Tgfbi
Gene Detail

Symbol Name ID

Tgfbi transforming growth factor, beta induced MGI:99959

Synonyms

68kDa, Beta-ig, bIG-h3

Feature Type

protein coding gene

Genetic Map

Chromosome 13

30.09 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr13:56609603-56639339 bp, + strand From NCBI annotation of GRCm38   29737 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Tgfbi

Human homologs

Human Homolog		TGFBI, transforming growth factor, beta-induced, 68kDa
NCBI Gene ID		7045
neXtProt AC		NX_Q15582
Human Synonyms		BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Human Chr (Location)		5q31; chr5:135364584-135399507 (+)  GRCh37.p10
Disease Associations		(7) Diseases Associated with Human TGFBI

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit postnatal growth retardation with increased incidence of tumors and chemically-induced tumors.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cell adhesion, extracellular matrix organization
Component	basement membrane, extracellular matrix, ...
Function	extracellular matrix binding

External Resources: FuncBase

Expression

Literature Summary: (23 records)
Data Summary: Results (618)    Tissues (295)    Images (72)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	618

cDNA source data(141)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(142) cDNA(142)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000035493 (Evidence)
Entrez Gene	21810 (Evidence)
UniGene	14455
DFCI	TC1573454
DoTS	DT.101356297, DT.494733, DT.94203123, DT.97333790
Consensus CDS Project	CCDS36680.1
International Mouse Knockout Project Status	Tgfbi

Sequences

Length	Strain/Species
genomic	21810	NCBI Gene Model | MGI Sequence Detail	29737	C57BL/6J
transcript	NM_009369	RefSeq | MGI Sequence Detail	2678	C57BL/6
polypeptide	P82198	UniProt | EBI | MGI Sequence Detail	683	Not Applicable

All sequences(44) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(231 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011489	EMI domain
InterPro	IPR000782	FAS1 domain
InterPro	IPR016666	TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology	PR:000016287	transforming growth factor-beta-induced protein ig-h3

Graphical View of Protein Domain Structure

References

(Earliest) J:19105 Skonier J, et al., beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 1994 Jun;13(6):571-84
(Latest) J:187969 Pazin DE, et al., Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
All references(55)

Other accession IDs

MGD-MRK-16764, MGI:2145190, MGI:2145285