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Tie1
Gene Detail
Symbol

Name
ID
Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
MGI:99906
Synonyms
D430008P04Rik, TIE, tie-1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
54.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr4:118471191-118490061 bp, - strand
From VEGA annotation of GRCm38

  18871 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein-tyrosine kinase, receptor type tie
Gene Tree: Tie1

Human
homologs
Human Homolog TIE1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1
NCBI Gene ID 7075
neXtProt AC  NX_P35590
Human Synonyms  JTK14, TIE
Human Chr (Location)  1p34-p33; chr1:43300895-43323110 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic or neonatal lethality, hemorrhages, edema, increased vascular branching, and abnormal vascular endothelial cell development. Mice homozygous for a hypomorphic allele exhibit dilated and disorganized lymphatic vessel, edema, and hemorrhage.
 
Interactions
Tie1 interacts with 50 markers (Mir27a, Mir27b, Mir125a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process angiogenesis, blood vessel development, ...
Component integral component of membrane, membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (65 records)
Data Summary: Results (92)    Tissues (45)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
In situ reporter (knock in) 9
Northern blot 9
Western blot 2
RT-PCR 41
RNase protection 4
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) Genomic(1) cDNA(42) Primer pair(10) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008793 (Evidence)
Ensembl Gene ModelENSMUSG00000033191 (Evidence)
Entrez Gene21846 (Evidence)
UniGene4345
DFCITC1580260, TC1597163, TC1631089
DoTSDT.101725406, DT.40174117
NIA Mouse Gene IndexU025449
EC2.7.10.1
Consensus CDS ProjectCCDS18553.1
International Mouse Knockout Project StatusTie1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008793 VEGA Gene Model | MGI Sequence Detail 18871 C57BL/6J ±  kb
transcript OTTMUST00000019990 VEGA | MGI Sequence Detail 4091 Not Applicable 
polypeptide OTTMUSP00000009169 VEGA | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000016330 tyrosine-protein kinase receptor Tie-1
References
(Earliest) J:193673 Korhonen J, et al., Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization. Blood. 1992 Nov 15;80(10):2548-55
(Latest) J:207983 D'Amico G, et al., Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest. 2014 Feb 3;124(2):824-34
All references(117)
Other
accession IDs
MGD-MRK-16703, MGI:2443090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory