Lamc2
Gene Detail

Symbol Name ID

Lamc2 laminin, gamma 2 MGI:99913

Synonyms

nicein, 100kDa

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.26 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr1:153122756-153186447 bp, - strand From NCBI annotation of GRCm38   63692 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamc2

Human homologs

Human Homolog		LAMC2, laminin, gamma 2
NCBI Gene ID		3918
neXtProt AC		NX_Q13753
Human Synonyms		B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
Human Chr (Location)		1q25-q31; chr1:183178827-183258333 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human LAMC2

Alleles and phenotypes

All alleles(12) : Gene trapped(8) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.

 
Human Diseases Modeled Using Mouse Lamc2 (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion
Component	basement membrane, cell cortex, ...
Function	heparin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (38 records)

Data Summary: Results (149)    Tissues (49)    Images (23)
Theiler Stages: 10, 11, 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	84
RT-PCR	48

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(2) cDNA(40) Primer pair(6) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026479 (Evidence)
Entrez Gene	16782 (Evidence)
UniGene	329272
DFCI	TC1583177, TC1700663
DoTS	DT.101364278, DT.529609, DT.91309714, DT.97357086, DT.97391019
Consensus CDS Project	CCDS15369.1
International Mouse Knockout Project Status	Lamc2

Sequences

Length	Strain/Species
genomic	16782	NCBI Gene Model | MGI Sequence Detail	63692	C57BL/6J
transcript	NM_008485	RefSeq | MGI Sequence Detail	5182	C57BL/6
polypeptide	Q61092	UniProt | EBI | MGI Sequence Detail	1191	Not Applicable

All sequences(31) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(2) : SNPs within 2kb(850 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
Protein Ontology	PR:000009659	laminin subunit gamma-2

Graphical View of Protein Domain Structure

References

(Earliest) J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
(Latest) J:191995 Adair-Kirk TL, et al., Keratinocyte-targeted expression of human laminin gamma2 rescues skin blistering and early lethality of laminin gamma2 deficient mice. PLoS One. 2012;7(9):e45546
All references(82)

Other accession IDs

MGD-MRK-16711, MGI:2138115