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Tal2
Gene Detail
Symbol

Name
ID
Tal2
T cell acute lymphocytic leukemia 2
MGI:99540
Synonyms
bHLHa19
Feature Type
protein coding gene
Genetic Map
Chromosome 4
28.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:53779705-53788712 bp, + strand
From VEGA annotation of GRCm38

  9008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: TAL2
Gene Tree: Tal2

Human
homologs
TAL2, T-cell acute lymphocytic leukemia 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6887
neXtProt AC: NX_Q16559

Human Chr (Location): 9q32; chr9:105662457-105663112 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygous mutation of this gene results in growth retardation and lethality before reaching reproductive age. Mice exhibit brain abnormalities including a small superior colliculus and progressive hydrocephalus.
 
Interactions
Tal2 interacts with 249 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process midbrain development, multicellular organism growth, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (125)    Tissues (102)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TAL2 ; Xenbase LOC100491656 ; ZFIN tal2    NEW 
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000007003 (Evidence)
Ensembl Gene Model ENSMUSG00000028417 (Evidence)
Entrez Gene 21350 (Evidence)
DFCI TC1591238, TC1667515
DoTS DT.91336130
Consensus CDS Project CCDS18192.1
International Mouse Phenotyping Consortium Status Tal2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007003 VEGA Gene Model | MGI Sequence Detail 9008 C57BL/6J ±  kb
transcript OTTMUST00000016194 VEGA | MGI Sequence Detail 2971 Not Applicable 
polypeptide OTTMUSP00000007421 VEGA | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016044 T-cell acute lymphocytic leukemia protein 2
References
(Earliest) J:19155 Xia Y, et al., TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20
(Latest) J:218837 Song H, et al., Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015 Feb 15;398(2):280-91
All references(40)
Other
accession IDs
MGD-MRK-16318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory