About   Help   FAQ
Adcy5
Gene Detail
Symbol

Name
ID
Adcy5
adenylate cyclase 5
MGI:99673
Synonyms
AC5
Feature Type
protein coding gene
Genetic Map
Chromosome 16
24.71 cM, cytoband B-5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:35155636-35304549 bp, + strand
From NCBI annotation of GRCm38

  148914 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy5

Human
homologs
Human Homolog ADCY5, adenylate cyclase 5
NCBI Gene ID 111
neXtProt AC  NX_O95622
Human Synonyms  AC5, FDFM
Human Chr (Location)  3q21.1; chr3:123282296-123449077 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADCY5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted inactivation of this gene has been shown to result in motor dysfunction.
 
Interactions
Adcy5 interacts with 295 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (265)    Tissues (218)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 219
RT-PCR 46
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000022840 (Evidence)
Entrez Gene224129 (Evidence)
UniGene41137
DFCITC1574016, TC1726124
DoTSDT.55111830
NIA Mouse Gene IndexU043517
EC4.6.1.1
Consensus CDS ProjectCCDS37322.1
International Mouse Knockout Project StatusAdcy5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 224129 NCBI Gene Model | MGI Sequence Detail 148914 C57BL/6J ±  kb
transcript NM_001012765 RefSeq | MGI Sequence Detail 5060 C57BL/6 
polypeptide P84309 UniProt | EBI | MGI Sequence Detail 1262 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(769 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009398 Adenylate cyclase-like
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003756 adenylate cyclase type 5
Graphical View of Protein Domain Structure
References
(Earliest) J:46603 Premont RT, et al., Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9809-13
(Latest) J:213288 Timofeyev V, et al., Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes. Circ Res. 2013 Jun 7;112(12):1567-76
All references(63)
Other
accession IDs
MGD-MRK-16458, MGI:2146623

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory