Lama3
Gene Detail

Symbol Name ID

Lama3 laminin, alpha 3 MGI:99909

Synonyms

[a]3B, nicein, 150kDa

Feature Type

protein coding gene

Genetic Map

Chromosome 18

6.20 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr18:12334024-12583013 bp, + strand From NCBI annotation of GRCm38   248990 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Lama3

Human homologs

Human Homolog		LAMA3, laminin, alpha 3
NCBI Gene ID		3909
neXtProt AC		NX_Q16787
Human Synonyms		BM600, E170, lama3a, LAMNA, LOCS
Human Chr (Location)		18q11.2; chr18:21269562-21535030 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human LAMA3

Alleles and phenotypes

All alleles(11) : Targeted(1) Gene trapped(10)
 

Mice homozygous for a targeted null mutation develop a lethal blistering phenotype similar to human junctional epidermolysis bullosa, and die 2-3 days after birth from a failure to thrive.

 
Human Diseases Modeled Using Mouse Lama3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell adhesion, cell-cell adhesion, ...
Component	basement membrane, cell-cell adherens junction, ...
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (119)    Tissues (28)    Images (25)
Theiler Stages: 11, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	107

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(6) cDNA(31) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024421 (Evidence)
Entrez Gene	16774 (Evidence)
UniGene	42012
DFCI	TC1585787, TC1637740, TC1769923
DoTS	DT.110750046, DT.55108412, DT.55166423, DT.94237257, DT.94237258
NIA Mouse Gene Index	U040834
Consensus CDS Project	CCDS50222.1
International Mouse Knockout Project Status	Lama3

Sequences

Length	Strain/Species
genomic	16774	NCBI Gene Model | MGI Sequence Detail	248990	C57BL/6J
transcript	NM_010680	RefSeq | MGI Sequence Detail	10343	C57BL/6
polypeptide	Q61789	UniProt | EBI | MGI Sequence Detail	3333	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(1250 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR001791	Laminin G domain
InterPro	IPR009254	Laminin I
InterPro	IPR010307	Laminin II
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009652	laminin subunit alpha-3

Graphical View of Protein Domain Structure

References

(Earliest) J:24448 Marinkovich MP, et al., The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 1992 Nov;119(3):695-703
(Latest) J:187983 Lopez-Escobar B, et al., Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: Implications for regulation of BMP signalling. Dev Dyn. 2012 Nov;241(11):1808-15
All references(74)

Other accession IDs

MGD-MRK-16706