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Dsg3
Gene Detail
 Symbol
Name
ID
Dsg3
desmoglein 3
MGI:99499
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr18:20510304-20541310 bp, + strand
From NCBI annotation of GRCm38

  31007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dsg3

Human
homologs
Human Homolog DSG3, desmoglein 3
NCBI Gene ID 1830
neXtProt AC  NX_P32926
Human Synonyms  CDHF6, PVA
Human Chr (Location)  18q12.1; chr18:31447769-31478702 (+)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Spontaneous(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life.
 
Human Diseases Modeled Using Mouse Dsg3 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell adhesion, homophilic cell adhesion
Component cell junction, desmosome, ...
Function calcium ion binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (17)    Tissues (15)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 2
Western blot 2
RT-PCR 13
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000056632 (Evidence)
Entrez Gene13512 (Evidence)
UniGene106811
DFCITC1589185, TC1595352
DoTSDT.87035019, DT.91445917
Consensus CDS ProjectCCDS29083.1
International Mouse Knockout Project StatusDsg3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13512 NCBI Gene Model | MGI Sequence Detail 31007 C57BL/6J ±  kb
transcript NM_030596 RefSeq | MGI Sequence Detail 4108 C57BL/6 
polypeptide O35902 UniProt | EBI | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR015919 Cadherin-like
InterPro IPR027397 Catenin binding domain
InterPro IPR009123 Desmoglein
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006708 desmoglein-3
Graphical View of Protein Domain Structure
References (Earliest) J:13702 Fox S, et al., Balding (bal). Mouse News Lett. 1977;56:40
(Latest) J:205362 Hata T, et al., Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus. J Immunol. 2013 Jul 1;191(1):83-90
All references(67)
Other
accession IDs
MGD-MRK-1495, MGD-MRK-16273, MGI:88129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory