About   Help   FAQ
Lamb2
Gene Detail
Symbol

Name
ID
Lamb2
laminin, beta 2
MGI:99916
Synonyms
Lamb-2, Lams, npht
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.40 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:108479736-108490530 bp, + strand
From VEGA annotation of GRCm38

  10795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMB2
Gene Tree: Lamb2

Human
homologs
LAMB2, laminin, beta 2 (laminin S)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3913
neXtProt AC: NX_P55268

Human Synonyms: LAMS, NPHS5

Human Chr (Location): 3p21; chr3:49121114-49133166 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LAMB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit small size, severe proteinuria due to a defect in glomerular filtration, abnormalities of the retina and skeletal neuromuscular synapses, and lethality by 30 days of age.
 
Human Diseases Modeled in Mice Using Lamb2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Lamb2 interacts with 50 markers (Mir15a, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process astrocyte development, axon extension involved in regeneration, ...
Component basal lamina, basement membrane, ...
Function integrin binding
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (23)    Tissues (19)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RT-PCR 2
cDNA source data(130)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamb2 ; ZFIN lamb2    NEW 
Molecular
reagents
All nucleic(140) Genomic(5) cDNA(134) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050824 (Evidence)
Ensembl Gene Model ENSMUSG00000052911 (Evidence)
Entrez Gene 16779 (Evidence)
UniGene 425599
DFCI TC1572829
DoTS DT.492309
NIA Mouse Gene Index U020777
Consensus CDS Project CCDS23528.1
International Mouse Phenotyping Consortium Status Lamb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050824 VEGA Gene Model | MGI Sequence Detail 10795 C57BL/6J ±  kb
transcript OTTMUST00000128785 VEGA | MGI Sequence Detail 5629 Not Applicable 
polypeptide OTTMUSP00000069260 VEGA | MGI Sequence Detail 1799 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002049 Laminin EGF domain
InterPro IPR013015 Laminin IV type B
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009655 laminin subunit beta-2
References
(Earliest) J:7978 Elliott RW, et al., Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985 Aug;21(8):477-84
(Latest) J:222851 Chung JJ, et al., Albumin-associated free fatty acids induce macropinocytosis in podocytes. J Clin Invest. 2015 Jun;125(6):2307-16
All references(95)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11736, MGD-MRK-11747, MGD-MRK-16715, MGI:2143298, MGI:3584415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory