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Brd2
Gene Detail
 Symbol
Name
ID
Brd2
bromodomain containing 2
MGI:99495
Synonyms D17H6S113E, Frg-1, Fsrg1, Ring3, Rnf3
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:34112023-34122634 bp, - strand
From VEGA annotation of GRCm38

  10612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74540  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Brd2

Human
homologs
Human Homolog BRD2, bromodomain containing 2
NCBI Gene ID 6046
neXtProt AC  NX_P25440
Human Synonyms  D6S113E, FSH, FSRG1, NAT, RING3, RNF3
Human Chr (Location)  6p21.3; chr6:32968660-32981505 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(17) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality during organogenesis with decreased embryo size, decreased cell proliferation, a delay in the cell cycle, and increased cell death. Heterozygous mice also display decreased cell proliferation.
 
Phenotype Images(3)
Interactions
Brd2 interacts with 364 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process chromatin modification, nucleosome assembly, ...
Component cytoplasm, nucleus
Function chromatin binding, lysine-acetylated histone binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (164)    Tissues (92)    Images (28)
Theiler Stages: 2, 3, 4, 5, 15, 17, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 146
Northern blot 4
RT-PCR 14
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(9) cDNA(27) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017279 (Evidence)
Ensembl Gene ModelENSMUSG00000024335 (Evidence)
Entrez Gene14312 (Evidence)
DFCITC1573299, TC1602019, TC1602931, TC1629944, TC1667520, TC1669519
DoTSDT.101332750, DT.101710517, DT.102548498, DT.110514165, DT.110570205, DT.55132971, DT.97367132, DT.97367138, DT.97382619, DT.99864736
NIA Mouse Gene IndexU037705
Consensus CDS ProjectCCDS28641.1, CCDS37578.1
International Mouse Knockout Project StatusBrd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017279 VEGA Gene Model | MGI Sequence Detail 10612 C57BL/6J ±  kb
transcript OTTMUST00000041915 VEGA | MGI Sequence Detail 4483 Not Applicable 
polypeptide OTTMUSP00000018852 VEGA | MGI Sequence Detail 798 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(30) UniProt(7)
Polymorphisms SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR027353 NET domain
Protein Ontology PR:000004806 bromodomain-containing protein 2
References (Earliest) J:17944 Hanson IM, et al., Colinearity of novel genes in the class II regions of the MHC in mouse and human. Immunogenetics. 1991;34(1):5-11
(Latest) J:198763 Garcia-Gutierrez P, et al., Association of bromodomain BET proteins with chromatin requires dimerization through the conserved motif B. J Cell Sci. 2012 Aug 1;125(Pt 15):3671-80
All references(53)
Other
accession IDs
MGD-MRK-16269, MGI:2147056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory