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Cbfb
Gene Detail
Symbol

Name
ID
Cbfb
core binding factor beta
MGI:99851
Synonyms
PEA2, Pebp2, PEBP2b, Pebpb2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:105170674-105217989 bp, + strand
From VEGA annotation of GRCm38

  47316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CBFB
Protein SuperFamily: core-binding factor, beta subunit
Gene Tree: Cbfb

Human
homologs
CBFB, core-binding factor, beta subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 865
neXtProt AC: NX_Q13951

Human Synonyms: PEBP2B

Human Chr (Location): 16q22.1; chr16:67029147-67101058 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(17) Targeted(14) Transgenic(1)
Incidental mutations (data from CvDC )
 
Homozygous null mutant embryos exhibit massive CNS hemorrhaging, impaired definitive hematopoiesis, and death around E12.5. Homozygotes for a hypoplastic mutation are born at normal ratios but die soon after birth. Delayed skeletal development leaves bones poorly ossified and hypoplastic at birth.
 
Interactions
Cbfb interacts with 342 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell maturation, definitive hemopoiesis, ...
Component membrane, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (156)    Tissues (133)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 109
Northern blot 8
Western blot 8
RT-PCR 31
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CBFB ; Xenbase cbfb ; ZFIN cbfb    NEW 
Molecular
reagents
All nucleic(146) Genomic(3) cDNA(139) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049550 (Evidence)
Ensembl Gene Model ENSMUSG00000031885 (Evidence)
Entrez Gene 12400 (Evidence)
UniGene 2018
DFCI TC1572768, TC1586676, TC1740555, TC1776379
DoTS DT.101386105, DT.101386106, DT.101386107, DT.101386110, DT.534648, DT.94409156, DT.97362828
NIA Mouse Gene Index U009738
PDB 1ILF, 2JHB, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 1IO4
Consensus CDS Project CCDS22592.1, CCDS52654.1, CCDS52655.1, CCDS52656.1
International Mouse Phenotyping Consortium Status Cbfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049550 VEGA Gene Model | MGI Sequence Detail 47316 C57BL/6J ±  kb
transcript OTTMUST00000126293 VEGA | MGI Sequence Detail 2883 Not Applicable 
polypeptide OTTMUSP00000068322 VEGA | MGI Sequence Detail 187 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003417 Core binding factor, beta subunit
Protein Ontology PR:000005069 core-binding factor subunit beta
References
(Earliest) J:11868 Wang S, et al., Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993 Jun;13(6):3324-39
(Latest) J:219655 Wang CQ, et al., Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis. Leukemia. 2015 Mar;29(3):753-7
All references(105)
Other
accession IDs
MGD-MRK-16642, MGD-MRK-19426, MGI:2142649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory