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Lamc2 Gene Detail
Summary
  • Symbol
    Lamc2
  • Name
    laminin, gamma 2
  • Synonyms
    nicein, 100kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:99913
    NCBI Gene: 16782
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:153122756-153186447 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      63692 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.26 cM, cytoband H1
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    LAMC2, laminin subunit gamma 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMC2, laminin subunit gamma 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
  • Links
    NCBI Gene ID: 3918
    neXtProt AC: NX_Q13753
    UniProt: Q13753

  • Chr Location
    1q25.3; chr1:183186039-183245127 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4062
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LAMC2
  • Gene Tree
    Lamc2
Human Diseases
more
  • Diseases
    2 with Lamc2 mouse models; 2 with human LAMC2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in cell:cell adhesion involving epithelial cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    215
  • Tissues
    91
  • cDNA Data
    41
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000049711 VEGA Gene Model | MGI Sequence Detail 63692 C57BL/6J ±  kb
    transcript OTTMUST00000126618 VEGA | MGI Sequence Detail 4916 Not Applicable  
    polypeptide OTTMUSP00000068446 VEGA | MGI Sequence Detail 1193 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      848 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 41
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16711, MGI:2138115
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 45
      Diseases 2
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:17618 Aberdam D, et al., Assignment of mouse nicein genes to chromosomes 1 and 18. Mamm Genome. 1994 Apr;5(4):229-33
    • Latest
      J:251718 Pietila I, et al., Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS One. 2016;11(1):e0147171
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory