About   Help   FAQ
Tgfbi
Gene Detail
Symbol

Name
ID
Tgfbi
transforming growth factor, beta induced
MGI:99959
Synonyms
68kDa, Beta-ig, bIG-h3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.09 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:56609603-56639339 bp, + strand
From NCBI annotation of GRCm38

  29737 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGFBI
Protein SuperFamily: TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Gene Tree: Tgfbi

Human
homologs
TGFBI, transforming growth factor, beta-induced, 68kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7045
neXtProt AC: NX_Q15582

Human Synonyms: BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1

Human Chr (Location): 5q31; chr5:136028895-136063818 (+)  GRCh38.p2

Disease Associations: (7) Diseases Associated with Human TGFBI

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit postnatal growth retardation with increased incidence of tumors and chemically-induced tumors.
 
Interactions
Tgfbi interacts with 115 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion, extracellular matrix organization
Component basement membrane, extracellular exosome, ...
Function cell adhesion molecule binding, collagen binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (656)    Tissues (331)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 650
Northern blot 6
cDNA source data(142)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tgfbi ; ZFIN tgfbi    NEW 
Molecular
reagents
All nucleic(145) cDNA(144) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000035493 (Evidence)
Entrez Gene 21810 (Evidence)
UniGene 14455
DFCI TC1573454
DoTS DT.101356297, DT.494733, DT.94203123, DT.97333790
Consensus CDS Project CCDS36680.1
International Mouse Phenotyping Consortium Status Tgfbi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21810 NCBI Gene Model | MGI Sequence Detail 29737 C57BL/6J ±  kb
transcript NM_009369 RefSeq | MGI Sequence Detail 2678 C57BL/6 
polypeptide P82198 UniProt | EBI | MGI Sequence Detail 683 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(249 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011489 EMI domain
InterPro IPR000782 FAS1 domain
InterPro IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
Protein Ontology PR:000016287 transforming growth factor-beta-induced protein ig-h3
Graphical View of Protein Domain Structure
References
(Earliest) J:19105 Skonier J, et al., beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 1994 Jun;13(6):571-84
(Latest) J:214677 Bohnenpoll T, et al., Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. Dev Biol. 2014 Jul 1;391(1):54-65
All references(58)
Other
accession IDs
MGD-MRK-16764, MGI:2145190, MGI:2145285

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory