Lama1
Gene Detail

Symbol Name ID

Lama1 laminin, alpha 1 MGI:99892

Synonyms

Lama

Feature Type

protein coding gene

Genetic Map

Chromosome 17

38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr17:67697265-67822645 bp, + strand From NCBI annotation of GRCm38   125381 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Lama1

Human homologs

Human Homolog		LAMA1, laminin, alpha 1
NCBI Gene ID		284217
neXtProt AC		NX_P25391
Human Synonyms		LAMA, S-LAM-alpha
Human Chr (Location)		18p11.3; chr18:6941743-7117813 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(10) Gene trapped(4) Chemically induced(1)
 

Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.

 
Phenotype Images(8)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	branching involved in salivary gland morphogenesis, cell adhesion, ...
Component	basal lamina, basement membrane, ...
Function	extracellular matrix structural constituent, glycosphingolipid binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (112 records)
Data Summary: Results (340)    Tissues (151)    Images (65)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 17, 18, 19, 20, 21, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	40
RNA in situ	249
Northern blot	23
RT-PCR	28

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032796 (Evidence)
Entrez Gene	16772 (Evidence)
DFCI	TC1578025, TC1608082
DoTS	DT.101252360, DT.110553487, DT.531050, DT.91334798
NIA Mouse Gene Index	U018186, U104356
PDB	2JD4
Consensus CDS Project	CCDS37681.1
International Mouse Knockout Project Status	Lama1

Sequences

Length	Strain/Species
genomic	16772	NCBI Gene Model | MGI Sequence Detail	125381	C57BL/6J
transcript	NM_008480	RefSeq | MGI Sequence Detail	9518	C57BL/6
polypeptide	P19137	UniProt | EBI | MGI Sequence Detail	3084	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(125 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR001791	Laminin G domain
InterPro	IPR009254	Laminin I
InterPro	IPR010307	Laminin II
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009650	laminin subunit alpha-1

Graphical View of Protein Domain Structure

References

(Earliest) J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
(Latest) J:189883 Kim ST, et al., Functional consequences of cell type-restricted expression of laminin alpha5 in mouse placental labyrinth and kidney glomerular capillaries. PLoS One. 2012;7(7):e41348
All references(207)

Other accession IDs

MGD-MRK-11733, MGD-MRK-16687, MGI:2146751