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Wnt5a Gene Detail
Summary
  • Symbol
    Wnt5a
  • Name
    wingless-type MMTV integration site family, member 5A
  • Synonyms
    8030457G12Rik, Wnt-5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98958
    NCBI Gene: 22418
  • Gene Overview
    MyGene.info: WNT5A
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:28505473-28527448 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.80 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98958
protein coding gene Chr14:28504750-28527448 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021095
protein coding gene Chr14:21543601-21562779 (+)
A/J MGP_AJ_G0021043
protein coding gene Chr14:20715661-20735129 (+)
AKR/J MGP_AKRJ_G0021020
protein coding gene Chr14:21790686-21814655 (+)
BALB/cJ MGP_BALBcJ_G0021047
protein coding gene Chr14:20820543-20844052 (+)
C3H/HeJ MGP_C3HHeJ_G0020830
protein coding gene Chr14:21654065-21671555 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021479
protein coding gene Chr14:22424363-22443775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019042
protein coding gene Chr14:20830611-20852064 (+)
CAST/EiJ MGP_CASTEiJ_G0020355
protein coding gene Chr14:21338282-21357895 (+)
CBA/J MGP_CBAJ_G0020797
protein coding gene Chr14:23308984-23326470 (+)
DBA/2J MGP_DBA2J_G0020919
protein coding gene Chr14:20792067-20811952 (+)
FVB/NJ MGP_FVBNJ_G0020903
protein coding gene Chr14:20746459-20767722 (+)
LP/J MGP_LPJ_G0020988
protein coding gene Chr14:21856726-21875389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020929
protein coding gene Chr14:22641293-22663797 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021512
protein coding gene Chr14:21561351-21579934 (+)
PWK/PhJ MGP_PWKPhJ_G0020103
protein coding gene Chr14:20208426-20230291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019927
protein coding gene Chr14:21102690-21120713 (+)
WSB/EiJ MGP_WSBEiJ_G0020410
protein coding gene Chr14:21612471-21633922 (+)



Homology
more
  • Human Ortholog
    WNT5A, Wnt family member 5A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT5A, Wnt family member 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hWNT5A
  • Links
    NCBI Gene ID: 7474
    neXtProt AC: NX_P41221
    UniProt: P41221

  • Chr Location
    3p14.3; chr3:55465715-55505261 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Wnt5a mouse models; 1 with human WNT5A associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 5 alleles in 10 genetic backgrounds
    17 phenotypes from multigenic genotypes
    42 images
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22418 NCBI Gene Model | MGI Sequence Detail 21976 C57BL/6J ±  kb
    transcript NM_009524 RefSeq | MGI Sequence Detail 6286 C57BL/6  
    polypeptide P22725 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 1
      cDNA 32
      Primer pair 23
      Other 14

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15443, MGD-MRK-15453, MGI:1924815
    References
    more
    • Summaries
      All 481
      Developmental Gene Expression 309
      Diseases 1
      Gene Ontology 71
      Phenotypes 103
    • Earliest
      J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
    • Latest
      J:264113 Lopez-Escobar B, et al., The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory