Vcp
Gene Detail

Symbol Name ID

Vcp valosin containing protein MGI:99919

Synonyms

AAA ATPase p97, CDC48, p97, p97/VCP

Feature Type

protein coding gene

Genetic Map

Chromosome 4

22.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:42979963-43000507 bp, - strand From VEGA annotation of GRCm38   20545 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Vcp ± 2 cM)

Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Vcp

Human ortholog

VCP valosin containing protein NCBI Gene ID 7415
Human Synonyms: ALS14, IBMPFD, p97, TERA
Human Chr9:35056065-35072739 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human VCP (2)

Alleles and phenotypes

All alleles(26) : Targeted(5) Gene trapped(21)
 

Homozygous mutation of this gene results in lethality before weaning. Mice homozygous for a knock-in allele exhibit progressive muscle weakness, myopathy, decreased bone density, increased osteoclast genesis, and seizures.

 
Human Diseases Modeled Using Mouse Vcp (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, aggresome assembly, ...
Component	cytoplasm, cytosol, ...
Function	ADP binding, ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (9)   
Theiler Stages: 15, 19, 22, 26

Assay Type	Results
RNA in situ	8
Western blot	2

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(6) cDNA(24)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006688 (Evidence)
Ensembl Gene Model	ENSMUSG00000028452 (Evidence)
Entrez Gene	269523 (Evidence)
DFCI	TC1573645
DoTS	DT.101410055, DT.101703253, DT.103577021, DT.103577022, DT.103577025, DT.111021574, DT.111021588, DT.111021621, DT.55113873, DT.91287343, DT.91308843, DT.91365104, DT.94378954
NIA Mouse Gene Index	U004223, U024980, U340525
EC	3.6.4.6
PDB	1E32, 1R7R, 1S3S, 2PJH, 3CF0, 3CF1, 3CF2, 3CF3
Consensus CDS Project	CCDS18086.1
International Mouse Knockout Project Status	Vcp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006688	VEGA Gene Model | MGI Sequence Detail	20545	C57BL/6J
transcript	OTTMUST00000015330	VEGA | MGI Sequence Detail	3316	Not Applicable
polypeptide	OTTMUSP00000007079	VEGA | MGI Sequence Detail	806	Not Applicable

All sequences(149) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR009010	Aspartate decarboxylase-like fold
InterPro	IPR005938	ATPase, AAA-type, CDC48
InterPro	IPR003960	ATPase, AAA-type, conserved site
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR004201	CDC48, domain 2
InterPro	IPR003338	CDC48, N-terminal subdomain
InterPro	IPR015415	Vps4 oligomerisation, C-terminal
Protein Ontology	PR:000017273	transitional endoplasmic reticulum ATPase

References

(Earliest) J:2369 Egerton M, et al., VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 1992 Oct;11(10):3533-40
(Latest) J:191235 Hauler F, et al., AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19733-8
All references(67)

Other accession IDs

MGD-MRK-16720