About   Help   FAQ
Lama1
Gene Detail
Symbol

Name
ID
Lama1
laminin, alpha 1
MGI:99892
Synonyms
Lama
Feature Type
protein coding gene
Genetic Map
Chromosome 17
38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:67697265-67822645 bp, + strand
From NCBI annotation of GRCm38

  125381 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lama1

Human
homologs
Human Homolog LAMA1, laminin, alpha 1
NCBI Gene ID 284217
neXtProt AC  NX_P25391
Human Synonyms  LAMA, PTBHS, S-LAM-alpha
Human Chr (Location)  18p11.3; chr18:6941744-7117814 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.
 
Phenotype Images(8)
Interactions
Lama1 interacts with 127 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (116 records)
Data Summary: Results (417)    Tissues (210)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 98
RNA in situ 278
Northern blot 20
RT-PCR 21
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032796 (Evidence)
Entrez Gene16772 (Evidence)
DFCITC1578025, TC1608082
DoTSDT.101252360, DT.110553487, DT.531050, DT.91334798
NIA Mouse Gene IndexU018186, U104356
PDB2JD4
Consensus CDS ProjectCCDS37681.1
International Mouse Knockout Project StatusLama1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16772 NCBI Gene Model | MGI Sequence Detail 125381 C57BL/6J ±  kb
transcript NM_008480 RefSeq | MGI Sequence Detail 9518 C57BL/6 
polypeptide P19137 UniProt | EBI | MGI Sequence Detail 3084 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(741 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009650 laminin subunit alpha-1
Graphical View of Protein Domain Structure
References
(Earliest) J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
(Latest) J:210959 Ning L, et al., Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway. Am J Pathol. 2014 Jun;184(6):1683-94
All references(215)
Other
accession IDs
MGD-MRK-11733, MGD-MRK-16687, MGI:2146751

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory