Sequence Detail

ID/Version

Q64282 Q99L77 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Antiviral innate immune response effector IFIT1 {ECO:0000305|PubMed:21085181};AltName: Full=Glucocorticoid-attenuated response gene 16 protein; Short=GARG-16;AltName: Full=Interferon-induced 56 kDa protein; Short=IFI-56K;

Provider

SWISS-PROT

Sequence

Polypeptide 463 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ifit1	interferon-induced protein with tetratricopeptide repeats 1	25	110	6	8

Sequence references in MGI

J:21469 Bluyssen HA, et al., Structure, chromosome localization, and regulation of expression of the interferon-regulated mouse Ifi54/Ifi56 gene family. Genomics. 1994 Nov 1;24(1):137-48
J:43666 Smith JB, et al., The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains. Arch Biochem Biophys. 1996 Jun 15;330(2):290-300
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:187561 Daffis S, et al., 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature. 2010 Nov 18;468(7322):452-6
J:192650 Li HT, et al., The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A. Mol Cell Biochem. 2010 Apr;337(1-2):101-10
J:195385 Szretter KJ, et al., 2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo. PLoS Pathog. 2012;8(5):e1002698
J:234097 Daugherty MD, et al., Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals. Elife. 2016;5:e14228
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302651 Mears HV, et al., Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c. J Biol Chem. 2020 Dec 18;295(51):17781-17801