Lamc2 MGI Mouse Gene Detail - MGI:99913

Symbol

Lamc2
Name

laminin, gamma 2
Synonyms

nicein, 100kDa

Feature Type

protein coding gene
IDs

MGI:99913
NCBI Gene: 16782
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:152998502-153062193 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 65.26 cM, cytoband H1
Mapping Data

15 experiments

SNPs within 2kb

842 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99913	protein coding gene	Chr1:152998502-153062193 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016594	protein coding gene	Chr1:157917320-157991328 (-)
A/J	MGP_AJ_G0016576	protein coding gene	Chr1:151552326-151616959 (-)
AKR/J	MGP_AKRJ_G0016541	protein coding gene	Chr1:156242284-156312869 (-)
BALB/cJ	MGP_BALBcJ_G0016536	protein coding gene	Chr1:152119674-152185505 (-)
C3H/HeJ	MGP_C3HHeJ_G0016361	protein coding gene	Chr1:156342588-156410042 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016997	protein coding gene	Chr1:163375286-163447458 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014706	protein coding gene	Chr1:143866178-143928634 (-)
CAST/EiJ	MGP_CASTEiJ_G0015940	protein coding gene	Chr1:155848422-155915639 (-)
CBA/J	MGP_CBAJ_G0016335	protein coding gene	Chr1:169135011-169201924 (-)
DBA/2J	MGP_DBA2J_G0016441	protein coding gene	Chr1:150569135-150633852 (-)
FVB/NJ	MGP_FVBNJ_G0016439	protein coding gene	Chr1:149054141-149118449 (-)
LP/J	MGP_LPJ_G0016512	protein coding gene	Chr1:159035911-159103914 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016465	protein coding gene	Chr1:176765905-176833840 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017033	protein coding gene	Chr1:156026282-156093043 (-)
PWK/PhJ	MGP_PWKPhJ_G0015726	protein coding gene	Chr1:149593292-149660637 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015513	protein coding gene	Chr1:154820239-154888459 (-)
WSB/EiJ	MGP_WSBEiJ_G0016003	protein coding gene	Chr1:156083201-156153287 (-)

Human Ortholog

LAMC2, laminin subunit gamma 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMC2, laminin subunit gamma 2
Synonyms

B2T, BM600, CSF, EBR2, EBR2A, JEB3A, JEB3B, LAMB2T, LAMNB2
Links

HGNC:6493

NCBI Gene ID: 3918

neXtProt AC: NX_Q13753

UniProt: Q13753
Chr Location

1q25.3; chr1:183186039-183245127 (+) GRCh38.p7

Alliance of Genome Resources

Lamc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMC2
Gene Tree

Lamc2

Diseases

2 with Lamc2 mouse models; 1 with human LAMC2 associations

Human Disease

Mouse Models

junctional epidermolysis bullosa Herlitz type

IDs

View 1 model

junctional epidermolysis bullosa non-Herlitz type

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

27 phenotypes from 2 alleles in 4 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Gene trapped

6
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Lamc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

923
Tissues

122
cDNA Data

42
Literature Summary

47

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamc2

ZFIN lamc2

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Lamc2 interacts with 211 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

51
RefSeq

6
UniProt

5
CCDS

CCDS15369.1

Ensembl

ENSMUSG00000026479 (Evidence)
NCBI Gene

16782

Representative Sequences				Length	Strain/Species	Flank
	genomic	16782	NCBI Gene Model \| MGI Sequence Detail	63692	C57BL/6J	± kb

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UniProt

5 Sequences
Protein Ontology

PR:000009659 laminin subunit gamma-2

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR000034 Laminin IV

IPR002049 Laminin-type EGF domain

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All nucleic 51

Genomic 2

cDNA 42

Primer pair 7

Microarray probesets 4

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MGD-MRK-16711, MGI:2138115

Summaries

All 100

Developmental Gene Expression 47

Diseases 2

Gene Ontology 9

Phenotypes 13
Earliest

J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
Latest

J:310487 Xiang C, et al., RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Mol Cell Biol. 2021 Jun 23;41(7):e0052620

TSS for Lamc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14254	Chr1:153061888-153061901 (-)	298 bp
Tssr14253	Chr1:153061871-153061882 (-)	316 bp
Tssr14252	Chr1:153061848-153061868 (-)	335 bp
Tssr14251	Chr1:153061817-153061838 (-)	365 bp
Tssr14250	Chr1:153061757-153061802 (-)	413 bp
Tssr14249	Chr1:153016744-153016749 (-)	45,446 bp
Tssr14248	Chr1:153005828-153005838 (-)	56,360 bp
Tssr14247	Chr1:153002878-153002902 (-)	59,303 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/17/2022 MGI 6.19