About   Help   FAQ
Wnt5a Gene Detail
Summary
  • Symbol
    Wnt5a
  • Name
    wingless-type MMTV integration site family, member 5A
  • Synonyms
    8030457G12Rik, Wnt-5a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98958
    NCBI Gene: 22418
  • Gene Overview
    MyGene.info: WNT5A
Location & Maps
more
  • Sequence Map
    Chr14:28504750-28527447 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22698 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WNT5A, Wnt family member 5A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT5A, Wnt family member 5A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hWNT5A
  • Links
    NCBI Gene ID: 7474
    neXtProt AC: NX_P41221

  • Chr Location
    3p21-p14; chr3:55465715-55505261 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Wnt5a mouse models; 1 with human WNT5A associations

Human Disease Mouse Models
       Anorectal Anomalies   OMIM: 107100 View 1 model
       Robinow Syndrome, Autosomal Dominant 1; DRS1   OMIM: 180700
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 4 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    42 images
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021010 VEGA Gene Model | MGI Sequence Detail 22698 C57BL/6J ±  kb
transcript OTTMUST00000049665 VEGA | MGI Sequence Detail 7009 Not Applicable  
polypeptide OTTMUSP00000023050 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    Genomic 1
    cDNA 31
    Primer pair 23
    Other 11

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-15443, MGD-MRK-15453, MGI:1924815
References
more
  • Summaries
    All 385
    Developmental Gene Expression 260
    Diseases 1
    Gene Ontology 67
    Phenotypes 84
  • Earliest
    J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
  • Latest
    J:227252 Hayakawa Y, et al., Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015 Dec 14;28(6):800-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory