Lamc2 MGI Mouse Gene Detail - MGI:99913

Lamc2 Gene Detail

Symbol

Lamc2
Name

laminin, gamma 2
Synonyms

nicein, 100kDa

Feature Type

protein coding gene
IDs

MGI:99913
NCBI Gene: 16782

Sequence Map

Chr1:153122756-153186447 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

63692 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.26 cM, cytoband H1
Mapping Data

15 experiments

Human Ortholog

LAMC2, laminin subunit gamma 2

Vertebrate Orthologs

10

Human Ortholog

LAMC2, laminin subunit gamma 2
Orthology source: HomoloGene, HGNC
Synonyms

B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
Links

HGNC:6493

NCBI Gene ID: 3918

neXtProt AC: NX_Q13753
Chr Location

1q25-q31; chr1:183186039-183245127 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4062
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: LAMC2
Gene Tree

Lamc2

Diseases

2 with Lamc2 mouse models; 2 with human LAMC2 associations

Human Disease

Mouse Models

Epidermolysis Bullosa, Junctional, Herlitz Type OMIM: 226700

View 1 model

Epidermolysis Bullosa, Junctional, Non-Herlitz Type OMIM: 226650

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

27 phenotypes from 2 alleles in 4 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Gene trapped

8
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Lamc2
Incidental Mutations

Mutagenetix , APF

Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.

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All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

156
Tissues

57
cDNA Data

40
Literature Summary

40

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase lamc2

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Lamc2 interacts with 211 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

43
RefSeq

6
UniProt

5
CCDS

CCDS15369.1
UniGene

329272

			Length	Strain/Species	Flank
genomic	OTTMUSG00000049711	VEGA Gene Model \| MGI Sequence Detail	63692	C57BL/6J	± kb
transcript	OTTMUST00000126618	VEGA \| MGI Sequence Detail	4916	Not Applicable
polypeptide	OTTMUSP00000068446	VEGA \| MGI Sequence Detail	1193	Not Applicable

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SNPs within 2kb

848 from dbSNP Build 142

RFLP

2

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UniProt

5 Sequences
Protein Ontology

PR:000009659 laminin subunit gamma-2
InterPro Domains

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR002049 Laminin EGF domain

IPR000034 Laminin IV

IPR031082 Laminin subunit gamma

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All nucleic 49

Genomic 2

cDNA 40

Primer pair 6

Other 1

Microarray probesets 4

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MGD-MRK-16711, MGI:2138115

Summaries

All 81

Developmental Gene Expression 40

Diseases 2

Gene Ontology 6

Phenotypes 11
Earliest

J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
Latest

J:224948 Lin C, et al., A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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