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Xist Gene Detail
Summary
  • Symbol
    Xist
  • Name
    inactive X specific transcripts
  • Feature Type
    lincRNA gene
  • IDs
    MGI:98974
    NCBI Gene: 213742
  • Gene Overview
    MyGene.info: XIST
Location & Maps
more
  • Sequence Map
    ChrX:103460375-103483217 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22843 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    XIST, X inactive specific transcript (non-protein coding)
  • Human Ortholog
    XIST, X inactive specific transcript (non-protein coding)
    Orthology source: HGNC
  • Synonyms
    DXS1089, DXS399E, LINC00001, NCRNA00001, swd66, SXI1
  • Links
    NCBI Gene ID: 7503

  • Chr Location
    Xq13.2; chrX:73820651-73852753 (-)  GRCh38.p2

  • HCOP
    human homology predictions: XIST
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 18 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Targeted
    22
  • Genomic Mutations
    1 involving Xist
Xist function in X-inactivation is disrupted in females carrying a null mutation. Depending on maternal or paternal derivation of the mutation, females survive or die in early embryogenesis. In either case, X-inactivation is non-random and abnormal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018295 VEGA Gene Model | MGI Sequence Detail 22843 C57BL/6J ±  kb
transcript NR_001463 RefSeq | MGI Sequence Detail 17918 Not Specified  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
  • RFLP
Molecular
Reagents
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  • All nucleic 147
    Genomic 93
    cDNA 32
    Primer pair 15
    Other 7

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-15474, MGI:2147863
References
more
  • Summaries
    All 209
    Developmental Gene Expression 55
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:2970 Brown SD, XIST and the mapping of the X chromosome inactivation centre. Bioessays. 1991 Nov;13(11):607-12
  • Latest
    J:227859 Sun S, et al., Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14415-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory