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Syt2
Gene Detail
 Symbol
Name
ID
Syt2
synaptotagmin II
MGI:99666
Feature Type protein coding gene
Genetic Map
Chromosome 1
58.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:134646677-134762593 bp, + strand
From VEGA annotation of GRCm38

  115917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: B/K protein/synaptotagmin
Gene Tree: Syt2

Human
homologs
Human Homolog SYT2, synaptotagmin II
NCBI Gene ID 127833
neXtProt AC  NX_Q8N9I0
Human Synonyms  SytII
Human Chr (Location)  1q32.1; chr1:202590596-202710423 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (other)(1) Gene trapped(2) Targeted(4)
 
Mice homozygous for an ENU-induced allele are viable but sterile, weigh less and show ataxia and altered spontaneous and Ca2+-evoked neurotransmitter release. Mice homozygous for a null allele die at weaning showing growth arrest, motor dysfunction and impaired Ca2+-evoked neurotransmitter release.
 
Interactions
Syt2 interacts with 402 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process transport
Component cell junction, cytoplasm, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (139)    Tissues (101)    Images (33)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 139
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029462 (Evidence)
Ensembl Gene ModelENSMUSG00000026452 (Evidence)
Entrez Gene20980 (Evidence)
UniGene5102
DFCITC1587594, TC1587914, TC1647342, TC1669655
DoTSDT.101347413, DT.55164625, DT.99823174
NIA Mouse Gene IndexU000833
PDB4KBB, 2NP0
Consensus CDS ProjectCCDS15312.1
International Mouse Knockout Project StatusSyt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029462 VEGA Gene Model | MGI Sequence Detail 115917 C57BL/6J ±  kb
transcript OTTMUST00000126827 VEGA | MGI Sequence Detail 3386 Not Applicable 
polypeptide OTTMUSP00000068564 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(8) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(1646 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR001565 Synaptotagmin
Protein Ontology PR:000015904 synaptotagmin-2
References (Earliest) J:1973 Willison K, The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990 Apr;6(4):104-5
(Latest) J:207796 Choi HY, et al., APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
All references(68)
Other
accession IDs
MGD-MRK-16451, MGI:2138727

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory