Zfhx3
Gene Detail

Symbol Name ID

Zfhx3 zinc finger homeobox 3 MGI:99948

Synonyms

A230102L03Rik, Atbf1, WBP9

Feature Type

protein coding gene

Genetic Map

Chromosome 8

56.02 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:108714644-108961636 bp, + strand From VEGA annotation of GRCm38   246993 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfhx3

Human homologs

Human Homolog		ZFHX3, zinc finger homeobox 3
NCBI Gene ID		463
neXtProt AC		NX_Q15911
Human Synonyms		ATBF1, ATBT, ZNF927
Human Chr (Location)		16q22.3; chr16:72782885-73058635 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ZFHX3

Alleles and phenotypes

All alleles(36) : Targeted(3) Gene trapped(33)
 

Mice homozygous for a gene trapped allele exhibit normal pituitary development. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	muscle organ development, negative regulation of myoblast differentiation, ...
Component	cytoplasm, mitochondrion, ...
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)

Data Summary: Results (359)    Tissues (139)    Images (44)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	295
Northern blot	8
RT-PCR	56

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(2) cDNA(22) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000041077 (Evidence)
Ensembl Gene Model	ENSMUSG00000038872 (Evidence)
Entrez Gene	11906 (Evidence)
DFCI	TC1584385, TC1745606
DoTS	DT.525210
NIA Mouse Gene Index	U009800
Consensus CDS Project	CCDS22651.1
International Mouse Knockout Project Status	Zfhx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000041077	VEGA Gene Model | MGI Sequence Detail	246993	C57BL/6J
transcript	OTTMUST00000107189	VEGA | MGI Sequence Detail	16439	Not Applicable
polypeptide	OTTMUSP00000059856	VEGA | MGI Sequence Detail	3723	Not Applicable

All sequences(38) RefSeq(6) UniProt(6)

Polymorphisms

SNPs within 2kb(1195 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
InterPro	IPR003604	Zinc finger, U1-type
Protein Ontology	PR:000017628	zinc finger homeobox protein 3

References

(Earliest) J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
(Latest) J:195826 Komine Y, et al., Behavioral abnormalities observed in Zfhx2-deficient mice. PLoS One. 2012;7(12):e53114
All references(60)

Other accession IDs

MGD-MRK-16751, MGI:1915410