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Wnt2
Gene Detail
Symbol

Name
ID
Wnt2
wingless-type MMTV integration site family, member 2
MGI:98954
STS
Synonyms
2610510E18Rik, Int1l1, Irp, m-irp, Mirp, Wnt-2, Wnt2a
Feature Type
protein coding gene
Genetic Map
Chromosome 6
8.08 cM, cytoband A2-A3.1
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr6:17988940-18030585 bp, - strand
From VEGA annotation of GRCm38

  41646 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt2

Human
homologs
Human Homolog WNT2, wingless-type MMTV integration site family member 2
NCBI Gene ID 7472
neXtProt AC  NX_P09544
Human Synonyms  INT1L1, IRP
Human Chr (Location)  7q31.2; chr7:117276631-117323289 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit impaired placental vascularization, runting and 50% perinatal mortality resulting from difficulties in breathing and nursing. Survivors of the perinatal period tend to recover, and adults are healthy and fertile.
 
Interactions
Wnt2 interacts with 255 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process atrial cardiac muscle tissue morphogenesis, canonical Wnt signaling pathway, ...
Component cytoplasm, extracellular matrix, ...
Function cytokine activity, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (783)    Tissues (447)    Images (80)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 668
Northern blot 37
RT-PCR 74
RNase protection 2
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(13) cDNA(24) Primer pair(13) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024176 (Evidence)
Ensembl Gene ModelENSMUSG00000010797 (Evidence)
Entrez Gene22413 (Evidence)
UniGene33653
DFCITC1586019
DoTSDT.60101196
NIA Mouse Gene IndexU027066
Consensus CDS ProjectCCDS19928.1
International Mouse Knockout Project StatusWnt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024176 VEGA Gene Model | MGI Sequence Detail 41646 C57BL/6J ±  kb
transcript OTTMUST00000059151 VEGA | MGI Sequence Detail 2255 Not Applicable 
polypeptide OTTMUSP00000028745 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(426 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009140 Wnt-2 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017440 protein Wnt-2
References
(Earliest) J:9380 Wainwright BJ, et al., Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 1988 Jun;7(6):1743-8
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(145)
Other
accession IDs
MGD-MRK-11475, MGD-MRK-15439, MGD-MRK-15449, MGI:1919406

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory