Syk
Gene Detail

Symbol

Name
ID

Syk
spleen tyrosine kinase
MGI:99515

Synonyms

Sykb

Feature Type

protein coding gene

Genetic Map

Chromosome 13
27.41 cM, cytoband B-C2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:52583173-52648792 bp, + strand From VEGA annotation of GRCm38   65620 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree: Syk

Human
homologs

Human Homolog		SYK, spleen tyrosine kinase
NCBI Gene ID		6850
neXtProt AC		NX_P43405
Human Synonyms		p72-Syk
Human Chr (Location)		9q22; chr9:90801730-90898560 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(15)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.

 

Interactions

Syk interacts with 277 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (103 annotations)

Process	activation of JUN kinase activity, activation of MAPK activity, ...
Component	B cell receptor complex, cell, ...
Function	ATP binding, integrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (12)    Tissues (2)    Images (2)    Tissue x Stage Matrix (view)

Assay Type	Results
Western blot	12

cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(45) Genomic(1) cDNA(44)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000031741 (Evidence)
Ensembl Gene Model	ENSMUSG00000021457 (Evidence)
Entrez Gene	20963 (Evidence)
UniGene	375031
DFCI	TC1588265, TC1672324
DoTS	DT.101360528, DT.110965587, DT.489120, DT.55200718, DT.91340731, DT.94124209
NIA Mouse Gene Index	U014851
EC	2.7.10.2
PDB	2LCT, 2MC1
Consensus CDS Project	CCDS26517.1
International Mouse Knockout Project Status	Syk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031741	VEGA Gene Model | MGI Sequence Detail	65620	C57BL/6J
transcript	OTTMUST00000078613	VEGA | MGI Sequence Detail	5363	Not Applicable
polypeptide	OTTMUSP00000041830	VEGA | MGI Sequence Detail	629	Not Applicable

All sequences(55) RefSeq(10) UniProt(5)

Polymorphisms

SNPs within 2kb(461 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70
InterPro	IPR023420	Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain
Protein Ontology	PR:000003065	tyrosine-protein kinase SYK

References

(Earliest) J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
(Latest) J:217519 Hobeika E, et al., CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015 Jan 28;
All references(193)

Other
accession IDs

MGD-MRK-16292