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Tgfbi
Gene Detail
 Symbol
Name
ID
Tgfbi
transforming growth factor, beta induced
MGI:99959
Synonyms 68kDa, Beta-ig, bIG-h3
Feature Type protein coding gene
Genetic Map
Chromosome 13
30.09 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:56609603-56639339 bp, + strand
From NCBI annotation of GRCm38

  29737 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Tgfbi

Human
homologs
Human Homolog TGFBI, transforming growth factor, beta-induced, 68kDa
NCBI Gene ID 7045
neXtProt AC  NX_Q15582
Human Synonyms  BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Human Chr (Location)  5q31; chr5:136028895-136063818 (+)  GRCh38
Disease Associations  (7) Diseases Associated with Human TGFBI
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal growth retardation with increased incidence of tumors and chemically-induced tumors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, extracellular matrix organization
Component basement membrane, extracellular matrix, ...
Function collagen binding, extracellular matrix binding
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (618)    Tissues (295)    Images (72)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 618
cDNA source data(142)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(143) cDNA(143)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000035493 (Evidence)
Entrez Gene21810 (Evidence)
UniGene14455
DFCITC1573454
DoTSDT.101356297, DT.494733, DT.94203123, DT.97333790
Consensus CDS ProjectCCDS36680.1
International Mouse Knockout Project StatusTgfbi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21810 NCBI Gene Model | MGI Sequence Detail 29737 C57BL/6J ±  kb
transcript NM_009369 RefSeq | MGI Sequence Detail 2678 C57BL/6 
polypeptide P82198 UniProt | EBI | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011489 EMI domain
InterPro IPR000782 FAS1 domain
InterPro IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology PR:000016287 transforming growth factor-beta-induced protein ig-h3
Graphical View of Protein Domain Structure
References (Earliest) J:19105 Skonier J, et al., beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 1994 Jun;13(6):571-84
(Latest) J:199282 Gunschmann C, et al., Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Dev Cell. 2013 Jul 29;26(2):176-87
All references(56)
Other
accession IDs
MGD-MRK-16764, MGI:2145190, MGI:2145285

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory