Wnt5a
Gene Detail

Symbol Name ID

Wnt5a wingless-related MMTV integration site 5A MGI:98958

Synonyms

8030457G12Rik, Wnt-5a

Feature Type

protein coding gene

Genetic Map

Chromosome 14

16.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr14:28504750-28527447 bp, + strand From VEGA annotation of GRCm38   22698 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt5a

Human homologs

Human Homolog		WNT5A, wingless-type MMTV integration site family, member 5A
NCBI Gene ID		7474
neXtProt AC		NX_P41221
Human Synonyms		hWNT5A
Human Chr (Location)		3p21-p14; chr3:55499743-55521670 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WNT5A

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.

 
Human Diseases Modeled Using Mouse Wnt5a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (182 annotations)

Process	activation of JUN kinase activity, activation of MAPK activity, ...
Component	cell surface, cytoplasm, ...
Function	cytokine activity, frizzled-2 binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (214 records)
Data Summary: Results (881)    Tissues (509)    Images (142)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	560
Northern blot	29
RT-PCR	286

cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(1) cDNA(28) Primer pair(23) Other(8)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000021010 (Evidence)
Ensembl Gene Model	ENSMUSG00000021994 (Evidence)
Entrez Gene	22418 (Evidence)
DFCI	TC1580129, TC1606400, TC1614372, TC1634373
DoTS	DT.101725912, DT.55204109
NIA Mouse Gene Index	U043385
Consensus CDS Project	CCDS26888.1, CCDS56946.1
International Mouse Knockout Project Status	Wnt5a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021010	VEGA Gene Model | MGI Sequence Detail	22698	C57BL/6J
transcript	OTTMUST00000049665	VEGA | MGI Sequence Detail	7009	Not Applicable
polypeptide	OTTMUSP00000023050	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(46) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(4) : SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR026538	Wnt-5a protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017445	protein Wnt-5a

References

(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(319)

Other accession IDs

MGD-MRK-15443, MGD-MRK-15453, MGI:1924815