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Lama1
Gene Detail
 Symbol
Name
ID
Lama1
laminin, alpha 1
MGI:99892
Synonyms Lama
Feature Type protein coding gene
Genetic Map
Chromosome 17
38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:67697265-67822645 bp, + strand
From NCBI annotation of GRCm38

  125381 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Lama1

Human
homologs
Human Homolog LAMA1, laminin, alpha 1
NCBI Gene ID 284217
neXtProt AC  NX_P25391
Human Synonyms  LAMA, S-LAM-alpha
Human Chr (Location)  18p11.3; chr18:6941744-7117814 (-)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Targeted(10) Gene trapped(4) Chemically induced(1)
 
Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.
 
Phenotype Images(8)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process branching involved in salivary gland morphogenesis, cell adhesion, ...
Component basal lamina, basement membrane, ...
Function extracellular matrix structural constituent, glycosphingolipid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (115 records)
Data Summary: Results (410)    Tissues (209)    Images (86)
Theiler Stages: 1, 2, 3, 4, 11, 13, 15, 17, 18, 19, 20, 21, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 81
RNA in situ 278
Northern blot 23
RT-PCR 28
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032796 (Evidence)
Entrez Gene16772 (Evidence)
DFCITC1578025, TC1608082
DoTSDT.531050, DT.101252360, DT.110553487, DT.91334798
NIA Mouse Gene IndexU018186, U104356
PDB2JD4
Consensus CDS ProjectCCDS37681.1
International Mouse Knockout Project StatusLama1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16772 NCBI Gene Model | MGI Sequence Detail 125381 C57BL/6J ±  kb
transcript NM_008480 RefSeq | MGI Sequence Detail 9518 C57BL/6 
polypeptide P19137 UniProt | EBI | MGI Sequence Detail 3084 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(741 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009650 laminin subunit alpha-1
Graphical View of Protein Domain Structure
References (Earliest) J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
(Latest) J:202984 Rockich BE, et al., Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
All references(212)
Other
accession IDs
MGD-MRK-11733, MGD-MRK-16687, MGI:2146751

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory