Zfhx3
Gene Detail

Symbol

Name
ID

Zfhx3
zinc finger homeobox 3
MGI:99948

Synonyms

A230102L03Rik, Atbf1, WBP9

Feature Type

protein coding gene

Genetic Map

Chromosome 8
56.02 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:108703100-108961630 bp, + strand From VEGA annotation of GRCm38   258531 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:21366  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfhx3

Human
homologs

Human Homolog		ZFHX3, zinc finger homeobox 3
NCBI Gene ID		463
neXtProt AC		NX_Q15911
Human Synonyms		ATBF1, ATBT, ZNF927
Human Chr (Location)		16q22.3; chr16:72782885-73058635 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human ZFHX3

Mutations,
alleles, and
phenotypes

All mutations/alleles(39) : Gene trapped(36) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a gene trapped allele exhibit normal pituitary development. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.

 
Phenotype Images(1)

Interactions

Zfhx3 interacts with 501 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	muscle organ development, negative regulation of myoblast differentiation, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (22 records)

Data Summary: Results (352)    Tissues (146)    Images (44)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	295
Northern blot	8
RT-PCR	49

cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(27) Genomic(2) cDNA(22) Primer pair(3)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000041077 (Evidence)
Ensembl Gene Model	ENSMUSG00000038872 (Evidence)
Entrez Gene	11906 (Evidence)
DFCI	TC1584385, TC1745606
DoTS	DT.525210
NIA Mouse Gene Index	U009800
Consensus CDS Project	CCDS22651.1
International Mouse Knockout Project Status	Zfhx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000041077	VEGA Gene Model | MGI Sequence Detail	258531	C57BL/6J
transcript	OTTMUST00000107189	VEGA | MGI Sequence Detail	16433	Not Applicable
polypeptide	OTTMUSP00000059856	VEGA | MGI Sequence Detail	3723	Not Applicable

All sequences(45) RefSeq(8) UniProt(7)

Polymorphisms

SNPs within 2kb(1198 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
InterPro	IPR003604	Zinc finger, U1-type
Protein Ontology	PR:000017628	zinc finger homeobox protein 3

References

(Earliest) J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
(Latest) J:195826 Komine Y, et al., Behavioral abnormalities observed in Zfhx2-deficient mice. PLoS One. 2012;7(12):e53114
All references(60)

Other
accession IDs

MGD-MRK-16751, MGI:1915410