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Ryr3 Gene Detail
Summary
  • Symbol
    Ryr3
  • Name
    ryanodine receptor 3
  • Synonyms
    calcium release channel isoform 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99684
    NCBI Gene: 20192
  • Gene Overview
    MyGene.info: RYR3
Location & Maps
more
  • Sequence Map
    Chr2:112631355-113217096 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      585742 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.20 cM, cytoband E5-F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RYR3, ryanodine receptor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RYR3, ryanodine receptor 3
    Orthology source: HomoloGene
  • Synonyms
    RYR-3
  • Links
    NCBI Gene ID: 6263
    neXtProt AC: NX_Q15413

  • Chr Location
    15q13.3; chr15:33310783-33866103 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Ryr3
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired muscle contraction at an early age, changes in hippocampal synaptic plasticity, increased locomotor activity with a tendency to circle, and impaired relearning of a spatial task.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015132 VEGA Gene Model | MGI Sequence Detail 585742 C57BL/6J ±  kb
transcript OTTMUST00000035884 VEGA | MGI Sequence Detail 15468 Not Applicable  
polypeptide OTTMUSP00000016105 VEGA | MGI Sequence Detail 4868 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2674 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 16
    Genomic 5
    cDNA 10
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-16469, MGI:2139082
References
more
  • Summaries
    All 79
    Developmental Gene Expression 15
    Gene Ontology 8
    Phenotypes 27
  • Earliest
    J:37396 Steck TL, The organization of proteins in the human red blood cell membrane. A review. J Cell Biol. 1974 Jul;62(1):1-19
  • Latest
    J:225736 Payne S, et al., A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015 Sep 1;405(1):82-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory