Zfhx3 MGI Mouse Gene Detail - MGI:99948

Symbol

Zfhx3
Name

zinc finger homeobox 3
Synonyms

A230102L03Rik, Atbf1, WBP9

Feature Type

protein coding gene
IDs

MGI:99948
NCBI Gene: 11906
Gene Overview

MyGene.info: ZFHX3
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr8:108704177-108961636 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 56.02 cM, cytoband E1
Mapping Data

4 experiments

SNPs within 2kb

1174 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99948	protein coding gene	Chr8:107942644-108961636 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034104	protein coding gene	Chr8:111243585-111515902 (+)
A/J	MGP_AJ_G0034084	protein coding gene	Chr8:106740948-107001968 (+)
AKR/J	MGP_AKRJ_G0034010	protein coding gene	Chr8:109880692-110149447 (+)
BALB/cJ	MGP_BALBcJ_G0034077	protein coding gene	Chr8:106949066-107213347 (+)
C3H/HeJ	MGP_C3HHeJ_G0033789	protein coding gene	Chr8:110589794-110860378 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034597	protein coding gene	Chr8:115200844-115468773 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031539	protein coding gene	Chr8:99805228-100056391 (+)
CAST/EiJ	MGP_CASTEiJ_G0033116	protein coding gene	Chr8:110169212-110442564 (+)
CBA/J	MGP_CBAJ_G0033762	protein coding gene	Chr8:119026925-119313708 (+)
DBA/2J	MGP_DBA2J_G0033917	protein coding gene	Chr8:106078166-106338713 (+)
FVB/NJ	MGP_FVBNJ_G0033862	protein coding gene	Chr8:105015270-105278897 (+)
LP/J	MGP_LPJ_G0034008	protein coding gene	Chr8:111421451-111695610 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033907	protein coding gene	Chr8:122110688-122382336 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034616	protein coding gene	Chr8:109827254-110096916 (+)
PWK/PhJ	MGP_PWKPhJ_G0032818	protein coding gene	Chr8:105508437-105777084 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032657	protein coding gene	Chr8:108548431-108817713 (+)
WSB/EiJ	MGP_WSBEiJ_G0033231	protein coding gene	Chr8:110505044-110779434 (+)

Human Ortholog

ZFHX3, zinc finger homeobox 3

Vertebrate Orthologs

10

Human Ortholog

ZFHX3, zinc finger homeobox 3
Orthology source: HomoloGene, HGNC
Synonyms

ATBF1, ATBT, ZNF927
Links

HGNC:777

NCBI Gene ID: 463

neXtProt AC: NX_Q15911

UniProt: Q15911
Chr Location

16q22.2-q22.3; chr16:72782885-73058635 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21366
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ZFHX3
Gene Tree

Zfhx3

Diseases

1 with human ZFHX3 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

1
Gene trapped

36
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time.

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All GO Annotations

37
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

382
Tissues

160
cDNA Data

21
Literature Summary

29

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfhx3

ZFIN zfhx3

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Zfhx3 interacts with 500 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

60
RefSeq

8
UniProt

7
CCDS

CCDS22651.1

Ensembl

ENSMUSG00000038872 (Evidence)
NCBI Gene

11906

			Length	Strain/Species	Flank
genomic	11906	NCBI Gene Model \| MGI Sequence Detail	257460	C57BL/6J	± kb
transcript	NM_007496	RefSeq \| MGI Sequence Detail	16439	Not Specified
polypeptide	Q61329	UniProt \| EBI \| MGI Sequence Detail	3726	Not Applicable

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UniProt

7 Sequences
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 31

Genomic 3

cDNA 22

Primer pair 5

Other 1

Microarray probesets 7

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MGD-MRK-16751, MGI:1915410, MGI:2679553

Summaries

All 70

Developmental Gene Expression 29

Gene Ontology 9

Phenotypes 14
Earliest

J:17985 Ido A, et al., Activation of ATBF1, a multiple-homeodomain zinc-finger gene, during neuronal differentiation of murine embryonal carcinoma cells. Dev Biol. 1994 May;163(1):184-7
Latest

J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

TSS for Zfhx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79326	Chr8:108703454-108703501 (+)	-699 bp
Tssr79327	Chr8:108703555-108703564 (+)	-617 bp
Tssr79328	Chr8:108703593-108703617 (+)	-572 bp
Tssr79336	Chr8:108714958-108715057 (+)	10,831 bp
Tssr79337	Chr8:108715058-108715098 (+)	10,901 bp
Tssr79343	Chr8:108948158-108948169 (+)	243,987 bp
Tssr79345	Chr8:108957285-108957287 (+)	253,109 bp
Tssr79346	Chr8:108957863-108957867 (+)	253,688 bp
Tssr79347	Chr8:108958871-108958890 (+)	254,704 bp
Tssr79348	Chr8:108958951-108958957 (+)	254,777 bp
Tssr79349	Chr8:108959476-108959480 (+)	255,301 bp
Tssr79350	Chr8:108959563-108959587 (+)	255,398 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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