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Syk Gene Detail
Summary
  • Symbol
    Syk
  • Name
    spleen tyrosine kinase
  • Synonyms
    Sykb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99515
    NCBI Gene: 20963
  • Gene Overview
    MyGene.info: SYK
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:52583173-52648792 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      65620 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.41 cM, cytoband B-C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p72-Syk
  • Links
    NCBI Gene ID: 6850
    neXtProt AC: NX_P43405
    UniProt: P43405

  • Chr Location
    9q22.2; chr9:90801680-90898560 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 7 alleles in 15 genetic backgrounds
    83 phenotypes from multigenic genotypes
    3 images
    133 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    12
  • Tissues
    2
  • cDNA Data
    45
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031741 VEGA Gene Model | MGI Sequence Detail 65620 C57BL/6J ±  kb
    transcript OTTMUST00000078613 VEGA | MGI Sequence Detail 5363 Not Applicable  
    polypeptide OTTMUSP00000041830 VEGA | MGI Sequence Detail 629 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      461 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 45

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16292
    References
    more
    • Summaries
      All 259
      Developmental Gene Expression 13
      Gene Ontology 41
      Phenotypes 133
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:255660 Leonardi I, et al., CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi. Science. 2018 Jan 12;359(6372):232-236
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory