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Btc Gene Detail
Summary
  • Symbol
    Btc
  • Name
    betacellulin, epidermal growth factor family member
  • Feature Type
    protein coding gene
  • IDs
    MGI:99439
    NCBI Gene: 12223
  • Gene Overview
    MyGene.info: BTC
Location & Maps
more
  • Sequence Map
    Chr5:91357261-91402994 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45734 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    BTC, betacellulin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    BTC, betacellulin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 685
    neXtProt AC: NX_P35070

  • Chr Location
    4q13.3; chr4:74744759-74794672 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1309
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: BTC
  • Gene Tree
    Btc
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    3
  • Genomic Mutations
    4 involving Btc
Mice homozygous for a knock-out allele are viable and fertile and exhibit no overt defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055524 VEGA Gene Model | MGI Sequence Detail 45734 C57BL/6J ±  kb
transcript OTTMUST00000137424 VEGA | MGI Sequence Detail 2876 Not Applicable  
polypeptide OTTMUSP00000072376 VEGA | MGI Sequence Detail 177 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    521 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16203
References
more
  • Summaries
    All 44
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:22281 Shing Y, et al., Betacellulin: a mitogen from pancreatic beta cell tumors. Science. 1993 Mar 12;259(5101):1604-7
  • Latest
    J:211269 Hosur V, et al., Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2200-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory