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Syk
Gene Detail
Symbol

Name
ID
Syk
spleen tyrosine kinase
MGI:99515
Synonyms
Sykb
Feature Type
protein coding gene
Genetic Map
Chromosome 13
27.41 cM, cytoband B-C2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:52583173-52648792 bp, + strand
From VEGA annotation of GRCm38

  65620 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYK
Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree: Syk

Human
homologs
SYK, spleen tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6850
neXtProt AC: NX_P43405

Human Synonyms: p72-Syk

Human Chr (Location): 9q22; chr9:90801680-90898560 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.
 
Interactions
Syk interacts with 276 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process activation of JUN kinase activity, activation of MAPK activity, ...
Component B cell receptor complex, cell, ...
Function ATP binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (12)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 12
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase syk ; ZFIN syk    NEW 
Molecular
reagents
All nucleic(45) Genomic(1) cDNA(44)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000031741 (Evidence)
Ensembl Gene Model ENSMUSG00000021457 (Evidence)
Entrez Gene 20963 (Evidence)
UniGene 375031
DFCI TC1588265, TC1672324
DoTS DT.101360528, DT.110965587, DT.489120, DT.55200718, DT.91340731, DT.94124209
NIA Mouse Gene Index U014851
EC 2.7.10.2
PDB 2LCT, 2MC1
Consensus CDS Project CCDS26517.1
International Mouse Phenotyping Consortium Status Syk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031741 VEGA Gene Model | MGI Sequence Detail 65620 C57BL/6J ±  kb
transcript OTTMUST00000078613 VEGA | MGI Sequence Detail 5363 Not Applicable 
polypeptide OTTMUSP00000041830 VEGA | MGI Sequence Detail 629 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(461 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
InterPro IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Protein Ontology PR:000003065 tyrosine-protein kinase SYK
References
(Earliest) J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
(Latest) J:222314 Konigsberger S, et al., Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms. Eur J Immunol. 2015 Feb;45(2):603-11
All references(192)
Other
accession IDs
MGD-MRK-16292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory