GO Annotations Graph

• Symbol: E2f8
• Name: E2F transcription factor 8
• ID: MGI:1922038

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:99083
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:190713
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:190714
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:183999
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IMP	J:183999
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IMP	J:190714
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IMP	J:190713
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:99083
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:99083
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IEA	J:72247
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0033301	cell cycle comprising mitosis without cytokinesis	IMP	J:190713
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	IMP	J:183999
Biological Process	GO:0048144	fibroblast proliferation	IDA	J:99083
Biological Process	GO:0070365	hepatocyte differentiation	IMP	J:190713
Biological Process	GO:0070365	hepatocyte differentiation	IMP	J:190714
Biological Process	GO:0032466	negative regulation of cytokinesis	IMP	J:190713
Biological Process	GO:0032466	negative regulation of cytokinesis	IMP	J:190714
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:190713
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:183999
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:190714
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0001890	placenta development	IMP	J:183999
Biological Process	GO:0032877	positive regulation of DNA endoreduplication	IMP	J:190713
Biological Process	GO:0032877	positive regulation of DNA endoreduplication	IMP	J:190714
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:189923
Biological Process	GO:0002040	sprouting angiogenesis	ISO	J:164563
Biological Process	GO:0060707	trophoblast giant cell differentiation	IMP	J:190713