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Hipk3 Gene Detail
Summary
  • Symbol
    Hipk3
  • Name
    homeodomain interacting protein kinase 3
  • Synonyms
    DYRK6, FIST3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314882
    NCBI Gene: 15259
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:104256826-104324791 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.74 cM
Strain
Comparison
more
  • SNPs within 2kb
    1248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314882
protein coding gene Chr2:104256826-104324834 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026217
protein coding gene Chr2:106528687-106608009 (-)
A/J MGP_AJ_G0026178
protein coding gene Chr2:102084066-102153494 (-)
AKR/J MGP_AKRJ_G0026157
protein coding gene Chr2:104856506-104930908 (-)
BALB/cJ MGP_BALBcJ_G0026187
protein coding gene Chr2:102368614-102436915 (-)
C3H/HeJ MGP_C3HHeJ_G0025938
protein coding gene Chr2:105182552-105253307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026638
protein coding gene Chr2:110032265-110107331 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024025
protein coding gene Chr2:97895691-97963091 (-)
CAST/EiJ MGP_CASTEiJ_G0025402
protein coding gene Chr2:105668950-105752244 (-)
CBA/J MGP_CBAJ_G0025915
protein coding gene Chr2:113796831-113876165 (-)
DBA/2J MGP_DBA2J_G0026053
protein coding gene Chr2:101636029-101706219 (-)
FVB/NJ MGP_FVBNJ_G0026015
protein coding gene Chr2:100618155-100689403 (-)
LP/J MGP_LPJ_G0026156
protein coding gene Chr2:106630728-106704370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026040
protein coding gene Chr2:117688966-117760680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026692
protein coding gene Chr2:105061872-105135190 (-)
PWK/PhJ MGP_PWKPhJ_G0025137
protein coding gene Chr2:101162568-101233256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024937
protein coding gene Chr2:104284202-104360696 (-)
WSB/EiJ MGP_WSBEiJ_G0025469
protein coding gene Chr2:105794214-105865687 (-)



Homology
more
  • Human Ortholog
    HIPK3, homeodomain interacting protein kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIPK3, homeodomain interacting protein kinase 3
  • Synonyms
    DYRK6, FIST3, PKY, YAK1
  • Links
    NCBI Gene ID: 10114
    neXtProt AC: NX_Q9H422
    UniProt: Q9H422

  • Chr Location
    11p13; chr11:33256672-33357023 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit impaired insulin secretion and glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027177 Ensembl Gene Model | MGI Sequence Detail 67966 C57BL/6J ±  kb
    transcript ENSMUST00000111125 Ensembl | MGI Sequence Detail 3651 Not Applicable  
    polypeptide ENSMUSP00000106754 Ensembl | MGI Sequence Detail 1213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 110
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.
    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory