Syk MGI Mouse Gene Detail - MGI:99515 - spleen tyrosine kinase

Syk Gene Detail

Symbol

Syk
Name

spleen tyrosine kinase
Synonyms

Sykb

Feature Type

protein coding gene
IDs

MGI:99515
NCBI Gene: 20963
Gene Overview

MyGene.info: SYK
Alliance

gene page

Sequence Map

Chr13:52583173-52648792 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

65620 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 27.41 cM, cytoband B-C2
Mapping Data

2 experiments

Human Ortholog

SYK, spleen associated tyrosine kinase

Vertebrate Orthologs

10

Human Ortholog

SYK, spleen associated tyrosine kinase
Orthology source: HomoloGene, HGNC
Synonyms

p72-Syk
Links

HGNC:11491

NCBI Gene ID: 6850

neXtProt AC: NX_P43405

UniProt: P43405
Chr Location

9q22.2; chr9:90801680-90898560 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2390
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SYK
Protein SuperFamily

tyrosine-protein kinase, SYK/ZAP-70 type
Gene Tree

Syk

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Phenotype Summary

48 phenotypes from 7 alleles in 15 genetic backgrounds
83 phenotypes from multigenic genotypes
3 images
121 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (ENU)

2
Chemically induced (other)

1
Gene trapped

6
Targeted

17
Genomic Mutations

1 involving Syk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.

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All GO Annotations

116
GO References

38

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

2
cDNA Data

44
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN syk

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Syk interacts with 276 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

51
RefSeq

14
UniProt

5
CCDS

CCDS26517.1
UniGene

375031

			Length	Strain/Species	Flank
genomic	OTTMUSG00000031741	VEGA Gene Model \| MGI Sequence Detail	65620	C57BL/6J	± kb
transcript	OTTMUST00000078613	VEGA \| MGI Sequence Detail	5363	Not Applicable
polypeptide	OTTMUSP00000041830	VEGA \| MGI Sequence Detail	629	Not Applicable

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SNPs within 2kb

461 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000003065 tyrosine-protein kinase SYK

(term hierarchy)
PDB

2LCT, 2MC1
EC

2.7.10.2
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR035838 SYK/ZAP-70, N-terminal SH2 domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70

IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

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All nucleic 45

Genomic 1

cDNA 44

Microarray probesets 7

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MGD-MRK-16292

Summaries

All 213

Developmental Gene Expression 11

Gene Ontology 38

Phenotypes 121
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:241854 Schweighoffer E, et al., TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017 May 01;214(5):1269-1280

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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