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Lama3
Gene Detail
Symbol

Name
ID
Lama3
laminin, alpha 3
MGI:99909
Synonyms
[a]3B, nicein, 150kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 18
6.20 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr18:12333819-12583013 bp, + strand
From VEGA annotation of GRCm38

  249195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Lama3

Human
homologs
Human Homolog LAMA3, laminin, alpha 3
NCBI Gene ID 3909
neXtProt AC  NX_Q16787
Human Synonyms  BM600, E170, lama3a, LAMNA, LOCS
Human Chr (Location)  18q11.2; chr18:23689598-23955066 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human LAMA3
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(10) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation develop a lethal blistering phenotype similar to human junctional epidermolysis bullosa, and die 2-3 days after birth from a failure to thrive.
 
Human Diseases Modeled Using Mouse Lama3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)
Interactions
Lama3 interacts with 201 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, hemidesmosome assembly, ...
Component basement membrane, cell-cell adherens junction, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (126)    Tissues (35)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 107
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(6) cDNA(30) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000045059 (Evidence)
Ensembl Gene ModelENSMUSG00000024421 (Evidence)
Entrez Gene16774 (Evidence)
UniGene42012
DFCITC1585787, TC1637740, TC1769923
DoTSDT.110750046, DT.55108412, DT.55166423, DT.94237257, DT.94237258
NIA Mouse Gene IndexU040834
Consensus CDS ProjectCCDS50222.1
International Mouse Knockout Project StatusLama3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045059 VEGA Gene Model | MGI Sequence Detail 249195 C57BL/6J ±  kb
transcript OTTMUST00000118410 VEGA | MGI Sequence Detail 10548 Not Applicable 
polypeptide OTTMUSP00000066092 VEGA | MGI Sequence Detail 3330 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(17) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(1909 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009652 laminin subunit alpha-3
References
(Earliest) J:24448 Marinkovich MP, et al., The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 1992 Nov;119(3):695-703
(Latest) J:202984 Rockich BE, et al., Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
All references(76)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16706

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory