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Zfhx3
Gene Detail
Symbol

Name
ID
Zfhx3
zinc finger homeobox 3
MGI:99948
Synonyms
A230102L03Rik, Atbf1, WBP9
Feature Type
protein coding gene
Genetic Map
Chromosome 8
56.02 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:108703100-108961630 bp, + strand
From VEGA annotation of GRCm38

  258531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfhx3

Human
homologs
Human Homolog ZFHX3, zinc finger homeobox 3
NCBI Gene ID 463
neXtProt AC  NX_Q15911
Human Synonyms  ATBF1, ATBT, ZNF927
Human Chr (Location)  16q22.3; chr16:72782885-73058635 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZFHX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(36) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit normal pituitary development. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.
 
Phenotype Images(1)
Interactions
Zfhx3 interacts with 501 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process muscle organ development, negative regulation of myoblast differentiation, ...
Component cytoplasm, mitochondrion, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (352)    Tissues (146)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 295
Northern blot 8
RT-PCR 49
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(22) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000041077 (Evidence)
Ensembl Gene ModelENSMUSG00000038872 (Evidence)
Entrez Gene11906 (Evidence)
DFCITC1584385, TC1745606
DoTSDT.525210
NIA Mouse Gene IndexU009800
Consensus CDS ProjectCCDS22651.1
International Mouse Knockout Project StatusZfhx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041077 VEGA Gene Model | MGI Sequence Detail 258531 C57BL/6J ±  kb
transcript OTTMUST00000107189 VEGA | MGI Sequence Detail 16433 Not Applicable 
polypeptide OTTMUSP00000059856 VEGA | MGI Sequence Detail 3723 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(12)
Polymorphisms
SNPs within 2kb(1198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
InterPro IPR003604 Zinc finger, U1-type
Protein Ontology PR:000017628 zinc finger homeobox protein 3
References
(Earliest) J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
(Latest) J:195826 Komine Y, et al., Behavioral abnormalities observed in Zfhx2-deficient mice. PLoS One. 2012;7(12):e53114
All references(60)
Other
accession IDs
MGD-MRK-16751, MGI:1915410

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory