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Prdx1
Gene Detail
 Symbol
Name
ID
Prdx1
peroxiredoxin 1
MGI:99523
Synonyms macrophage 23kDa stress protein, macrophase stress protein 22kDa, MSP23, OSF-3, osteoblast specific factor 3, PAG, Paga, prx1, PrxI, Prx I, Tdpx2, TDX2, thioredoxin dependent peroxide reductase 2, Trx dependent peroxide reductase 2
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:116685544-116700822 bp, + strand
From VEGA annotation of GRCm38

  15279 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99789  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: AHPC
Gene Tree: Prdx1

Human
homologs
Human Homolog PRDX1, peroxiredoxin 1
NCBI Gene ID 5052
neXtProt AC  NX_Q06830
Human Synonyms  MSP23, NKEFA, NKEF-A, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2
Human Chr (Location)  1p34.1; chr1:45511035-45522890 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(123) : Gene trapped(118) Spontaneous(1) Targeted(4)
 
Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice which die prematurely.
 
Interactions
Prdx1 interacts with 176 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell proliferation, erythrocyte homeostasis, ...
Component cytoplasm, cytosol, ...
Function antioxidant activity, heme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (161)    Tissues (146)    Images (25)
Theiler Stages: 11, 13, 15, 17, 20, 21, 22, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 129
Northern blot 14
Western blot 2
RT-PCR 14
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(22) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009533 (Evidence)
Ensembl Gene ModelENSMUSG00000028691 (Evidence)
Entrez Gene18477 (Evidence)
DFCITC1573725
DoTSDT.102542465, DT.55107834, DT.94144523, DT.94144554, DT.97366048
EC1.11.1.15
Consensus CDS ProjectCCDS18515.1
International Mouse Knockout Project StatusPrdx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009533 VEGA Gene Model | MGI Sequence Detail 15279 C57BL/6J ±  kb
transcript OTTMUST00000021824 VEGA | MGI Sequence Detail 877 Not Applicable 
polypeptide OTTMUSP00000009957 VEGA | MGI Sequence Detail 199 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
InterPro IPR024706 Peroxiredoxin, AhpC-type
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000013191 peroxiredoxin-1
References (Earliest) J:14699 Ishii T, et al., Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem. 1993 Sep 5;268(25):18633-6
(Latest) J:191045 Huebner AJ, et al., Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell. 2012 Dec 11;23(6):1238-46
All references(67)
Other
accession IDs
MGD-MRK-16300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory