Cebpa
Gene Detail

Symbol Name ID

Cebpa CCAAT/enhancer binding protein (C/EBP), alpha MGI:99480

Synonyms

Cebp, C/ebpalpha, C/EBP alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 7

21.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr7:35119293-35121926 bp, + strand From Ensembl annotation of GRCm38   2634 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3211  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpa

Human homologs

Human Homolog		CEBPA, CCAAT/enhancer binding protein (C/EBP), alpha
NCBI Gene ID		1050
neXtProt AC		NX_P49715
Human Synonyms		CEBP, C/EBP-alpha
Human Chr (Location)		19q13.1; chr19:33790840-33793430 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CEBPA

Alleles and phenotypes

All alleles(22) : Targeted(21) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit defects of the liver, neutrophils, lung, and brown fat, resulting in impaired glycogen storage and lipid accumulation, hypoglycemia, reduced uncoupling protein, and neonatal lethality.

 
Human Diseases Modeled Using Mouse Cebpa (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (58 annotations)

Process	brown fat cell differentiation, cell maturation, ...
Component	nuclear matrix, nucleus, ...
Function	DNA binding, HMG box domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (273)    Tissues (120)    Images (44)
Theiler Stages: 2, 3, 4, 5, 11, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	22
RNA in situ	160
Northern blot	49
Western blot	8
RT-PCR	34

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(113) Genomic(1) cDNA(105) Primer pair(6) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034957 (Evidence)
Entrez Gene	12606 (Evidence)
UniGene	349667
DFCI	TC1577649
DoTS	DT.533595
NIA Mouse Gene Index	U007965
Consensus CDS Project	CCDS21145.1
International Mouse Knockout Project Status	Cebpa

Sequences

Length	Strain/Species
genomic	ENSMUSG00000034957	Ensembl Gene Model | MGI Sequence Detail	2634	C57BL/6J
transcript	ENSMUST00000042985	Ensembl | MGI Sequence Detail	2634	Not Applicable
polypeptide	ENSMUSP00000096129	Ensembl | MGI Sequence Detail	359	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(8) : SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR016468	CCAAT/enhancer-binding
Protein Ontology	PR:000005307	CCAAT/enhancer-binding protein alpha

References

(Earliest) J:9999 Xanthopoulos KG, et al., The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet. 1989;50(2-3):174-5
(Latest) J:196138 Chen W, et al., C/EBPalpha regulates osteoclast lineage commitment. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7294-9
All references(215)

Other accession IDs

MGD-MRK-16254, MGD-MRK-1916