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Ifit1 Gene Detail
Summary
  • Symbol
    Ifit1
  • Name
    interferon-induced protein with tetratricopeptide repeats 1
  • Synonyms
    Ifi56, ISG56
  • Feature Type
    protein coding gene
  • IDs
    MGI:99450
    NCBI Gene: 15957
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34640889-34650009 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99450
protein coding gene Chr19:34640871-34650009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025064
protein coding gene Chr19:33400062-33409512 (+)
A/J MGP_AJ_G0025040
protein coding gene Chr19:31784595-31793723 (+)
AKR/J MGP_AKRJ_G0025008
protein coding gene Chr19:32879250-32888360 (+)
BALB/cJ MGP_BALBcJ_G0025038
protein coding gene Chr19:31900395-31909985 (+)
C3H/HeJ MGP_C3HHeJ_G0024797
protein coding gene Chr19:32960823-32969879 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025479
protein coding gene Chr19:34399342-34411059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022897
protein coding gene Chr19:31212033-31214611 (+)
CAST/EiJ MGP_CASTEiJ_G0024264
protein coding gene Chr19:32708342-32717503 (+)
CBA/J MGP_CBAJ_G0024774
protein coding gene Chr19:35982953-35992959 (+)
DBA/2J MGP_DBA2J_G0024906
protein coding gene Chr19:31683941-31693231 (+)
FVB/NJ MGP_FVBNJ_G0024867
protein coding gene Chr19:31509193-31518291 (+)
LP/J MGP_LPJ_G0024992
protein coding gene Chr19:33524068-33533248 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024898
protein coding gene Chr19:35769167-35778815 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025537
protein coding gene Chr19:32957644-32966774 (+)
PWK/PhJ MGP_PWKPhJ_G0024016
protein coding gene Chr19:31493825-31504382 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023816
protein coding gene Chr19:31817487-31826978 (+)
WSB/EiJ MGP_WSBEiJ_G0024331
protein coding gene Chr19:33032483-33041700 (+)



Homology
more
  • Human Ortholog
    IFIT1, interferon induced protein with tetratricopeptide repeats 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    IFIT1, interferon induced protein with tetratricopeptide repeats 1
    Orthology source: HGNC
  • Synonyms
    C56, G10P1, IFI56, IFI-56, IFI-56K, IFIT-1, IFNAI1, ISG56, P56, RNM561
  • Links
    NCBI Gene ID: 3434
    neXtProt AC: NX_P09914
    UniProt: P09914

  • Chr Location
    10q23.31; chr10:89392546-89406487 (+)  GRCh38.p7

  • Human Ortholog
    IFIT1B, interferon induced protein with tetratricopeptide repeats 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA149I23.6, IFIT1L
  • Links
    NCBI Gene ID: 439996
    neXtProt AC: NX_Q5T764
    UniProt: Q5T764

  • Chr Location
    10q23.31; chr10:89378056-89385205 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered response to vesicular stomatitis virus (VSV) infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15957 NCBI Gene Model | MGI Sequence Detail 9121 C57BL/6J ±  kb
transcript NM_008331 RefSeq | MGI Sequence Detail 2638 C57BL/6  
polypeptide Q64282 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000033988 rodent-type interferon-induced protein with tetratricopeptide repeats 1
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 76
    Genomic 2
    cDNA 72
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-16219
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:21469 Bluyssen HA, et al., Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Genomics. 1994 Nov 1;24(1):137-48
  • Latest
    J:270825 Uehara R, et al., Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development. Cell Rep. 2018 Oct 30;25(5):1135-1145.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory