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Drd1 Gene Detail
Summary
  • Symbol
    Drd1
  • Name
    dopamine receptor D1
  • Synonyms
    C030036C15Rik, D1 receptor, Drd-1, Drd1a, Gpcr15
  • Feature Type
    protein coding gene
  • IDs
    MGI:99578
    NCBI Gene: 13488
  • Gene Overview
    MyGene.info: DRD1
Location & Maps
more
  • Sequence Map
    Chr13:54051186-54055658 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 28.40 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    DRD1, dopamine receptor D1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DRD1, dopamine receptor D1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DADR, DRD1A
  • Links
    NCBI Gene ID: 1812
    neXtProt AC: NX_P21728

  • Chr Location
    5q35.2; chr5:175440672-175444160 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Drd1 mouse models

Human Disease Mouse Models
       Huntington Disease; HD   OMIM: 143100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    67 phenotypes from 10 alleles in 17 genetic backgrounds
    37 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Targeted
    12
  • Genomic Mutations
    1 involving Drd1
  • Incidental Mutations
Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021478 Ensembl Gene Model | MGI Sequence Detail 4473 C57BL/6J ±  kb
transcript ENSMUST00000021932 Ensembl | MGI Sequence Detail 3526 Not Applicable  
polypeptide ENSMUSP00000021932 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 8
    Primer pair 3
    Other 6

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16360, MGD-MRK-16387, MGD-MRK-8892, MGD-MRK-8896, MGI:1924787
References
more
  • Summaries
    All 209
    Developmental Gene Expression 18
    Diseases 1
    Gene Ontology 70
    Phenotypes 104
  • Earliest
    J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
  • Latest
    J:235288 Wang C, et al., VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiol Aging. 2016 Oct;46:22-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory