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Opn1sw
Gene Detail
 Symbol
Name
ID
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
MGI:99438
Synonyms Bcp, Blue Cone Opsin, Blue Opsin, Blue/UV Opsin, Short Wavelength Sensitive opsin, S Opsin, SWS opsin, UV cone pigment
Feature Type protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:29376671-29388468 bp, - strand
From VEGA annotation of GRCm38

  11798 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: animal opsin
Gene Tree: Opn1sw

Human
homologs
Human Homolog OPN1SW, opsin 1 (cone pigments), short-wave-sensitive
NCBI Gene ID 611
neXtProt AC  NX_P03999
Human Synonyms  BCP, BOP, CBT
Human Chr (Location)  7q32.1; chr7:128772489-128775790 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human OPN1SW
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for a knock-in allele exhibit abnormal cone physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process G-protein coupled receptor signaling pathway, phototransduction, ...
Component cell body, integral component of membrane, ...
Function G-protein coupled receptor activity, photoreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (39 records)
Data Summary: Results (81)    Tissues (54)    Images (11)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 8
Northern blot 4
RT-PCR 68
cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(23) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022747 (Evidence)
Ensembl Gene ModelENSMUSG00000058831 (Evidence)
Entrez Gene12057 (Evidence)
UniGene56987
DFCITC1583611
NIA Mouse Gene IndexU152364
Consensus CDS ProjectCCDS19959.1
International Mouse Knockout Project StatusOpn1sw
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022747 VEGA Gene Model | MGI Sequence Detail 11798 C57BL/6J ±  kb
transcript OTTMUST00000054593 VEGA | MGI Sequence Detail 2410 Not Applicable 
polypeptide OTTMUSP00000026075 VEGA | MGI Sequence Detail 346 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001760 Opsin
InterPro IPR001521 Opsin, blue sensitive
InterPro IPR027430 Visual pigments (opsins) retinal binding site
Protein Ontology PR:000001195 short-wave-sensitive opsin 1
References (Earliest) J:49034 Weitz CJ, et al., Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment [letter]. Am J Hum Genet. 1992 Aug;51(2):444-6
(Latest) J:203642 Hufnagel RB, et al., Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013 May;54:108-20
All references(76)
Other
accession IDs
MGD-MRK-16202, MGI:2141695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory