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Lamb2 Gene Detail
Summary
  • Symbol
    Lamb2
  • Name
    laminin, beta 2
  • Synonyms
    Lamb-2, Lams, npht
  • Feature Type
    protein coding gene
  • IDs
    MGI:99916
    NCBI Gene: 16779
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:108479736-108490530 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10795 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.40 cM, cytoband F1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    LAMB2, laminin subunit beta 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMB2, laminin subunit beta 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAMS, NPHS5
  • Links
    NCBI Gene ID: 3913
    neXtProt AC: NX_P55268
    UniProt: P55268

  • Chr Location
    3p21.31; chr3:49121114-49133166 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1723
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LAMB2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Lamb2 mouse models; 1 with human LAMB2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000050824 VEGA Gene Model | MGI Sequence Detail 10795 C57BL/6J ±  kb
    transcript OTTMUST00000128785 VEGA | MGI Sequence Detail 5629 Not Applicable  
    polypeptide OTTMUSP00000069260 VEGA | MGI Sequence Detail 1799 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      31 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 143
      Genomic 5
      cDNA 136
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298, MGI:3584415
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 34
      Diseases 3
      Gene Ontology 15
      Phenotypes 27
    • Earliest
      J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
    • Latest
      J:263267 Serjanov D, et al., Laminin beta2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation via Dystroglycan. J Neurosci. 2018 Jun 27;38(26):5996-6010

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory