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Lamb2 Gene Detail
Summary
  • Symbol
    Lamb2
  • Name
    laminin, beta 2
  • Synonyms
    Lamb-2, Lams, npht
  • Feature Type
    protein coding gene
  • IDs
    MGI:99916
    NCBI Gene: 16779
Location & Maps
more
  • Sequence Map
    Chr9:108479736-108490530 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10795 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LAMB2, laminin subunit beta 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMB2, laminin subunit beta 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAMS, NPHS5
  • Links
    NCBI Gene ID: 3913
    neXtProt AC: NX_P55268

  • Chr Location
    3p21; chr3:49121114-49133166 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1723
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LAMB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lamb2 mouse models; 2 with human LAMB2 associations

Human Disease Mouse Models
       Pierson Syndrome   OMIM: 609049 View 2 models
       Nephrotic Syndrome, Type 5, with or without Ocular Abnormalities;   OMIM: 614199
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Transgenic
    2
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050824 VEGA Gene Model | MGI Sequence Detail 10795 C57BL/6J ±  kb
transcript OTTMUST00000128785 VEGA | MGI Sequence Detail 5629 Not Applicable  
polypeptide OTTMUSP00000069260 VEGA | MGI Sequence Detail 1799 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 140
    Genomic 5
    cDNA 134
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298, MGI:3584415
References
more
  • Summaries
    All 92
    Developmental Gene Expression 31
    Diseases 2
    Gene Ontology 14
    Phenotypes 23
  • Earliest
    J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
  • Latest
    J:222851 Chung JJ, et al., Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest. 2015 Jun;125(6):2307-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory