Lamc2
Gene Detail

Symbol

Name
ID

Lamc2
laminin, gamma 2
MGI:99913

Synonyms

nicein, 100kDa

Feature Type

protein coding gene

Genetic Map

Chromosome 1
65.26 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr1:153122756-153186447 bp, - strand From VEGA annotation of GRCm38   63692 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lamc2

Human
homologs

Human Homolog		LAMC2, laminin, gamma 2
NCBI Gene ID		3918
neXtProt AC		NX_Q13753
Human Synonyms		B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
Human Chr (Location)		1q25-q31; chr1:183178827-183258333 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human LAMC2

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(8) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.

 
Human Diseases Modeled in Mice Using Lamc2 (2)    Mutations Annotated to Human Diseases (2)   

Interactions

Lamc2 interacts with 211 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Process	cell adhesion
Component	basement membrane, cell cortex, ...
Function	heparin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (39 records)

Data Summary: Results (156)    Tissues (57)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	24
RNA in situ	84
RT-PCR	48

cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(49) Genomic(2) cDNA(40) Primer pair(6) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000049711 (Evidence)
Ensembl Gene Model	ENSMUSG00000026479 (Evidence)
Entrez Gene	16782 (Evidence)
UniGene	329272
DFCI	TC1583177, TC1700663
DoTS	DT.101364278, DT.529609, DT.91309714, DT.97357086, DT.97391019
Consensus CDS Project	CCDS15369.1
International Mouse Knockout Project Status	Lamc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000049711	VEGA Gene Model | MGI Sequence Detail	63692	C57BL/6J
transcript	OTTMUST00000126618	VEGA | MGI Sequence Detail	4916	Not Applicable
polypeptide	OTTMUSP00000068446	VEGA | MGI Sequence Detail	1193	Not Applicable

All sequences(50) RefSeq(6) UniProt(5)

Polymorphisms

RFLP(2) : SNPs within 2kb(850 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
Protein Ontology	PR:000009659	laminin subunit gamma-2

References

(Earliest) J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
(Latest) J:211010 Sproule TJ, et al., Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice. PLoS Genet. 2014 Feb;10(2):e1004068
All references(85)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-16711, MGI:2138115