Syk MGI Mouse Gene Detail - MGI:99515 - spleen tyrosine kinase

Symbol

Syk
Name

spleen tyrosine kinase
Synonyms

Sykb

Feature Type

protein coding gene
IDs

MGI:99515
NCBI Gene: 20963
Gene Overview

MyGene.info: SYK
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr13:52583173-52648792 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 27.41 cM, cytoband B-C2
Mapping Data

2 experiments

SNPs within 2kb

461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99515	protein coding gene	Chr13:52582610-52648792 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020557	protein coding gene	Chr13:51860224-51926418 (+)
A/J	MGP_AJ_G0020511	protein coding gene	Chr13:50007689-50073259 (+)
AKR/J	MGP_AKRJ_G0020489	protein coding gene	Chr13:51431351-51497129 (+)
BALB/cJ	MGP_BALBcJ_G0020507	protein coding gene	Chr13:50204940-50273032 (+)
C3H/HeJ	MGP_C3HHeJ_G0020306	protein coding gene	Chr13:51269363-51340278 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020941	protein coding gene	Chr13:53464132-53530884 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018523	protein coding gene	Chr13:47789420-47854407 (+)
CAST/EiJ	MGP_CASTEiJ_G0019820	protein coding gene	Chr13:51265553-51374473 (+)
CBA/J	MGP_CBAJ_G0020266	protein coding gene	Chr13:55470688-55539022 (+)
DBA/2J	MGP_DBA2J_G0020389	protein coding gene	Chr13:49571609-49636692 (+)
FVB/NJ	MGP_FVBNJ_G0020368	protein coding gene	Chr13:49014644-49080898 (+)
LP/J	MGP_LPJ_G0020465	protein coding gene	Chr13:52136606-52206618 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020397	protein coding gene	Chr13:55071601-55151747 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020984	protein coding gene	Chr13:51023842-51093637 (+)
PWK/PhJ	MGP_PWKPhJ_G0019576	protein coding gene	Chr13:49509135-49613244 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019403	protein coding gene	Chr13:49868410-50019541 (+)
WSB/EiJ	MGP_WSBEiJ_G0019882	protein coding gene	Chr13:51348269-51414347 (+)

Human Ortholog

SYK, spleen associated tyrosine kinase

Vertebrate Orthologs

10

Human Ortholog

SYK, spleen associated tyrosine kinase
Orthology source: HomoloGene, HGNC
Synonyms

p72-Syk
Links

HGNC:11491

NCBI Gene ID: 6850

neXtProt AC: NX_P43405

UniProt: P43405
Chr Location

9q22.2; chr9:90801680-90898560 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2390
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SYK
Protein SuperFamily

tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree

Syk

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Phenotype Summary

54 phenotypes from 8 alleles in 16 genetic backgrounds
83 phenotypes from multigenic genotypes
3 images
150 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (ENU)

2
Chemically induced (other)

1
Gene trapped

6
Targeted

17
Genomic Mutations

1 involving Syk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.

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All GO Annotations

137
GO References

41

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

2
cDNA Data

45
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syk

ZFIN syk

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Syk interacts with 276 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

58
RefSeq

12
UniProt

5
CCDS

CCDS26517.1
UniGene

375031

Ensembl

ENSMUSG00000021457 (Evidence)
NCBI Gene

20963

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021457	Ensembl Gene Model \| MGI Sequence Detail	65620	C57BL/6J	± kb
transcript	ENSMUST00000120135	Ensembl \| MGI Sequence Detail	5363	Not Applicable
polypeptide	ENSMUSP00000113852	Ensembl \| MGI Sequence Detail	629	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003065 tyrosine-protein kinase SYK

(term hierarchy)
PDB

2LCT, 2MC1
EC

2.7.10.2
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR035838 SYK/ZAP-70, N-terminal SH2 domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70

IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

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All nucleic 46

Genomic 1

cDNA 45

Microarray probesets 7

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MGD-MRK-16292

Summaries

All 275

Developmental Gene Expression 13

Gene Ontology 41

Phenotypes 150
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:286548 Dasari TK, et al., The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. J Biol Chem. 2020 Mar 13;295(11):3394-3400

TSS for Syk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119777	Chr13:52582659-52582677 (+)	-505 bp
Tssr119778	Chr13:52582694-52582705 (+)	-473 bp
Tssr119779	Chr13:52582721-52582735 (+)	-445 bp
Tssr119780	Chr13:52582740-52582759 (+)	-423 bp
Tssr119781	Chr13:52582765-52582780 (+)	-400 bp
Tssr119782	Chr13:52582792-52582804 (+)	-375 bp
Tssr119783	Chr13:52582812-52582819 (+)	-357 bp
Tssr119784	Chr13:52583038-52583061 (+)	-123 bp
Tssr119785	Chr13:52583064-52583077 (+)	-102 bp
Tssr119786	Chr13:52583082-52583123 (+)	-70 bp
Tssr119787	Chr13:52583124-52583181 (+)	-20 bp
Tssr119788	Chr13:52583250-52583262 (+)	83 bp
Tssr119789	Chr13:52583301-52583312 (+)	134 bp
Tssr119790	Chr13:52583332-52583351 (+)	169 bp
Tssr119791	Chr13:52583388-52583400 (+)	221 bp
Tssr119792	Chr13:52583438-52583449 (+)	271 bp
Tssr119793	Chr13:52583452-52583474 (+)	290 bp
Tssr119794	Chr13:52583509-52583558 (+)	361 bp
Tssr119799	Chr13:52596847-52596858 (+)	13,680 bp
Tssr119800	Chr13:52596861-52596911 (+)	13,713 bp
Tssr119801	Chr13:52596920-52596939 (+)	13,757 bp
Tssr119802	Chr13:52596954-52596965 (+)	13,787 bp
Tssr119807	Chr13:52610723-52610734 (+)	27,556 bp
Tssr119808	Chr13:52610897-52610916 (+)	27,734 bp
Tssr119809	Chr13:52610930-52610957 (+)	27,771 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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