Syk Gene Detail

Summary

• Symbol
  Syk
• Name
  spleen tyrosine kinase
• Synonyms
  Sykb

• Feature Type
  protein coding gene
• IDs
  MGI:99515
  NCBI Gene: 20963
• Alliance
  gene page
• Transcription Start Sites
  51 TSS

Location &
Maps

• Sequence Map
  Chr13:52737209-52802828 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 27.41 cM, cytoband B-C2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  461 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99515	protein coding gene	Chr13:52736670-52802828 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020557	protein coding gene	Chr13:51860224-51926418 (+)
A/J	MGP_AJ_G0020511	protein coding gene	Chr13:50007689-50073259 (+)
AKR/J	MGP_AKRJ_G0020489	protein coding gene	Chr13:51431351-51497129 (+)
BALB/cJ	MGP_BALBcJ_G0020507	protein coding gene	Chr13:50204940-50273032 (+)
C3H/HeJ	MGP_C3HHeJ_G0020306	protein coding gene	Chr13:51269363-51340278 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020941	protein coding gene	Chr13:53464132-53530884 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018523	protein coding gene	Chr13:47789420-47854407 (+)
CAST/EiJ	MGP_CASTEiJ_G0019820	protein coding gene	Chr13:51265553-51374473 (+)
CBA/J	MGP_CBAJ_G0020266	protein coding gene	Chr13:55470688-55539022 (+)
DBA/2J	MGP_DBA2J_G0020389	protein coding gene	Chr13:49571609-49636692 (+)
FVB/NJ	MGP_FVBNJ_G0020368	protein coding gene	Chr13:49014644-49080898 (+)
LP/J	MGP_LPJ_G0020465	protein coding gene	Chr13:52136606-52206618 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020397	protein coding gene	Chr13:55071601-55151747 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020984	protein coding gene	Chr13:51023842-51093637 (+)
PWK/PhJ	MGP_PWKPhJ_G0019576	protein coding gene	Chr13:49509135-49613244 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019403	protein coding gene	Chr13:49868410-50019541 (+)
WSB/EiJ	MGP_WSBEiJ_G0019882	protein coding gene	Chr13:51348269-51414347 (+)

Homology

• Human Ortholog
  SYK, spleen associated tyrosine kinase

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SYK, spleen associated tyrosine kinase
  
• Synonyms
  IMD82, p72-Syk
• Links
  HGNC:11491

  NCBI Gene ID: 6850

  neXtProt AC: NX_P43405

  UniProt: P43405

  
  
• Chr Location
  9q22.2; chr9:90801600-90898549 (+)  GRCh38

---

• MGI Vertebrate Homology
  Syk stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: SYK
• Protein SuperFamily
  TyrPK_SYK
• Gene Tree
  Syk
  

Human Diseases

• Diseases
  1 with human SYK associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease       DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  53 phenotypes from 8 alleles in 16 genetic backgrounds
  41 phenotypes from multigenic genotypes
  171 phenotype references
  

• All Mutations and Alleles
  28
• Chemically induced (ENU)
  2
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  6
• Targeted
  16
• Genomic Mutations
  1 involving Syk
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  42 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  178
• GO References
  47

Expression

• Assay Results
  718
• Tissues
  2
• cDNA Data
  45
• Literature Summary
  16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase syk
  ZFIN syk

Sequences &
Gene Models

• All Sequences
  58
• RefSeq
  12
• UniProt
  5
• CCDS
  CCDS26517.1

• Ensembl
  ENSMUSG00000021457 (Evidence)
• NCBI Gene
  20963

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000021457	Ensembl Gene Model | MGI Sequence Detail	65620	C57BL/6J
transcript	ENSMUST00000055087	Ensembl | MGI Sequence Detail	5122	Not Applicable
polypeptide	ENSMUSP00000060828	Ensembl | MGI Sequence Detail	629	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• Protein Ontology
  PR:000003065 tyrosine-protein kinase SYK
  (term hierarchy)
• PDB
  2LCT, 2MC1
• EC
  2.7.10.2
• InterPro Domains
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
  IPR000980 SH2 domain
  IPR036860 SH2 domain superfamily
  IPR035838 SYK/ZAP-70, N-terminal SH2 domain
  IPR008266 Tyrosine-protein kinase, active site
  IPR020635 Tyrosine-protein kinase, catalytic domain
  IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
  IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

Molecular
Reagents

• All nucleic 46

  Genomic 1

  cDNA 45

  
  

  Microarray probesets 7

Other
Accession IDs

MGD-MRK-16292

References

• Summaries
  All 315

  Developmental Gene Expression 16

  Gene Ontology 47

  Phenotypes 171
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:346941 Rohila D, et al., Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma. Front Immunol. 2023;14:1148317

TSS for Syk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119776	Chr13:52736600-52736632 (+)	-593 bp
Tssr119777	Chr13:52736695-52736713 (+)	-505 bp
Tssr119778	Chr13:52736730-52736741 (+)	-473 bp
Tssr119779	Chr13:52736757-52736771 (+)	-445 bp
Tssr119780	Chr13:52736776-52736795 (+)	-423 bp
Tssr119781	Chr13:52736801-52736816 (+)	-400 bp
Tssr119782	Chr13:52736828-52736840 (+)	-375 bp
Tssr119783	Chr13:52736848-52736855 (+)	-357 bp
Tssr119784	Chr13:52737074-52737097 (+)	-123 bp
Tssr119785	Chr13:52737100-52737113 (+)	-102 bp
Tssr119786	Chr13:52737118-52737159 (+)	-70 bp
Tssr119787	Chr13:52737160-52737217 (+)	-20 bp
Tssr119788	Chr13:52737286-52737298 (+)	83 bp
Tssr119789	Chr13:52737337-52737348 (+)	134 bp
Tssr119790	Chr13:52737368-52737387 (+)	169 bp
Tssr119791	Chr13:52737424-52737436 (+)	221 bp
Tssr119792	Chr13:52737474-52737485 (+)	271 bp
Tssr119793	Chr13:52737488-52737510 (+)	290 bp
Tssr119794	Chr13:52737545-52737594 (+)	361 bp
Tssr119795	Chr13:52739269-52739305 (+)	2,078 bp
Tssr119796	Chr13:52739985-52739999 (+)	2,783 bp
Tssr119797	Chr13:52742233-52742245 (+)	5,030 bp
Tssr119798	Chr13:52745868-52745872 (+)	8,661 bp
Tssr119799	Chr13:52750883-52750894 (+)	13,680 bp
Tssr119800	Chr13:52750897-52750947 (+)	13,713 bp
Tssr119801	Chr13:52750956-52750975 (+)	13,757 bp
Tssr119802	Chr13:52750990-52751001 (+)	13,787 bp
Tssr119803	Chr13:52760950-52760969 (+)	23,751 bp
Tssr119804	Chr13:52761251-52761269 (+)	24,051 bp
Tssr119805	Chr13:52761304-52761327 (+)	24,107 bp
Tssr119806	Chr13:52763394-52763409 (+)	26,193 bp
Tssr119807	Chr13:52764759-52764770 (+)	27,556 bp
Tssr119808	Chr13:52764933-52764952 (+)	27,734 bp
Tssr119809	Chr13:52764966-52764993 (+)	27,771 bp
Tssr119810	Chr13:52771411-52771421 (+)	34,207 bp
Tssr119811	Chr13:52771432-52771439 (+)	34,227 bp
Tssr119812	Chr13:52772228-52772244 (+)	35,027 bp
Tssr119813	Chr13:52772699-52772718 (+)	35,500 bp
Tssr119814	Chr13:52772747-52772792 (+)	35,561 bp
Tssr119815	Chr13:52774971-52774983 (+)	37,768 bp
Tssr119816	Chr13:52784073-52784090 (+)	46,873 bp
Tssr119817	Chr13:52786993-52787022 (+)	49,799 bp
Tssr119818	Chr13:52787363-52787373 (+)	50,159 bp
Tssr119819	Chr13:52788315-52788333 (+)	51,115 bp
Tssr119820	Chr13:52789995-52790006 (+)	52,792 bp
Tssr119821	Chr13:52791187-52791197 (+)	53,983 bp
Tssr119822	Chr13:52795184-52795192 (+)	57,979 bp
Tssr119823	Chr13:52800570-52800583 (+)	63,368 bp
Tssr119824	Chr13:52800955-52800986 (+)	63,762 bp
Tssr119825	Chr13:52801043-52801054 (+)	63,840 bp
Tssr119826	Chr13:52802144-52802164 (+)	64,945 bp