulation of stress-activated MAPK cascadeISOJ:117799
Biological ProcessGO:0032874positive regulation of stress-activated MAPK cascadeIDAJ:132126
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterISOJ:164563
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:91804
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIGIJ:132126
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionISOJ:164563
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIMPJ:132126
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionIDAJ:132126
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionISOJ:117799
Biological ProcessGO:0002830positive regulation of type 2 immune responseISOJ:164563
Biological ProcessGO:1904417positive regulation of xenophagyIMPJ:178691
Biological ProcessGO:0051259protein oligomerizationTASJ:114723
Biological ProcessGO:0042981regulation of apoptotic processIEAJ:72247
Biological ProcessGO:0050727regulation of inflammatory responseIMPJ:178054
Biological ProcessGO:0090022regulation of neutrophil chemotaxisIMPJ:147177
Biological ProcessGO:0043330response to exogenous dsRNAIMPJ:96035
Biological ProcessGO:0032496response to lipopolysaccharideIMPJ:86264
Biological ProcessGO:0032496response to lipopolysaccharideIMPJ:96035
Biological ProcessGO:0032495response to muramyl dipeptideISOJ:155856
Biological ProcessGO:0032495response to muramyl dipeptideIMPJ:91804
Biological ProcessGO:0032495response to muramyl dipeptideIMPJ:96035
Biological ProcessGO:0032495response to muramyl dipeptideIMPJ:86264
Biological ProcessGO:0032495response to muramyl dipeptideIDAJ:91804
Biological ProcessGO:0032495response to muramyl dipeptideISOJ:164563
Biological ProcessGO:0032495response to muramyl dipeptideIDAJ:169881
Biological ProcessGO:0032494response to peptidoglycanIMPJ:91804
Biological ProcessGO:0032494response to peptidoglycanIDAJ:91804
Biological ProcessGO:0007165signal transductionTASJ:114723


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory