About   Help   FAQ
Lama1
Gene Detail
Symbol

Name
ID
Lama1
laminin, alpha 1
MGI:99892
Synonyms
Lama
Feature Type
protein coding gene
Genetic Map
Chromosome 17
38.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr17:67697265-67822645 bp, + strand
From Ensembl annotation of GRCm38

  125381 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21146  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMA1
Gene Tree: Lama1

Human
homologs
LAMA1, laminin, alpha 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 284217
neXtProt AC: NX_P25391

Human Synonyms: LAMA, PTBHS, S-LAM-alpha

Human Chr (Location): 18p11.3; chr18:6941744-7117814 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.
 
Phenotype Images(8)
Interactions
Lama1 interacts with 127 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (118 records)
Data Summary: Results (419)    Tissues (211)    Images (94)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 98
RNA in situ 278
Northern blot 20
RT-PCR 23
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lama1 ; ZFIN lama1    NEW 
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032796 (Evidence)
Entrez Gene 16772 (Evidence)
DFCI TC1578025, TC1608082
DoTS DT.101252360, DT.110553487, DT.531050, DT.91334798
NIA Mouse Gene Index U018186, U104356
PDB 2JD4
Consensus CDS Project CCDS37681.1
International Mouse Phenotyping Consortium Status Lama1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032796 Ensembl Gene Model | MGI Sequence Detail 125381 C57BL/6J ±  kb
transcript ENSMUST00000035471 Ensembl | MGI Sequence Detail 9518 Not Applicable 
polypeptide ENSMUSP00000043957 Ensembl | MGI Sequence Detail 3083 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(741 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009650 laminin subunit alpha-1
References
(Earliest) J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
(Latest) J:210959 Ning L, et al., Laminin alpha1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-beta pathway. Am J Pathol. 2014 Jun;184(6):1683-94
All references(216)
Other
accession IDs
MGD-MRK-11733, MGD-MRK-16687, MGI:2146751

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory