About   Help   FAQ
Prdx1 Gene Detail
Summary
  • Symbol
    Prdx1
  • Name
    peroxiredoxin 1
  • Synonyms
    macrophage 23kDa stress protein, macrophase stress protein 22kDa, MSP23, OSF-3, osteoblast specific factor 3, PAG, Paga, prx1, PrxI, Prx I, Tdpx2, TDX2, thioredoxin dependent peroxide reductase 2, Trx dependent peroxide reductase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99523
    NCBI Gene: 18477
  • Gene Overview
    MyGene.info: PRDX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:116685544-116700822 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15279 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRDX1, peroxiredoxin 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PRDX1, peroxiredoxin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MSP23, NKEFA, NKEF-A, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2
  • Links
    NCBI Gene ID: 5052
    neXtProt AC: NX_Q06830
    UniProt: Q06830

  • Chr Location
    1p34.1; chr1:45511035-45522890 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 99789
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PRDX1
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PRDX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 3 alleles in 3 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009533 VEGA Gene Model | MGI Sequence Detail 15279 C57BL/6J ±  kb
    transcript OTTMUST00000021824 VEGA | MGI Sequence Detail 877 Not Applicable  
    polypeptide OTTMUSP00000009957 VEGA | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      175 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 23
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16300
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 10
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:14699 Ishii T, et al., Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem. 1993 Sep 5;268(25):18633-6
    • Latest
      J:248365 Kang DH, et al., Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. Nat Commun. 2017 Jun 28;8(1):40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory