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Cbfb
Gene Detail
 Symbol
Name
ID
Cbfb
core binding factor beta
MGI:99851
Synonyms PEA2, Pebp2, PEBP2b, Pebpb2
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:105170674-105217989 bp, + strand
From VEGA annotation of GRCm38

  47316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: core-binding factor, beta subunit
Gene Tree: Cbfb

Human
homologs
Human Homolog CBFB, core-binding factor, beta subunit
NCBI Gene ID 865
neXtProt AC  NX_Q13951
Human Synonyms  PEBP2B
Human Chr (Location)  16q22.1; chr16:67029147-67101058 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(17) Targeted(14) Transgenic(1)
 
Homozygous null mutant embryos exhibit massive CNS hemorrhaging, impaired definitive hematopoiesis, and death around E12.5. Homozygotes for a hypoplastic mutation are born at normal ratios but die soon after birth. Delayed skeletal development leaves bones poorly ossified and hypoplastic at birth.
 
Interactions
Cbfb interacts with 342 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell maturation, definitive hemopoiesis, ...
Component membrane, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (156)    Tissues (133)    Images (18)
Theiler Stages: 15, 17, 19, 20, 22, 26, 27, 28
Assay TypeResults
RNA in situ 109
Northern blot 8
Western blot 8
RT-PCR 31
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(146) Genomic(3) cDNA(139) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049550 (Evidence)
Ensembl Gene ModelENSMUSG00000031885 (Evidence)
Entrez Gene12400 (Evidence)
UniGene2018
DFCITC1572768, TC1586676, TC1740555, TC1776379
DoTSDT.101386105, DT.101386106, DT.101386107, DT.101386110, DT.534648, DT.94409156, DT.97362828
NIA Mouse Gene IndexU009738
PDB1ILF, 2JHB, 1IO4
Consensus CDS ProjectCCDS22592.1, CCDS52654.1, CCDS52655.1, CCDS52656.1
International Mouse Knockout Project StatusCbfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049550 VEGA Gene Model | MGI Sequence Detail 47316 C57BL/6J ±  kb
transcript OTTMUST00000126293 VEGA | MGI Sequence Detail 2883 Not Applicable 
polypeptide OTTMUSP00000068322 VEGA | MGI Sequence Detail 187 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003417 Core binding factor, beta subunit
Protein Ontology PR:000005069 core-binding factor subunit beta
References (Earliest) J:11868 Wang S, et al., Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993 Jun;13(6):3324-39
(Latest) J:211343 Chen W, et al., Cbfbeta deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfbeta required for skeletal development. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8482-7
All references(101)
Other
accession IDs
MGD-MRK-16642, MGD-MRK-19426, MGI:2142649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory