Adcy5
Gene Detail

Symbol Name ID

Adcy5 adenylate cyclase 5 MGI:99673

Synonyms

AC5

Feature Type

protein coding gene

Genetic Map

Chromosome 16

24.71 cM, cytoband B-5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:35155636-35304549 bp, + strand From NCBI annotation of GRCm38   148914 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adcy5

Human homologs

Human Homolog		ADCY5, adenylate cyclase 5
NCBI Gene ID		111
neXtProt AC		NX_O95622
Human Synonyms		AC5, FDFM
Human Chr (Location)		3q21.1; chr3:123001143-123167392 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADCY5

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Targeted inactivation of this gene has been shown to result in motor dysfunction.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	adenosine receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, ...
Component	cell projection, cilium, ...
Function	adenylate cyclase activity, adenylate cyclase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (216)    Tissues (169)    Images (29)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	170
RT-PCR	46

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(43) Primer pair(1) Other(1)
Microarray probesets(8)

Other database links

Ensembl Gene Model	ENSMUSG00000022840 (Evidence)
Entrez Gene	224129 (Evidence)
UniGene	41137
DFCI	TC1574016, TC1726124
DoTS	DT.55111830
NIA Mouse Gene Index	U043517
EC	4.6.1.1
Consensus CDS Project	CCDS37322.1
International Mouse Knockout Project Status	Adcy5

Sequences

Length	Strain/Species
genomic	224129	NCBI Gene Model | MGI Sequence Detail	148914	C57BL/6J
transcript	NM_001012765	RefSeq | MGI Sequence Detail	5060	C57BL/6
polypeptide	P84309	UniProt | EBI | MGI Sequence Detail	1262	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(574 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009398	Adenylate cyclase-like
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology	PR:000003756	adenylate cyclase type 5

Graphical View of Protein Domain Structure

References

(Earliest) J:46603 Premont RT, et al., Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9809-13
(Latest) J:193552 Kim KS, et al., The dorsal striatum expressing adenylyl cyclase-5 controls behavioral sensitivity of the righting reflex to high-dose ethanol. Brain Res. 2012 Dec 13;1489:27-36
All references(58)

Other accession IDs

MGD-MRK-16458, MGI:2146623