About   Help   FAQ
Hspa1b Gene Detail
Summary
  • Symbol
    Hspa1b
  • Name
    heat shock protein 1B
  • Synonyms
    hsp68, Hsp70-1, Hsp70.1, HSP70B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99517
    NCBI Gene: 15511
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34956436-34959238 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.50 cM
  • Mapping Data
    18 experiments
  • Sequence Tags
Strain
Comparison
more
  • Strain Annotations
    16
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99517
protein coding gene Chr17:34956429-34959238 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023600
protein coding gene Chr17:35080221-35101886 (-)
A/J MGP_AJ_G0023562
protein coding gene Chr17:33930431-33946172 (-)
AKR/J MGP_AKRJ_G0023528
protein coding gene Chr17:34393582-34396380 (-)
BALB/cJ MGP_BALBcJ_G0023568
protein coding gene Chr17:34050973-34053089 (-)
C3H/HeJ MGP_C3HHeJ_G0023327
protein coding gene Chr17:34791590-34795810 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024007
protein coding gene Chr17:36417181-36433579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021486
protein coding gene Chr17:31698032-31700884 (-)
CAST/EiJ MGP_CASTEiJ_G0022826
protein coding gene Chr17:34806468-34812304 (-)
CBA/J MGP_CBAJ_G0023306
protein coding gene Chr17:37926843-37929645 (-)
DBA/2J MGP_DBA2J_G0023436
protein coding gene Chr17:33267834-33271389 (+)
FVB/NJ MGP_FVBNJ_G0023400
protein coding gene Chr17:33080939-33084223 (-)
LP/J MGP_LPJ_G0023510
protein coding gene Chr17:35420214-35427511 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0024051
protein coding gene Chr17:34618092-34621378 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0022391
protein coding gene Chr17:32623098-32625809 (-)
WSB/EiJ MGP_WSBEiJ_G0022888
protein coding gene Chr17:34746475-34750549 (-)



Homology
more
  • Human Ortholog
    HSPA1B, heat shock protein family A (Hsp70) member 1B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HSPA1B, heat shock protein family A (Hsp70) member 1B
    Orthology source: HGNC
  • Synonyms
    HSP70-1, HSP70.1, HSP70-1B, HSP70-2, HSP70.2, HSP72, HSPA1, HSX70
  • Links
    NCBI Gene ID: 3304
    neXtProt AC: NX_P0DMV8, NX_P0DMV9
    UniProt: P0DMV9

  • Chr Location
    6p21.33; chr6:31827735-31830254 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased susceptibility to focal cerebral ischemic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000090877 Ensembl Gene Model | MGI Sequence Detail 2803 C57BL/6J ±  kb
    transcript ENSMUST00000172753 Ensembl | MGI Sequence Detail 2803 Not Applicable  
    polypeptide ENSMUSP00000133815 Ensembl | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 17
      cDNA 10
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10958, MGD-MRK-16294
    References
    more
    • Summaries
      All 213
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 42
    • Earliest
      J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
    • Latest
      J:271839 You Z, et al., KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons. Exp Neurol. 2019 Mar;313:88-97

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory