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Lamc2 Gene Detail
Summary
  • Symbol
    Lamc2
  • Name
    laminin, gamma 2
  • Synonyms
    nicein, 100kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:99913
    NCBI Gene: 16782
Location & Maps
more
  • Sequence Map
    Chr1:153122756-153186447 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63692 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LAMC2, laminin subunit gamma 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMC2, laminin subunit gamma 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
  • Links
    NCBI Gene ID: 3918
    neXtProt AC: NX_Q13753

  • Chr Location
    1q25-q31; chr1:183186039-183245127 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4062
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LAMC2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Lamc2 mouse models; 2 with human LAMC2 associations

Human Disease Mouse Models
       Epidermolysis Bullosa, Junctional, Herlitz Type   OMIM: 226700 View 1 model
Epidermolysis Bullosa, Junctional, Non-Herlitz Type   OMIM: 226650 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Lamc2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049711 VEGA Gene Model | MGI Sequence Detail 63692 C57BL/6J ±  kb
transcript OTTMUST00000126618 VEGA | MGI Sequence Detail 4916 Not Applicable  
polypeptide OTTMUSP00000068446 VEGA | MGI Sequence Detail 1193 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    848 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    Genomic 2
    cDNA 40
    Primer pair 6
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-16711, MGI:2138115
References
more
  • Summaries
    All 81
    Developmental Gene Expression 40
    Diseases 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
  • Latest
    J:224948 Lin C, et al., A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory