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Prkci Gene Detail
Summary
  • Symbol
    Prkci
  • Name
    protein kinase C, iota
  • Synonyms
    2310021H13Rik, aPKClambda, Pkci, Pkcl, PKClambda, Prkcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:99260
    NCBI Gene: 18759
  • Gene Overview
    MyGene.info: PRKCI
Location & Maps
more
  • Sequence Map
    Chr3:30995747-31052959 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57213 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 14.65 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PRKCI, protein kinase C iota
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKCI, protein kinase C iota
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DXS1179E, nPKC-iota, PKCI
  • Links
    NCBI Gene ID: 5584
    neXtProt AC: NX_P41743

  • Chr Location
    3q26.2; chr3:170222432-170305982 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Prkci mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 7 alleles in 9 genetic backgrounds
    4 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    152
  • Gene trapped
    140
  • Radiation induced
    1
  • Targeted
    11
  • Genomic Mutations
    1 involving Prkci
  • Incidental Mutations
Homozygous inactivation of this gene leads to complete embryonic lethality. Muscle-specific deletion of this gene impairs glucose transport and induces metabolic and diabetic syndromes. Podocyte-specific deletion leads to altered podocyte architecture, proteinuria, and accelerated renal failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032732 VEGA Gene Model | MGI Sequence Detail 57213 C57BL/6J ±  kb
transcript OTTMUST00000081432 VEGA | MGI Sequence Detail 4708 Not Applicable  
polypeptide OTTMUSP00000043573 VEGA | MGI Sequence Detail 595 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    370 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 19
    Primer pair 6
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16019, MGD-MRK-26062, MGI:104625, MGI:1919155, MGI:2139701
References
more
  • Summaries
    All 131
    Developmental Gene Expression 59
    Diseases 2
    Gene Ontology 14
    Phenotypes 36
  • Earliest
    J:17835 Akimoto K, et al., A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem. 1994 Apr 29;269(17):12677-83
  • Latest
    J:231671 Xu B, et al., Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct. Dev Biol. 2016 Apr 15;412(2):219-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory