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Zfhx3 Gene Detail
Summary
  • Symbol
    Zfhx3
  • Name
    zinc finger homeobox 3
  • Synonyms
    A230102L03Rik, Atbf1, WBP9
  • Feature Type
    protein coding gene
  • IDs
    MGI:99948
    NCBI Gene: 11906
  • Gene Overview
    MyGene.info: ZFHX3
Location & Maps
more
  • Sequence Map
    Chr8:108703100-108961630 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      258531 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 56.02 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ZFHX3, zinc finger homeobox 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFHX3, zinc finger homeobox 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATBF1, ATBT, ZNF927
  • Links
    NCBI Gene ID: 463
    neXtProt AC: NX_Q15911
    UniProt: Q15911

  • Chr Location
    16q22.2-q22.3; chr16:72782885-73058635 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 21366
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZFHX3
  • Gene Tree
    Zfhx3
Human Diseases
more
  • Diseases
    1 with human ZFHX3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    352
  • Tissues
    146
  • cDNA Data
    21
  • Literature Summary
    23
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041077 VEGA Gene Model | MGI Sequence Detail 258531 C57BL/6J ±  kb
transcript OTTMUST00000107189 VEGA | MGI Sequence Detail 16433 Not Applicable  
polypeptide OTTMUSP00000059856 VEGA | MGI Sequence Detail 3723 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1176 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    Genomic 2
    cDNA 22
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-16751, MGI:1915410, MGI:2679553
References
more
  • Summaries
    All 62
    Developmental Gene Expression 23
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
  • Latest
    J:238583 Balzani E, et al., The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice. Cell Rep. 2016 Jul 19;16(3):615-21
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory