Adcy5^tm1Yish
Targeted Allele Detail

Summary

• Symbol: Adcy5^tm1Yish
• Name: adenylate cyclase 5; targeted mutation 1, Yoshihiro Ishikawa
• MGI ID: MGI:2662295
• Synonyms: AC5^-, AC5KO, AC5 KO
• Gene: Adcy5 Location: Chr16:34975247-35126108 bp, + strand Genetic Position: Chr16, 24.71 cM, cytoband B-5
• Alliance: Adcy5^tm1Yish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by a neomycin selection inserted by homologous recombination. A putative additional downstream translational start site was deleted upon recombination of the targeting vector. (J:83301)

Disease models

Expression

In Mice Carrying this Mutation:

25 assay results

Tumor Data

List all tumor models in MMHCdb carrying Adcy5^tm1Yish

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy5 Mutation: 66 strains or lines available

References

• Original: J:83301 Iwamoto T, et al., Motor dysfunction in type 5 adenylyl cyclase-null mice. J Biol Chem. 2003 May 9;278(19):16936-40
• All: 24 reference(s)