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Zfhx3 Gene Detail
Summary
  • Symbol
    Zfhx3
  • Name
    zinc finger homeobox 3
  • Synonyms
    A230102L03Rik, Atbf1, WBP9
  • Feature Type
    protein coding gene
  • IDs
    MGI:99948
    NCBI Gene: 11906
  • Alliance
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:109005975-109688268 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 56.02 cM, cytoband E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2909 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99948
protein coding gene Chr8:108669276-109688268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034104
protein coding gene Chr8:111243585-111515902 (+)
A/J MGP_AJ_G0034084
protein coding gene Chr8:106740948-107001968 (+)
AKR/J MGP_AKRJ_G0034010
protein coding gene Chr8:109880692-110149447 (+)
BALB/cJ MGP_BALBcJ_G0034077
protein coding gene Chr8:106949066-107213347 (+)
C3H/HeJ MGP_C3HHeJ_G0033789
protein coding gene Chr8:110589794-110860378 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034597
protein coding gene Chr8:115200844-115468773 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031539
protein coding gene Chr8:99805228-100056391 (+)
CAST/EiJ MGP_CASTEiJ_G0033116
protein coding gene Chr8:110169212-110442564 (+)
CBA/J MGP_CBAJ_G0033762
protein coding gene Chr8:119026925-119313708 (+)
DBA/2J MGP_DBA2J_G0033917
protein coding gene Chr8:106078166-106338713 (+)
FVB/NJ MGP_FVBNJ_G0033862
protein coding gene Chr8:105015270-105278897 (+)
LP/J MGP_LPJ_G0034008
protein coding gene Chr8:111421451-111695610 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033907
protein coding gene Chr8:122110688-122382336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034616
protein coding gene Chr8:109827254-110096916 (+)
PWK/PhJ MGP_PWKPhJ_G0032818
protein coding gene Chr8:105508437-105777084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032657
protein coding gene Chr8:108548431-108817713 (+)
WSB/EiJ MGP_WSBEiJ_G0033231
protein coding gene Chr8:110505044-110779434 (+)



Homology
more
  • Human Ortholog
    ZFHX3, zinc finger homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFHX3, zinc finger homeobox 3
  • Synonyms
    ATBF1, ATBT, ATFB8, C16orf47, SCA4, ZFH-3, ZNF927
  • Links
    NCBI Gene ID: 463
    neXtProt AC: NX_Q15911
    UniProt: Q15911

  • Chr Location
    16q22.2-q22.3; chr16:72782885-73891930 (-)  GRCh38

Human Diseases
more
  • Diseases
    6 with human ZFHX3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11906 NCBI Gene Model | MGI Sequence Detail 682294 C57BL/6J ±  kb
    transcript NM_007496 RefSeq | MGI Sequence Detail 16098 C57BL/6  
    polypeptide Q61329 UniProt | EBI | MGI Sequence Detail 3726 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 3
      cDNA 23
      Primer pair 5
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16751, MGI:1915410, MGI:2679553
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 41
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
    • Latest
      J:340810 Nishida K, et al., Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons. PLoS One. 2023;18(9):e0285295

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory