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Brd2 Gene Detail
Summary
  • Symbol
    Brd2
  • Name
    bromodomain containing 2
  • Synonyms
    D17H6S113E, Frg-1, Fsrg1, Ring3, Rnf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99495
    NCBI Gene: 14312
  • Gene Overview
    MyGene.info: BRD2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34112023-34122634 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10612 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM, cytoband D
  • Mapping Data
    5 experiments
Homology
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  • Human Ortholog
    BRD2, bromodomain containing 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    BRD2, bromodomain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRD2-IT1, D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3
  • Links
    NCBI Gene ID: 6046
    neXtProt AC: NX_P25440
    UniProt: P25440

  • Chr Location
    6p21.32; chr6:32968660-32981505 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74540
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BRD2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    124 phenotypes from 6 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with decreased embryo size, decreased cell proliferation, a delay in the cell cycle, and increased cell death. Heterozygous mice also display decreased cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017279 VEGA Gene Model | MGI Sequence Detail 10612 C57BL/6J ±  kb
    transcript OTTMUST00000041915 VEGA | MGI Sequence Detail 4483 Not Applicable  
    polypeptide OTTMUSP00000018852 VEGA | MGI Sequence Detail 798 Not Applicable  
    For the selected sequence
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 39
      Genomic 9
      cDNA 28
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
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    MGD-MRK-16269, MGI:2147056
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 12
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:17944 Hanson IM, et al., Colinearity of novel genes in the class II regions of the MHC in mouse and human. Immunogenetics. 1991;34(1):5-11
    • Latest
      J:251939 Cheung KL, et al., Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell. 2017 Mar 16;65(6):1068-1080.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory