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Cebpa
Gene Detail
 Symbol
Name
ID
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
MGI:99480
Synonyms Cebp, C/ebpalpha, C/EBP alpha
Feature Type protein coding gene
Genetic Map
Chromosome 7
21.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr7:35119293-35121926 bp, + strand
From Ensembl annotation of GRCm38

  2634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3211  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpa

Human
homologs
Human Homolog CEBPA, CCAAT/enhancer binding protein (C/EBP), alpha
NCBI Gene ID 1050
neXtProt AC  NX_P49715
Human Synonyms  CEBP, C/EBP-alpha
Human Chr (Location)  19q13.1; chr19:33299934-33302564 (-)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Chemically induced (ENU)(1) Targeted(21)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects of the liver, neutrophils, lung, and brown fat, resulting in impaired glycogen storage and lipid accumulation, hypoglycemia, reduced uncoupling protein, and neonatal lethality.
 
Human Diseases Modeled Using Mouse Cebpa (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process brown fat cell differentiation, cell maturation, ...
Component nuclear matrix, nucleus, ...
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (62 records)
Data Summary: Results (292)    Tissues (129)    Images (58)
Theiler Stages: 2, 3, 4, 5, 11, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 22
RNA in situ 179
Northern blot 49
Western blot 8
RT-PCR 34
cDNA source data(104)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(120) Genomic(1) cDNA(112) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000034957 (Evidence)
Entrez Gene12606 (Evidence)
UniGene349667
DFCITC1577649
DoTSDT.533595
NIA Mouse Gene IndexU007965
Consensus CDS ProjectCCDS21145.1
International Mouse Knockout Project StatusCebpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034957 Ensembl Gene Model | MGI Sequence Detail 2634 C57BL/6J ±  kb
transcript ENSMUST00000042985 Ensembl | MGI Sequence Detail 2634 Not Applicable 
polypeptide ENSMUSP00000096129 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(2)
Polymorphisms RFLP(8) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016468 CCAAT/enhancer-binding
Protein Ontology PR:000005307 CCAAT/enhancer-binding protein alpha
References (Earliest) J:9999 Xanthopoulos KG, et al., The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet. 1989;50(2-3):174-5
(Latest) J:208818 Hasemann MS, et al., C/EBPalpha is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet. 2014 Jan;10(1):e1004079
All references(234)
Other
accession IDs
MGD-MRK-16254, MGD-MRK-1916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory