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mt-Atp6 Gene Detail
Summary
  • Symbol
    mt-Atp6
  • Name
    mitochondrially encoded ATP synthase 6
  • Synonyms
    ATPASE6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99927
    NCBI Gene: 17705
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    ATP6, ATP synthase F0 subunit 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP6, ATP synthase F0 subunit 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATPase6, MTATP6
  • Links
    NCBI Gene ID: 4508
    neXtProt AC: NX_P00846

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    3 with human ATP6 associations

Human Disease Mouse Models
       Atp Synthase 6; MTATP6   OMIM: 516060
Leber Optic Atrophy   OMIM: 535000
Neuropathy, Ataxia, and Retinitis Pigmentosa   OMIM: 551500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    1
  • Spontaneous
    1
  • Genomic Mutations
    1 involving mt-Atp6
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064357 Ensembl Gene Model | MGI Sequence Detail 681 C57BL/6J ±  kb
transcript ENSMUST00000082408 Ensembl | MGI Sequence Detail 681 Not Applicable  
polypeptide ENSMUSP00000080996 Ensembl | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000030266 ATP synthase subunit a
  • InterPro Domains
    IPR000568 ATPase, F0 complex, subunit A
    IPR023011 ATPase, F0 complex, subunit A, active site
Molecular
Reagents
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  • All nucleic 40
    cDNA 36
    Primer pair 2
    Other 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-16729, MGI:2138390, MGI:2138397, MGI:2138428, MGI:2138431, MGI:2138433, MGI:2138437, MGI:2138438, MGI:2138440, MGI:2138444, MGI:2138445, MGI:2138449, MGI:2138458, MGI:2138460, MGI:2138461, MGI:2138463
References
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  • Summaries
    All 28
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:195548 Brody MJ, et al., Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One. 2012;7(12):e51621

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory