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Vcp
Gene Detail
 Symbol
Name
ID
Vcp
valosin containing protein
MGI:99919
Synonyms AAA ATPase p97, CDC48, p97, p97/VCP
Feature Type protein coding gene
Genetic Map
Chromosome 4
22.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:42979963-43000507 bp, - strand
From VEGA annotation of GRCm38

  20545 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Vcp

Human
homologs
Human Homolog VCP, valosin containing protein
NCBI Gene ID 7415
neXtProt AC  NX_P55072
Human Synonyms  ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, p97, TERA
Human Chr (Location)  9p13.3; chr9:35056068-35072742 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human VCP
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(21) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality before weaning. Mice homozygous for a knock-in allele exhibit progressive muscle weakness, myopathy, decreased bone density, increased osteoclast genesis, and seizures.
 
Human Diseases Modeled Using Mouse Vcp (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Vcp interacts with 125 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, aggresome assembly, ...
Component cytoplasm, cytosol, ...
Function ADP binding, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (9)   
Theiler Stages: 15, 19, 22, 26
Assay TypeResults
RNA in situ 8
Western blot 2
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006688 (Evidence)
Ensembl Gene ModelENSMUSG00000028452 (Evidence)
Entrez Gene269523 (Evidence)
DFCITC1573645
DoTSDT.101410055, DT.101703253, DT.103577021, DT.103577022, DT.103577025, DT.111021574, DT.111021588, DT.111021621, DT.55113873, DT.91287343, DT.91308843, DT.91365104, DT.94378954
NIA Mouse Gene IndexU004223, U024980, U340525
EC3.6.4.6
PDB1R7R, 1S3S, 2PJH, 1E32, 3CF0, 3CF1, 3CF2, 3CF3
Consensus CDS ProjectCCDS18086.1
International Mouse Knockout Project StatusVcp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006688 VEGA Gene Model | MGI Sequence Detail 20545 C57BL/6J ±  kb
transcript OTTMUST00000015330 VEGA | MGI Sequence Detail 3316 Not Applicable 
polypeptide OTTMUSP00000007079 VEGA | MGI Sequence Detail 806 Not Applicable 

For the selected sequences
All sequences(149) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR009010 Aspartate decarboxylase-like domain
InterPro IPR005938 ATPase, AAA-type, CDC48
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR004201 CDC48, domain 2
InterPro IPR003338 CDC48, N-terminal subdomain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR015415 Vps4 oligomerisation, C-terminal
Protein Ontology PR:000017273 transitional endoplasmic reticulum ATPase
References (Earliest) J:2369 Egerton M, et al., VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 1992 Oct;11(10):3533-40
(Latest) J:206220 Llewellyn KJ, et al., Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease. Hum Mol Genet. 2014 Mar 1;23(5):1333-44
All references(75)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-16720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory