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Syt2
Gene Detail
Symbol

Name
ID
Syt2
synaptotagmin II
MGI:99666
Feature Type
protein coding gene
Genetic Map
Chromosome 1
58.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:134646677-134762593 bp, + strand
From VEGA annotation of GRCm38

  115917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SYT2
Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt2

Human
homologs
SYT2, synaptotagmin II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 127833
neXtProt AC: NX_Q8N9I0

Human Synonyms: CMS7, MYSPC, SytII

Human Chr (Location): 1q32.1; chr1:202587637-202710444 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SYT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (other)(1) Gene trapped(2) Targeted(5)
 
Mice homozygous for an ENU-induced allele are viable but sterile, weigh less and show ataxia and altered spontaneous and Ca2+-evoked neurotransmitter release. Mice homozygous for a null allele die at weaning showing growth arrest, motor dysfunction and impaired Ca2+-evoked neurotransmitter release.
 
Interactions
Syt2 interacts with 401 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, neurotransmitter secretion, ...
Component cell junction, cytoplasm, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (139)    Tissues (101)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase syt2    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000029462 (Evidence)
Ensembl Gene Model ENSMUSG00000026452 (Evidence)
Entrez Gene 20980 (Evidence)
UniGene 5102
DFCI TC1587594, TC1587914, TC1647342, TC1669655
DoTS DT.101347413, DT.55164625, DT.99823174
NIA Mouse Gene Index U000833
PDB 2NP0, 4KBB
Consensus CDS Project CCDS15312.1
International Mouse Phenotyping Consortium Status Syt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029462 VEGA Gene Model | MGI Sequence Detail 115917 C57BL/6J ±  kb
transcript OTTMUST00000126827 VEGA | MGI Sequence Detail 3386 Not Applicable 
polypeptide OTTMUSP00000068564 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(1646 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR001565 Synaptotagmin
InterPro IPR030543 Synaptotagmin-2
Protein Ontology PR:000015904 synaptotagmin-2
References
(Earliest) J:1973 Willison K, The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990 Apr;6(4):104-5
(Latest) J:216501 Babai N, et al., An alien divalent ion reveals a major role for Ca(2)(+) buffering in controlling slow transmitter release. J Neurosci. 2014 Sep 17;34(38):12622-35
All references(71)
Other
accession IDs
MGD-MRK-16451, MGI:2138727

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory