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Syk Gene Detail
Summary
  • Symbol
    Syk
  • Name
    spleen tyrosine kinase
  • Synonyms
    Sykb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99515
    NCBI Gene: 20963
  • Gene Overview
    MyGene.info: SYK
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:52583173-52648792 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      65620 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.41 cM, cytoband B-C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p72-Syk
  • Links
    NCBI Gene ID: 6850
    neXtProt AC: NX_P43405
    UniProt: P43405

  • Chr Location
    9q22.2; chr9:90801680-90898560 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 7 alleles in 15 genetic backgrounds
    83 phenotypes from multigenic genotypes
    3 images
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    118
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    12
  • Tissues
    2
  • cDNA Data
    44
  • Literature Summary
    12
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031741 VEGA Gene Model | MGI Sequence Detail 65620 C57BL/6J ±  kb
transcript OTTMUST00000078613 VEGA | MGI Sequence Detail 5363 Not Applicable  
polypeptide OTTMUSP00000041830 VEGA | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    461 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 44

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-16292
References
more
  • Summaries
    All 252
    Developmental Gene Expression 12
    Gene Ontology 40
    Phenotypes 129
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:254534 Gurung P, et al., Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1alpha-Mediated Inflammatory Disease. Immunity. 2017 Apr 18;46(4):635-648
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/03/2018
MGI 6.11 		The Jackson Laboratory