Brd2 MGI Mouse Gene Detail - MGI:99495 - bromodomain containing 2

Symbol

Brd2
Name

bromodomain containing 2
Synonyms

D17H6S113E, Frg-1, Fsrg1, Ring3, Rnf3

Feature Type

protein coding gene
IDs

MGI:99495
NCBI Gene: 14312
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr17:34330993-34341581 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.98 cM, cytoband D
Mapping Data

5 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99495	protein coding gene	Chr17:34330993-34341608 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023557	protein coding gene	Chr17:34089600-34100217 (-)
A/J	MGP_AJ_G0023521	protein coding gene	Chr17:32904382-32914976 (-)
AKR/J	MGP_AKRJ_G0023484	protein coding gene	Chr17:33320693-33331287 (-)
BALB/cJ	MGP_BALBcJ_G0023523	protein coding gene	Chr17:33079115-33089710 (-)
C3H/HeJ	MGP_C3HHeJ_G0023284	protein coding gene	Chr17:33677238-33687906 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023964	protein coding gene	Chr17:35392963-35403561 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021442	protein coding gene	Chr17:30444494-30455128 (-)
CAST/EiJ	MGP_CASTEiJ_G0022783	protein coding gene	Chr17:33776850-33787450 (-)
CBA/J	MGP_CBAJ_G0023261	protein coding gene	Chr17:36794145-36804739 (-)
DBA/2J	MGP_DBA2J_G0023392	protein coding gene	Chr17:32289168-32299763 (-)
FVB/NJ	MGP_FVBNJ_G0023356	protein coding gene	Chr17:32156794-32168221 (-)
LP/J	MGP_LPJ_G0023467	protein coding gene	Chr17:34365303-34375912 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023379	protein coding gene	Chr17:35829932-35840527 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024006	protein coding gene	Chr17:33671901-33682494 (-)
PWK/PhJ	MGP_PWKPhJ_G0022533	protein coding gene	Chr17:31216770-31227430 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022348	protein coding gene	Chr17:31621138-31631698 (-)
WSB/EiJ	MGP_WSBEiJ_G0022844	protein coding gene	Chr17:33685100-33695702 (-)

Human Ortholog

BRD2, bromodomain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BRD2, bromodomain containing 2
Synonyms

BRD2-IT1, D6S113E, FSH, FSHRG1, FSRG1, NAT, O27.1.1, RING3, RNF3
Links

HGNC:1103

NCBI Gene ID: 6046

neXtProt AC: NX_P25440

UniProt: P25440
Chr Location

6p21.32; chr6:32968594-32981505 (+) GRCh38

MGI Vertebrate Homology

Brd2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BRD2
Gene Tree

Brd2

Diseases

4 with human BRD2 associations

				Human Disease	Mouse Models
				B-cell lymphoma IDs B-cell lymphoma DOID:707 MESH:D016393 NCI:C3457 UMLS_CUI:C0079731
				B-lymphoblastic leukemia/lymphoma IDs B-lymphoblastic leukemia/lymphoma DOID:0080630 NCI:C8936 UMLS_CUI:C0862030
				juvenile myoclonic epilepsy IDs juvenile myoclonic epilepsy DOID:4890 DOID:0050326 MESH:D020190 NCI:C84796 OMIM:254770 ORDO:307 ORDO:862 UMLS_CUI:C0270853
				photosensitivity disease IDs photosensitivity disease DOID:3159 MESH:D010787 UMLS_CUI:C0031762

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

129 phenotypes from 6 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

4
Gene trapped

15
Targeted

5
Transgenic

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display embryonic lethality during organogenesis with decreased embryo size, decreased cell proliferation, a delay in the cell cycle, and increased cell death. Heterozygous mice also display decreased cell proliferation.

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All GO Annotations

35
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

99
cDNA Data

26
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BRD2

Xenbase brd2

ZFIN brd2a, brd2b

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All Sequences

118
RefSeq

19
UniProt

7
CCDS

CCDS28641.1, CCDS37578.1

Ensembl

ENSMUSG00000024335 (Evidence)
NCBI Gene

14312

			Length	Strain/Species	Flank
genomic	14312	NCBI Gene Model \| MGI Sequence Detail	10589	C57BL/6J	± kb
transcript	NM_001204973	RefSeq \| MGI Sequence Detail	4685	ZRU/MplStud
polypeptide	Q7JJ13	UniProt \| EBI \| MGI Sequence Detail	798	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004806 bromodomain-containing protein 2

(term hierarchy)
InterPro Domains

IPR043508 Brdt, bromodomain, repeat I

IPR043509 Brdt, bromodomain, repeat II

IPR001487 Bromodomain

IPR018359 Bromodomain, conserved site

IPR036427 Bromodomain-like superfamily

IPR027353 NET domain

IPR038336 NET domain superfamily

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All nucleic 40

Genomic 9

cDNA 28

Primer pair 3

Microarray probesets 4

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MGD-MRK-16269, MGI:2147056

Summaries

All 74

Developmental Gene Expression 15

Gene Ontology 9

Phenotypes 25
Earliest

J:17944 Hanson IM, et al., Colinearity of novel genes in the class II regions of the MHC in mouse and human. Immunogenetics. 1991;34(1):5-11
Latest

J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027

TSS for Brd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147536	Chr17:34341609-34341620 (-)	-34 bp
Tssr147535	Chr17:34341546-34341606 (-)	5 bp
Tssr147534	Chr17:34341285-34341349 (-)	264 bp
Tssr147533	Chr17:34341233-34341256 (-)	336 bp
Tssr147532	Chr17:34341180-34341215 (-)	383 bp
Tssr147531	Chr17:34340918-34340946 (-)	649 bp
Tssr147530	Chr17:34339967-34340013 (-)	1,591 bp
Tssr147529	Chr17:34339943-34339965 (-)	1,627 bp
Tssr147528	Chr17:34339352-34339396 (-)	2,207 bp
Tssr147527	Chr17:34339285-34339308 (-)	2,284 bp
Tssr147526	Chr17:34338291-34338314 (-)	3,278 bp
Tssr147525	Chr17:34337450-34337496 (-)	4,108 bp
Tssr147524	Chr17:34335981-34336000 (-)	5,590 bp
Tssr147523	Chr17:34335303-34335316 (-)	6,271 bp
Tssr147522	Chr17:34335265-34335283 (-)	6,307 bp
Tssr147521	Chr17:34335245-34335261 (-)	6,328 bp
Tssr147520	Chr17:34335202-34335217 (-)	6,371 bp
Tssr147519	Chr17:34334550-34334567 (-)	7,022 bp
Tssr147518	Chr17:34334473-34334546 (-)	7,071 bp
Tssr147517	Chr17:34334422-34334472 (-)	7,134 bp
Tssr147516	Chr17:34334194-34334238 (-)	7,365 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23