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Lamb2
Gene Detail
 Symbol
Name
ID
Lamb2
laminin, beta 2
MGI:99916
Synonyms Lamb-2, Lams, npht
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.40 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:108479862-108490530 bp, + strand
From NCBI annotation of GRCm38

  10669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lamb2

Human
homologs
Human Homolog LAMB2, laminin, beta 2 (laminin S)
NCBI Gene ID 3913
neXtProt AC  NX_P55268
Human Synonyms  LAMS, NPHS5
Human Chr (Location)  3p21; chr3:49121114-49133166 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LAMB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.
 
Human Diseases Modeled Using Mouse Lamb2 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Lamb2 interacts with 50 markers (Mir15a, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process astrocyte development, axon extension involved in regeneration, ...
Component basal lamina, basement membrane, ...
Function integrin binding
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (10)    Tissues (8)    Images (3)
Theiler Stages: 11, 24, 26, 28
Assay TypeResults
Immunohistochemistry 10
cDNA source data(130)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) Genomic(5) cDNA(134)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000052911 (Evidence)
Entrez Gene16779 (Evidence)
UniGene425599
DFCITC1572829
DoTSDT.492309
NIA Mouse Gene IndexU020777
Consensus CDS ProjectCCDS23528.1
International Mouse Knockout Project StatusLamb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16779 NCBI Gene Model | MGI Sequence Detail 10669 C57BL/6J ±  kb
transcript NM_008483 RefSeq | MGI Sequence Detail 5624 C57BL/6 
polypeptide Q61292 UniProt | EBI | MGI Sequence Detail 1799 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 EGF-like, laminin
InterPro IPR013015 Laminin IV
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009655 laminin subunit beta-2
Graphical View of Protein Domain Structure
References (Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:208069 Bull KR, et al., Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol. 2014 May;233(1):18-26
All references(95)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298, MGI:3584415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory