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Jak3
Gene Detail
Symbol

Name
ID
Jak3
Janus kinase 3
MGI:99928
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:71676296-71690575 bp, + strand
From VEGA annotation of GRCm38

  14280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:181  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Jak3

Human
homologs
Human Homolog JAK3, Janus kinase 3
NCBI Gene ID 3718
neXtProt AC  NX_P52333
Human Synonyms  JAK-3, JAK3_HUMAN, JAKL, LJAK, L-JAK
Human Chr (Location)  19p13.1; chr19:17824782-17848071 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human JAK3
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(3) Gene trapped(14) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired B cell development, small thymi and T cell proliferate. Point mutation homozygotes develop autoimmune inflammatory bowel disease, decreased susceptibility to malaria infection and/or increased susceptibility to bacterial infection.
 
Human Diseases Modeled Using Mouse Jak3 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Jak3 interacts with 53 markers (Mir17, Mir20b, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process B cell differentiation, cytokine-mediated signaling pathway, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(14) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021111 (Evidence)
Ensembl Gene ModelENSMUSG00000031805 (Evidence)
Entrez Gene16453 (Evidence)
DFCITC1577507
DoTSDT.101207308, DT.101286043, DT.101363930, DT.536101, DT.91289212, DT.99845221
EC2.7.10.2
Consensus CDS ProjectCCDS22403.1
International Mouse Knockout Project StatusJak3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021111 VEGA Gene Model | MGI Sequence Detail 14280 C57BL/6J ±  kb
transcript OTTMUST00000049963 VEGA | MGI Sequence Detail 4009 Not Applicable 
polypeptide OTTMUSP00000023248 VEGA | MGI Sequence Detail 1100 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR000299 FERM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR020775 Tyrosine-protein kinase, non-receptor Jak3
InterPro IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Protein Ontology PR:000009198 tyrosine-protein kinase JAK3
References
(Earliest) J:19201 Witthuhn BA, et al., Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994 Jul 14;370(6485):153-7
(Latest) J:212843 Ambriz-Pena X, et al., Jak3 enables chemokine-dependent actin cytoskeleton reorganization by regulating cofilin and Rac/Rhoa GTPases activation. PLoS One. 2014;9(2):e88014
All references(116)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16730, MGI:3584392, MGI:3584403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory