About   Help   FAQ
Cebpa
Gene Detail
Symbol

Name
ID
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
MGI:99480
Synonyms
Cebp, C/ebpalpha, C/EBP alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 7
21.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr7:35119293-35121926 bp, + strand
From Ensembl annotation of GRCm38

  2634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3211  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CEBPA
Protein SuperFamily: CCAAT/enhancer-binding protein
Gene Tree: Cebpa

Human
homologs
CEBPA, CCAAT/enhancer binding protein (C/EBP), alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1050
neXtProt AC: NX_P49715

Human Synonyms: CEBP, C/EBP-alpha

Human Chr (Location): 19q13.1; chr19:33299934-33302564 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CEBPA

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Targeted(21)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit defects of the liver, neutrophils, lung, and brown fat, resulting in impaired glycogen storage and lipid accumulation, hypoglycemia, reduced uncoupling protein, and neonatal lethality.
 
Human Diseases Modeled in Mice Using Cebpa (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Cebpa interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (100 annotations)
Process brown fat cell differentiation, cell maturation, ...
Component CHOP-C/EBP complex, nuclear matrix, ...
Function DNA binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (284)    Tissues (126)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 178
Northern blot 49
Western blot 8
RT-PCR 27
cDNA source data(104)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cebpa ; ZFIN cebpa    NEW 
Molecular
reagents
All nucleic(120) Genomic(1) cDNA(112) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000034957 (Evidence)
Entrez Gene 12606 (Evidence)
UniGene 349667
DFCI TC1577649
DoTS DT.533595
NIA Mouse Gene Index U007965
Consensus CDS Project CCDS21145.1
International Mouse Phenotyping Consortium Status Cebpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034957 Ensembl Gene Model | MGI Sequence Detail 2634 C57BL/6J ±  kb
transcript ENSMUST00000042985 Ensembl | MGI Sequence Detail 2634 Not Applicable 
polypeptide ENSMUSP00000096129 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(8) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016468 CCAAT/enhancer-binding
Protein Ontology PR:000005307 CCAAT/enhancer-binding protein alpha
References
(Earliest) J:9999 Xanthopoulos KG, et al., The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet. 1989;50(2-3):174-5
(Latest) J:218426 Kahraman S, et al., Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E906-18
All references(246)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16254, MGD-MRK-1916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory