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Drd1a
Gene Detail
 Symbol
Name
ID
Drd1a
dopamine receptor D1A
MGI:99578
Synonyms C030036C15Rik, D1 receptor, Drd1, Drd-1, Gpcr15
Feature Type protein coding gene
Genetic Map
Chromosome 13
28.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr13:54051186-54055658 bp, - strand
From Ensembl annotation of GRCm38

  4473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: D1-like dopamine receptor
Gene Tree: Drd1a

Human
homologs
Human Homolog DRD1, dopamine receptor D1
NCBI Gene ID 1812
neXtProt AC  NX_P21728
Human Synonyms  DADR, DRD1A
Human Chr (Location)  5q35.1; chr5:175440672-175444160 (-)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Targeted(9)
 
Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity.
 
Human Diseases Modeled Using Mouse Drd1a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (151 annotations)
Process activation of adenylate cyclase activity, adenylate cyclase-activating dopamine receptor signaling pathway, ...
Component axon, axon terminus, ...
Function angiotensin receptor binding, ATPase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (228)    Tissues (159)    Images (30)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 133
RT-PCR 95
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(8) Primer pair(3) Other(6)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021478 (Evidence)
Entrez Gene13488 (Evidence)
DFCITC1585198, TC1613462
DoTSDT.91397785
NIA Mouse Gene IndexU034791
Consensus CDS ProjectCCDS26524.1
International Mouse Knockout Project StatusDrd1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021478 Ensembl Gene Model | MGI Sequence Detail 4473 C57BL/6J ±  kb
transcript ENSMUST00000021932 Ensembl | MGI Sequence Detail 3526 Not Applicable 
polypeptide ENSMUSP00000021932 Ensembl | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001413 Dopamine D1 receptor
InterPro IPR000497 Dopamine D5 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001175 D(1A) dopamine receptor
References (Earliest) J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
(Latest) J:206008 Smardencas A, et al., Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases. BMC Neurosci. 2013;14:111
All references(192)
Other
accession IDs
MGD-MRK-16360, MGD-MRK-16387, MGD-MRK-8892, MGD-MRK-8896, MGI:1924787

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory