About   Help   FAQ
Cebpa Gene Detail
Summary
  • Symbol
    Cebpa
  • Name
    CCAAT/enhancer binding protein (C/EBP), alpha
  • Synonyms
    Cebp, C/ebpalpha, C/EBP alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99480
    NCBI Gene: 12606
  • Gene Overview
    MyGene.info: CEBPA
Location & Maps
more
  • Sequence Map
    Chr7:35119293-35121928 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2636 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 21.02 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    CEBPA, CCAAT/enhancer binding protein alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CEBPA, CCAAT/enhancer binding protein alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CEBP, C/EBP-alpha
  • Links
    NCBI Gene ID: 1050
    neXtProt AC: NX_P49715

  • Chr Location
    19q13.1; chr19:33299934-33302564 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Cebpa mouse models; 1 with human CEBPA associations

Human Disease Mouse Models
       Leukemia, Acute Myeloid; AML   OMIM: 601626 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    108 phenotypes from 17 alleles in 18 genetic backgrounds
    57 phenotypes from multigenic genotypes
    2 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Targeted
    21
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit defects of the liver, neutrophils, lung, and brown fat, resulting in impaired glycogen storage and lipid accumulation, hypoglycemia, reduced uncoupling protein, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058155 VEGA Gene Model | MGI Sequence Detail 2636 C57BL/6J ±  kb
transcript OTTMUST00000142810 VEGA | MGI Sequence Detail 2626 Not Applicable  
polypeptide OTTMUSP00000074467 VEGA | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005307 CCAAT/enhancer-binding protein alpha
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR031106 CCAAT/enhancer-binding protein C/EBP
    IPR016468 CCAAT/enhancer-binding protein, chordates
Molecular
Reagents
less
  • All nucleic 120
    Genomic 1
    cDNA 112
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16254, MGD-MRK-1916
References
more
  • Summaries
    All 254
    Developmental Gene Expression 70
    Diseases 1
    Gene Ontology 46
    Phenotypes 92
  • Earliest
    J:9999 Xanthopoulos KG, et al., The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet. 1989;50(2-3):174-5
  • Latest
    J:228795 Tunster SJ, et al., The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Dev Biol. 2016 Jan 1;409(1):251-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory