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GO Annotations Graph
Symbol
Name
ID
Mre11a
MRE11A homolog A, double strand break repair nuclease
MGI:1100512

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:00084083'-5' exonuclease activityISOJ:164563
Molecular FunctionGO:0004003contributes_to
ATP-dependent DNA helicase activity
ISOJ:164563
Molecular FunctionGO:0003677contributes_to
DNA binding
ISOJ:164563
Molecular FunctionGO:0004520endodeoxyribonuclease activityISOJ:164563
Molecular FunctionGO:0004519endonuclease activityIEAJ:60000
Molecular FunctionGO:0004519endonuclease activityIEAJ:72247
Molecular FunctionGO:0004527exonuclease activityIEAJ:60000
Molecular FunctionGO:0016787hydrolase activityIEAJ:60000
Molecular FunctionGO:0016787hydrolase activityIEAJ:72247
Molecular FunctionGO:0030145manganese ion bindingIEAJ:72247
Molecular FunctionGO:0004518nuclease activityIEAJ:60000
Molecular FunctionGO:0008022protein C-terminus bindingISOJ:164563
Molecular FunctionGO:0000014single-stranded DNA endodeoxyribonuclease activityISOJ:164563
Cellular ComponentGO:0000781colocalizes_with
chromosome, telomeric region
ISOJ:164563
Cellular ComponentGO:0000794condensed nuclear chromosomeISOJ:155856
Cellular ComponentGO:0030870Mre11 complexISOJ:73065
Cellular ComponentGO:0000790nuclear chromatinISOJ:155856
Cellular ComponentGO:0000784colocalizes_with
nuclear chromosome, telomeric region
ISOJ:164563
Cellular ComponentGO:0000784colocalizes_with
nuclear chromosome, telomeric region
IDAJ:228107
Cellular ComponentGO:0000784nuclear chromosome, telomeric regionISOJ:164563
Cellular ComponentGO:0005654nucleoplasmISOJ:155856
Cellular ComponentGO:0005654nucleoplasmISOJ:164563
Cellular ComponentGO:0005634nucleusIDAJ:84394
Cellular ComponentGO:0005634nucleusISOJ:155856
Cellular ComponentGO:0005634nucleusIDAJ:92518
Cellular ComponentGO:0048471perinuclear region of cytoplasmISOJ:155856
Cellular ComponentGO:0016605PML bodyIDAJ:228107
Cellular ComponentGO:0016605PML bodyISOJ:164563
Cellular ComponentGO:0035861site of double-strand breakISOJ:164563
Biological ProcessGO:0008283cell proliferationIMPJ:42675
Biological ProcessGO:0006974cellular response to DNA damage stimulusISOJ:123598
Biological ProcessGO:0051276chromosome organizationIMPJ:87088
Biological ProcessGO:0032508DNA duplex unwindingISOJ:164563
Biological ProcessGO:0006281DNA repairIEAJ:60000
Biological ProcessGO:0006302double-strand break repairIMPJ:120745
Biological ProcessGO:0006303double-strand break repair via nonhomologous end joiningISOJ:164563
Biological ProcessGO:0031573intra-S DNA damage checkpointIMPJ:87088
Biological ProcessGO:0031573intra-S DNA damage checkpointIMPJ:138550
Biological ProcessGO:0051321meiotic cell cycleIEAJ:60000
Biological ProcessGO:0007095mitotic G2 DNA damage checkpointIMPJ:87088
Biological ProcessGO:0043066negative regulation of apoptotic processISOJ:164563
Biological ProcessGO:0032876negative regulation of DNA endoreduplicationISOJ:164563
Biological ProcessGO:0046597negative regulation of viral entry into host cellISOJ:155856
Biological ProcessGO:0090305nucleic acid phosphodiester bond hydrolysisISOJ:164563
Biological ProcessGO:0033674positive regulation of kinase activityISOJ:164563
Biological ProcessGO:0031954positive regulation of protein autophosphorylationISOJ:164563
Biological ProcessGO:0032206positive regulation of telomere maintenanceISOJ:164563
Biological ProcessGO:0007062sister chromatid cohesionISOJ:164563
Biological ProcessGO:0007129synapsisIMPJ:120745
Biological ProcessGO:0031860telomeric 3' overhang formationISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory