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Hspa1b Gene Detail
Summary
  • Symbol
    Hspa1b
  • Name
    heat shock protein 1B
  • Synonyms
    hsp68, Hsp70-1, Hsp70.1, HSP70A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99517
    NCBI Gene: 15511
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34956436-34959238 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2803 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.50 cM
  • Mapping Data
    18 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    HSPA1B, heat shock protein family A (Hsp70) member 1B
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HSPA1B, heat shock protein family A (Hsp70) member 1B
    Orthology source: HGNC
  • Synonyms
    HSP70-1B, HSP70-2, HSP70.2
  • Links
    NCBI Gene ID: 3304
    neXtProt AC: NX_P0DMV8, NX_P0DMV9
    UniProt: P0DMV9

  • Chr Location
    6p21.33; chr6:31827735-31830254 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased susceptibility to focal cerebral ischemic injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037920 VEGA Gene Model | MGI Sequence Detail 2803 C57BL/6J ±  kb
    transcript OTTMUST00000097740 VEGA | MGI Sequence Detail 2803 Not Applicable  
    polypeptide OTTMUSP00000054815 VEGA | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 17
      cDNA 9
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10958, MGD-MRK-16294
    References
    more
    • Summaries
      All 208
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 39
    • Earliest
      J:7195 Lowe DG, et al., Mouse and Drosophila genes encoding the major heat shock protein (hsp70) are highly conserved. Mol Cell Biol. 1983 Aug;3(8):1540-3
    • Latest
      J:253495 Zhang G, et al., Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. Nat Commun. 2017 Sep 19;8(1):589

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory