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Tal2
Gene Detail
Symbol

Name
ID
Tal2
T cell acute lymphocytic leukemia 2
MGI:99540
Synonyms
bHLHa19
Feature Type
protein coding gene
Genetic Map
Chromosome 4
28.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:53779705-53788712 bp, + strand
From VEGA annotation of GRCm38

  9008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tal2

Human
homologs
Human Homolog TAL2, T-cell acute lymphocytic leukemia 2
NCBI Gene ID 6887
neXtProt AC  NX_Q16559
Human Chr (Location)  9q32; chr9:105662457-105663112 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Homozygous mutation of this gene results in growth retardation and lethality before reaching reproductive age. Mice exhibit brain abnormalities including a small superior colliculus and progressive hydrocephalus.
 
Interactions
Tal2 interacts with 249 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process midbrain development, multicellular organism growth, ...
Function DNA binding, protein dimerization activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (125)    Tissues (102)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 125
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000007003 (Evidence)
Ensembl Gene ModelENSMUSG00000028417 (Evidence)
Entrez Gene21350 (Evidence)
DFCITC1591238, TC1667515
DoTSDT.91336130
Consensus CDS ProjectCCDS18192.1
International Mouse Knockout Project StatusTal2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007003 VEGA Gene Model | MGI Sequence Detail 9008 C57BL/6J ±  kb
transcript OTTMUST00000016194 VEGA | MGI Sequence Detail 2971 Not Applicable 
polypeptide OTTMUSP00000007421 VEGA | MGI Sequence Detail 108 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016044 T-cell acute lymphocytic leukemia protein 2
References
(Earliest) J:19155 Xia Y, et al., TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20
(Latest) J:203421 Achim K, et al., The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors. Biol Open. 2013;2(10):990-7
All references(39)
Other
accession IDs
MGD-MRK-16318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory