GO Annotations Graph

• Symbol: Mre11a
• Name: MRE11A homolog A, double strand break repair nuclease
• ID: MGI:1100512

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISO	J:164563
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	IEA	J:72247
Molecular Function	GO:0008409	5'-3' exonuclease activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004520	DNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0003678	DNA helicase activity	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0004519	endonuclease activity	IEA	J:72247
Molecular Function	GO:0004527	exonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0030145	manganese ion binding	IEA	J:72247
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:265834
Molecular Function	GO:0005515	protein binding	IPI	J:129762
Molecular Function	GO:0005515	protein binding	IPI	J:147247
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	ISO	J:164563
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	IBA	J:265628
Cellular Component	GO:0070533	BRCA1-C complex	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0098687	chromosomal region	NAS	J:320151
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:228107
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030870	Mre11 complex	IBA	J:265628
Cellular Component	GO:0030870	Mre11 complex	ISO	J:73065
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:155856
Cellular Component	GO:0005634	nucleus	NAS	J:319979
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:92518
Cellular Component	GO:0005634	nucleus	IDA	J:84394
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0016605	PML body	ISO	J:164563
Cellular Component	GO:0016605	PML body	IDA	J:228107
Cellular Component	GO:0005657	replication fork	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0008283	cell population proliferation	IMP	J:42675
Biological Process	GO:0051276	chromosome organization	IMP	J:87088
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:123598
Biological Process	GO:0000729	DNA double-strand break processing	NAS	J:320151
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	NAS	J:320083
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IMP	J:120745
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IBA	J:265628
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:120745
Biological Process	GO:0035825	homologous recombination	NAS	J:319683
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0042138	meiotic DNA double-strand break formation	IBA	J:265628
Biological Process	GO:0097552	mitochondrial double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IMP	J:87088
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	NAS	J:320080
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	IMP	J:87088
Biological Process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	IMP	J:138550
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0046597	negative regulation of viral entry into host cell	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	ISO	J:164563
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0007062	sister chromatid cohesion	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0031860	telomeric 3' overhang formation	ISO	J:164563