Lamb2
Gene Detail

Symbol Name ID

Lamb2 laminin, beta 2 MGI:99916

Synonyms

Lamb-2, Lams

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.40 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:108479862-108490530 bp, + strand From NCBI annotation of GRCm38   10669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamb2

Human homologs

Human Homolog		LAMB2, laminin, beta 2 (laminin S)
NCBI Gene ID		3913
neXtProt AC		NX_P55268
Human Synonyms		LAMS, NPHS5
Human Chr (Location)		3p21; chr3:49158547-49170599 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LAMB2

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.

 
Human Diseases Modeled Using Mouse Lamb2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	astrocyte development, axon extension involved in regeneration, ...
Component	basal lamina, basement membrane, ...
Function	integrin binding

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (10)    Tissues (8)    Images (3)
Theiler Stages: 11, 24, 26, 28

Assay Type	Results
Immunohistochemistry	10

cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(139) Genomic(5) cDNA(134)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000052911 (Evidence)
Entrez Gene	16779 (Evidence)
UniGene	425599
DFCI	TC1572829
DoTS	DT.492309
NIA Mouse Gene Index	U020777
Consensus CDS Project	CCDS23528.1
International Mouse Knockout Project Status	Lamb2

Sequences

Length	Strain/Species
genomic	16779	NCBI Gene Model | MGI Sequence Detail	10669	C57BL/6J
transcript	NM_008483	RefSeq | MGI Sequence Detail	5624	C57BL/6
polypeptide	Q61292	UniProt | EBI | MGI Sequence Detail	1799	Not Applicable

All sequences(40) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR013015	Laminin IV
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009655	laminin subunit beta-2

Graphical View of Protein Domain Structure

References

(Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:187983 Lopez-Escobar B, et al., Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling. Dev Dyn. 2012 Nov;241(11):1808-15
All references(89)

Other accession IDs

MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298