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Drd1
Gene Detail
Symbol

Name
ID
Drd1
dopamine receptor D1
MGI:99578
Synonyms
C030036C15Rik, D1 receptor, Drd-1, Drd1a, Gpcr15
Feature Type
protein coding gene
Genetic Map
Chromosome 13
28.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr13:54051186-54055658 bp, - strand
From Ensembl annotation of GRCm38

  4473 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:30992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DRD1
Protein SuperFamily: D1-like dopamine receptor
Gene Tree: Drd1

Human
homologs
DRD1, dopamine receptor D1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1812
neXtProt AC: NX_P21728

Human Synonyms: DADR, DRD1A

Human Chr (Location): 5q35.1; chr5:175440672-175444160 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity.
 
Human Diseases Modeled in Mice Using Drd1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Drd1 interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (228)    Tissues (159)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 133
RT-PCR 95
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase drd1 ; ZFIN drd1b    NEW 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(8) Primer pair(3) Other(6)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021478 (Evidence)
Entrez Gene 13488 (Evidence)
DFCI TC1585198, TC1613462
DoTS DT.101365166, DT.91397785
NIA Mouse Gene Index U034791
Consensus CDS Project CCDS26524.1
International Mouse Phenotyping Consortium Status Drd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021478 Ensembl Gene Model | MGI Sequence Detail 4473 C57BL/6J ±  kb
transcript ENSMUST00000021932 Ensembl | MGI Sequence Detail 3526 Not Applicable 
polypeptide ENSMUSP00000021932 Ensembl | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001413 Dopamine D1 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001175 D(1A) dopamine receptor
References
(Earliest) J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(205)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16360, MGD-MRK-16387, MGD-MRK-8892, MGD-MRK-8896, MGI:1924787

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory