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Syk Gene Detail
Summary
  • Symbol
    Syk
  • Name
    spleen tyrosine kinase
  • Synonyms
    Sykb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99515
    NCBI Gene: 20963
  • Gene Overview
    MyGene.info: SYK
Location & Maps
more
  • Sequence Map
    Chr13:52583173-52648792 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65620 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SYK, spleen tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYK, spleen tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    p72-Syk
  • Links
    NCBI Gene ID: 6850
    neXtProt AC: NX_P43405

  • Chr Location
    9q22; chr9:90801680-90898560 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 6 alleles in 14 genetic backgrounds
    83 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    17
  • Genomic Mutations
    1 involving Syk
  • Incidental Mutations
Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031741 VEGA Gene Model | MGI Sequence Detail 65620 C57BL/6J ±  kb
transcript OTTMUST00000078613 VEGA | MGI Sequence Detail 5363 Not Applicable  
polypeptide OTTMUSP00000041830 VEGA | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    461 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 45
    Genomic 1
    cDNA 44

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-16292
References
more
  • Summaries
    All 197
    Developmental Gene Expression 10
    Gene Ontology 35
    Phenotypes 113
  • Earliest
    J:18037 Chan AC, et al., Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15;152(10):4758-66
  • Latest
    J:227729 Ryan J, et al., Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase. J Pathol. 2015 Aug 6;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory