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mt-Atp8 Gene Detail
Summary
  • Symbol
    mt-Atp8
  • Name
    mitochondrially encoded ATP synthase 8
  • Synonyms
    URFA6L
  • Feature Type
    protein coding gene
  • IDs
    MGI:99926
    NCBI Gene: 17706
  • Gene Overview
    MyGene.info: ATP8
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    ATP8, ATP synthase F0 subunit 8
  • Vertebrate Orthologs
    2
  • Human Ortholog
    ATP8, ATP synthase F0 subunit 8
    Orthology source: HGNC
  • Synonyms
    ATPase8, MTATP8
  • Links
    NCBI Gene ID: 4509
    neXtProt AC: NX_P03928

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    1 with human ATP8 associations

Human Disease Mouse Models
       Atp Synthase 8; MTATP8   OMIM: 516070
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Spontaneous
    2
  • Genomic Mutations
    1 involving mt-Atp8
Mice carrying homoplastic mtDNAs with a single point mutation in this gene exhibit increased anxiety-like behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064356 Ensembl Gene Model | MGI Sequence Detail 204 C57BL/6J ±  kb
transcript ENSMUST00000082407 Ensembl | MGI Sequence Detail 204 Not Applicable  
polypeptide ENSMUSP00000080995 Ensembl | MGI Sequence Detail 67 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 52
    Other 52
Other
Accession IDs
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MGD-MRK-16728
References
more
  • Summaries
    All 18
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:192944 Weiss H, et al., The mitochondrial Atp8 mutation induces mitochondrial ROS generation, secretory dysfunction, and beta-cell mass adaptation in conplastic B6-mtFVB mice. Endocrinology. 2012 Oct;153(10):4666-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory