Drd1a
Gene Detail

Symbol Name ID

Drd1a dopamine receptor D1A MGI:99578

Synonyms

C030036C15Rik, D1 receptor, Drd1, Drd-1, Gpcr15

Feature Type

protein coding gene

Genetic Map

Chromosome 13

28.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr13:54051186-54055658 bp, - strand From Ensembl annotation of GRCm38   4473 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: D1-like dopamine receptor
Gene Tree: Drd1a

Human homologs

Human Homolog		DRD1, dopamine receptor D1
NCBI Gene ID		1812
neXtProt AC		NX_P21728
Human Synonyms		DADR, DRD1A
Human Chr (Location)		5q35.1; chr5:174867675-174871163 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity.

 
Human Diseases Modeled Using Mouse Drd1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (138 annotations)

Process	activation of adenylate cyclase activity, adenylate cyclase-activating dopamine receptor signaling pathway, ...
Component	axon, caveola, ...
Function	dopamine binding, dopamine neurotransmitter receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (228)    Tissues (159)    Images (30)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	133
RT-PCR	95

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(8) Primer pair(3) Other(6)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021478 (Evidence)
Entrez Gene	13488 (Evidence)
DFCI	TC1585198, TC1613462
DoTS	DT.91397785
NIA Mouse Gene Index	U034791
Consensus CDS Project	CCDS26524.1
International Mouse Knockout Project Status	Drd1a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021478	Ensembl Gene Model | MGI Sequence Detail	4473	C57BL/6J
transcript	ENSMUST00000021932	Ensembl | MGI Sequence Detail	3526	Not Applicable
polypeptide	ENSMUSP00000021932	Ensembl | MGI Sequence Detail	446	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001413	Dopamine 1A receptor
InterPro	IPR000929	Dopamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001175	D(1A) dopamine receptor

References

(Earliest) J:1700 Johnson KR, et al., A multipoint genetic linkage map of mouse chromosome 18. Genomics. 1992 Aug;13(4):1143-9
(Latest) J:193442 Xing B, et al., The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice. Behav Brain Res. 2012 Nov 1;235(1):36-41
All references(185)

Other accession IDs

MGD-MRK-16360, MGD-MRK-16387, MGD-MRK-8892, MGD-MRK-8896, MGI:1924787