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Gene Detail
wingless-type MMTV integration site family, member 5A
Synonyms 8030457G12Rik, Wnt-5a
Feature Type protein coding gene
Genetic Map
Chromosome 14
16.80 cM
Detailed Genetic Map ± 1 cM

Mapping data(12)
Sequence Map
Chr14:28504750-28527447 bp, + strand
From VEGA annotation of GRCm38

  22698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt5a

Human Homolog WNT5A, wingless-type MMTV integration site family, member 5A
NCBI Gene ID 7474
neXtProt AC  NX_P41221
Human Synonyms  hWNT5A
Human Chr (Location)  3p21-p14; chr3:55465715-55487642 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human WNT5A
alleles, and
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
Human Diseases Modeled Using Mouse Wnt5a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Wnt5a interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (188 annotations)
Process activation of JUN kinase activity, activation of MAPK activity, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, frizzled-2 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (234 records)
Data Summary: Results (1045)    Tissues (670)    Images (162)
Theiler Stages: 1, 2, 3, 5, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 730
Northern blot 29
RT-PCR 280
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(63) Genomic(1) cDNA(29) Primer pair(23) Other(10)
Microarray probesets(8)
Other database
VEGA Gene ModelOTTMUSG00000021010 (Evidence)
Ensembl Gene ModelENSMUSG00000021994 (Evidence)
Entrez Gene22418 (Evidence)
DFCITC1580129, TC1606400, TC1614372, TC1634373
DoTSDT.101725912, DT.55204109
NIA Mouse Gene IndexU043385
Consensus CDS ProjectCCDS26888.1, CCDS56946.1
International Mouse Knockout Project StatusWnt5a
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021010 VEGA Gene Model | MGI Sequence Detail 22698 C57BL/6J ±  kb
transcript OTTMUST00000049665 VEGA | MGI Sequence Detail 7009 Not Applicable 
polypeptide OTTMUSP00000023050 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(1)
Polymorphisms RFLP(4) : SNPs within 2kb(108 from dbSNP Build 137)
InterPro IPR005817 Wnt
InterPro IPR026538 Wnt-5a protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017445 protein Wnt-5a
References (Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:210471 Okamoto M, et al., Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis. Sci Rep. 2014;4:4493
All references(347)
Disease annotation references (1)
accession IDs
MGD-MRK-15443, MGD-MRK-15453, MGI:1924815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory