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Dsg3 Gene Detail
Summary
  • Symbol
    Dsg3
  • Name
    desmoglein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99499
    NCBI Gene: 13512
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20643331-20674367 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.39 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1071 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99499
 protein coding gene Chr18:20643331-20680516 (+)
129S1/SvImJ ENSMUSG00200019634
 protein coding gene Chr18:17649655-17687487 (+)
A/J ENSMUSG00195002039
 protein coding gene Chr18:17794480-17831687 (+)
AKR/J ENSMUSG00220011324
 protein coding gene Chr18:17796324-17833497 (+)
BALB/cJ ENSMUSG00180003950
 protein coding gene Chr18:18255783-18292974 (+)
C3H/HeJ ENSMUSG00175004338
 protein coding gene Chr18:17742991-17780181 (+)
C57BL/6NJ ENSMUSG00215003486
 protein coding gene Chr18:17494884-17532075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022028
 protein coding gene Chr18:16747543-16777473 (+)
CAST/EiJ ENSTCUG00005014686
 protein coding gene Chr18:17534621-17573999 (+)
CBA/J ENSMUSG00210019951
 protein coding gene Chr18:17807561-17845389 (+)
DBA/2J ENSMUSG00185008062
 protein coding gene Chr18:17764797-17802642 (+)
FVB/NJ ENSMUSG00205015086
 protein coding gene Chr18:17502684-17540518 (+)
JF1/MsJ ENSUMUG00000022216
 protein coding gene Chr18:17815182-17852843 (+)
LP/J ENSMUSG00230010894
 protein coding gene Chr18:19845867-19883719 (+)
NOD/ShiLtJ ENSMUSG00190016831
 protein coding gene Chr18:17579548-17617376 (+)
NZO/HlLtJ ENSMUSG00225027745
 protein coding gene Chr18:19768558-19805752 (+)
PWK/PhJ ENSLUMG00010015314
 protein coding gene Chr18:17995273-18032322 (+)
SPRET/EiJ ENSMSPG00010004654
 protein coding gene Chr18:17910184-17947480 (+)
WSB/EiJ ENSIUOG00005019094
 protein coding gene Chr18:17606529-17643475 (+)



Homology
more
  • Human Ortholog
    DSG3, desmoglein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSG3, desmoglein 3
  • Synonyms
    ABOLM, CDHF6, PVA
  • Links
    NCBI Gene ID: 1830
    UniProt: P32926

  • Chr Location
    18q12.1; chr18:31447741-31478702 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dsg3 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 4 alleles in 4 genetic backgrounds
    6 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    660
  • Tissues
    45
  • cDNA Data
    15
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13512 NCBI Gene Model | MGI Sequence Detail 31037 C57BL/6J ±  kb
    transcript NM_030596 RefSeq | MGI Sequence Detail 4138 ZRU/MplStud  
    polypeptide O35902 UniProt | EBI | MGI Sequence Detail 993 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 4
      Antibodies 5

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1495, MGD-MRK-16273, MGI:88129
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 13
      Phenotypes 42
    • Earliest
      J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
    • Latest
      J:388982 Hariton WVJ, et al., A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling. iScience. 2023 Dec 15;26(12):108568
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory