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Lamc2
Gene Detail
Symbol

Name
ID
Lamc2
laminin, gamma 2
MGI:99913
Synonyms
nicein, 100kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.26 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr1:153122756-153186447 bp, - strand
From VEGA annotation of GRCm38

  63692 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4062  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMC2
Gene Tree: Lamc2

Human
homologs
LAMC2, laminin, gamma 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3918
neXtProt AC: NX_Q13753

Human Synonyms: B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2

Human Chr (Location): 1q25-q31; chr1:183186039-183245127 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LAMC2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.
 
Human Diseases Modeled in Mice Using Lamc2 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Lamc2 interacts with 211 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell adhesion
Component basement membrane, cell cortex, ...
Function heparin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (156)    Tissues (57)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 84
RT-PCR 48
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamc2    NEW 
Molecular
reagents
All nucleic(49) Genomic(2) cDNA(40) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049711 (Evidence)
Ensembl Gene Model ENSMUSG00000026479 (Evidence)
Entrez Gene 16782 (Evidence)
UniGene 329272
DFCI TC1583177, TC1700663
DoTS DT.101364278, DT.529609, DT.91309714, DT.97357086, DT.97391019
Consensus CDS Project CCDS15369.1
International Mouse Phenotyping Consortium Status Lamc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049711 VEGA Gene Model | MGI Sequence Detail 63692 C57BL/6J ±  kb
transcript OTTMUST00000126618 VEGA | MGI Sequence Detail 4916 Not Applicable 
polypeptide OTTMUSP00000068446 VEGA | MGI Sequence Detail 1193 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(850 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
Protein Ontology PR:000009659 laminin subunit gamma-2
References
(Earliest) J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
(Latest) J:211010 Sproule TJ, et al., Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice. PLoS Genet. 2014 Feb;10(2):e1004068
All references(82)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16711, MGI:2138115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory