Dsg3
Gene Detail

Symbol Name ID

Dsg3 desmoglein 3 MGI:99499

Feature Type

protein coding gene

Genetic Map

Chromosome 18

11.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr18:20510304-20541310 bp, + strand From NCBI annotation of GRCm38   31007 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dsg3

Human homologs

Human Homolog		DSG3, desmoglein 3
NCBI Gene ID		1830
neXtProt AC		NX_P32926
Human Synonyms		CDHF6, PVA
Human Chr (Location)		18q12.1; chr18:29027732-29058665 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Spontaneous(3)
 

Homozygous mutants display runting from decreased food intake due to oropharyngeal epithelial lesions, blisters around snout and eyes, hair loss by weaning, and hair regrowth with bald patches throughout life.

 
Human Diseases Modeled Using Mouse Dsg3 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion, homophilic cell adhesion
Component	cell junction, desmosome, ...
Function	calcium ion binding, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (17)    Tissues (15)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Immunohistochemistry	2
Western blot	2
RT-PCR	13

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000056632 (Evidence)
Entrez Gene	13512 (Evidence)
UniGene	106811
DFCI	TC1589185, TC1595352
DoTS	DT.87035019, DT.91445917
Consensus CDS Project	CCDS29083.1
International Mouse Knockout Project Status	Dsg3

Sequences

Length	Strain/Species
genomic	13512	NCBI Gene Model | MGI Sequence Detail	31007	C57BL/6J
transcript	NM_030596	RefSeq | MGI Sequence Detail	4108	C57BL/6
polypeptide	O35902	UniProt | EBI | MGI Sequence Detail	993	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(146 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR015919	Cadherin-like
InterPro	IPR027397	Catenin binding domain
InterPro	IPR009123	Desmoglein
InterPro	IPR009122	Desmosomal cadherin
Protein Ontology	PR:000006708	desmoglein-3

Graphical View of Protein Domain Structure

References

(Earliest) J:13702 Fox S, et al., Balding (bal). Mouse News Lett. 1977;56:40
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(65)

Other accession IDs

MGD-MRK-1495, MGD-MRK-16273, MGI:88129