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Wnt5a
Gene Detail
Symbol

Name
ID
Wnt5a
wingless-type MMTV integration site family, member 5A
MGI:98958
Synonyms
8030457G12Rik, Wnt-5a
Feature Type
protein coding gene
Genetic Map
Chromosome 14
16.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr14:28504750-28527447 bp, + strand
From VEGA annotation of GRCm38

  22698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT5A
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt5a

Human
homologs
WNT5A, wingless-type MMTV integration site family, member 5A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7474
neXtProt AC: NX_P41221

Human Synonyms: hWNT5A

Human Chr (Location): 3p21-p14; chr3:55465715-55505261 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human WNT5A

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
 
Human Diseases Modeled in Mice Using Wnt5a (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Wnt5a interacts with 415 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (202 annotations)
Process activation of JUN kinase activity, activation of MAPK activity, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, frizzled-2 binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (248 records)
Data Summary: Results (1047)    Tissues (677)    Images (163)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 732
Northern blot 29
RT-PCR 280
cDNA source data(26)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT5A ZFIN wnt5a    NEW 
Molecular
reagents
All nucleic(64) Genomic(1) cDNA(30) Primer pair(23) Other(10)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000021010 (Evidence)
Ensembl Gene Model ENSMUSG00000021994 (Evidence)
Entrez Gene 22418 (Evidence)
DFCI TC1580129, TC1606400, TC1614372, TC1634373
DoTS DT.101725912, DT.55204109
NIA Mouse Gene Index U043385
Consensus CDS Project CCDS26888.1, CCDS56946.1
International Mouse Phenotyping Consortium Status Wnt5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021010 VEGA Gene Model | MGI Sequence Detail 22698 C57BL/6J ±  kb
transcript OTTMUST00000049665 VEGA | MGI Sequence Detail 7009 Not Applicable 
polypeptide OTTMUSP00000023050 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(12) UniProt(1)
Polymorphisms
RFLP(4) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR026538 Wnt-5a protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017445 protein Wnt-5a
References
(Earliest) J:10971 Gavin BJ, et al., Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec;4(12B):2319-32
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(364)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15443, MGD-MRK-15453, MGI:1924815

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory