Tal2
Gene Detail

Symbol Name ID

Tal2 T cell acute lymphocytic leukemia 2 MGI:99540

Synonyms

bHLHa19

Feature Type

protein coding gene

Genetic Map

Chromosome 4

28.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:53779705-53788712 bp, + strand From VEGA annotation of GRCm38   9008 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tal2

Human homologs

Human Homolog		TAL2, T-cell acute lymphocytic leukemia 2
NCBI Gene ID		6887
neXtProt AC		NX_Q16559
Human Chr (Location)		9q32; chr9:108424738-108425393 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous mutation of this gene results in growth retardation and lethality before reaching reproductive age. Mice exhibit brain abnormalities including a small superior colliculus and progressive hydrocephalus.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	midbrain development, multicellular organism growth, ...
Function	DNA binding, protein dimerization activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (76)    Tissues (53)    Images (16)
Theiler Stages: 15, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	76

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000007003 (Evidence)
Ensembl Gene Model	ENSMUSG00000028417 (Evidence)
Entrez Gene	21350 (Evidence)
DFCI	TC1591238, TC1667515
DoTS	DT.91336130
Consensus CDS Project	CCDS18192.1
International Mouse Knockout Project Status	Tal2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007003	VEGA Gene Model | MGI Sequence Detail	9008	C57BL/6J
transcript	OTTMUST00000016194	VEGA | MGI Sequence Detail	2971	Not Applicable
polypeptide	OTTMUSP00000007421	VEGA | MGI Sequence Detail	108	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000016044	T-cell acute lymphocytic leukemia protein 2

References

(Earliest) J:19155 Xia Y, et al., TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11416-20
(Latest) J:188110 Virolainen SM, et al., Transcriptional regulatory mechanisms underlying the GABAergic neuron fate in different diencephalic prosomeres. Development. 2012 Oct;139(20):3795-805
All references(38)

Other accession IDs

MGD-MRK-16318