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Wnt2 Gene Detail
Summary
  • Symbol
    Wnt2
  • Name
    wingless-type MMTV integration site family, member 2
  • Synonyms
    2610510E18Rik, Int1l1, Irp, m-irp, Mirp, Wnt-2, Wnt2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98954
    NCBI Gene: 22413
  • Gene Overview
    MyGene.info: WNT2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:17988940-18030585 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 8.08 cM, cytoband A2-A3.1
  • Mapping Data
    15 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98954
protein coding gene Chr6:17985474-18032751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030473
protein coding gene Chr6:15268112-15311830 (-)
A/J MGP_AJ_G0030446
protein coding gene Chr6:14644473-14687337 (-)
AKR/J MGP_AKRJ_G0030373
protein coding gene Chr6:15150537-15195808 (-)
BALB/cJ MGP_BALBcJ_G0030455
protein coding gene Chr6:14739847-14781529 (-)
C3H/HeJ MGP_C3HHeJ_G0030169
protein coding gene Chr6:15025888-15072066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030910
protein coding gene Chr6:15745194-15790579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028121
protein coding gene Chr6:13590709-13632524 (-)
CAST/EiJ MGP_CASTEiJ_G0029571
protein coding gene Chr6:14935525-14976902 (-)
CBA/J MGP_CBAJ_G0030147
protein coding gene Chr6:16257103-16298530 (-)
DBA/2J MGP_DBA2J_G0030291
protein coding gene Chr6:14577522-14619066 (-)
FVB/NJ MGP_FVBNJ_G0030245
protein coding gene Chr6:14405722-14448534 (-)
LP/J MGP_LPJ_G0030378
protein coding gene Chr6:15368780-15421427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030281
protein coding gene Chr6:17410479-17455494 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030940
protein coding gene Chr6:15037401-15082065 (-)
PWK/PhJ MGP_PWKPhJ_G0029285
protein coding gene Chr6:14235096-14277377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029121
protein coding gene Chr6:14923598-14965080 (-)
WSB/EiJ MGP_WSBEiJ_G0029647
protein coding gene Chr6:14974977-15017296 (-)



Homology
more
  • Human Ortholog
    WNT2, Wnt family member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WNT2, Wnt family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INT1L1, IRP
  • Links
    NCBI Gene ID: 7472
    neXtProt AC: NX_P09544
    UniProt: P09544

  • Chr Location
    7q31.2; chr7:117276631-117323289 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit impaired placental vascularization, runting and 50% perinatal mortality resulting from difficulties in breathing and nursing. Survivors of the perinatal period tend to recover, and adults are healthy and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010797 Ensembl Gene Model | MGI Sequence Detail 41646 C57BL/6J ±  kb
    transcript ENSMUST00000010941 Ensembl | MGI Sequence Detail 2255 Not Applicable  
    polypeptide ENSMUSP00000010941 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 13
      cDNA 26
      Primer pair 16
      Other 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11475, MGD-MRK-15439, MGD-MRK-15449, MGI:1919406
    References
    more
    • Summaries
      All 175
      Developmental Gene Expression 122
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:9380 Wainwright BJ, et al., Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 1988 Jun;7(6):1743-8
    • Latest
      J:273296 Kaiser K, et al., WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Nat Commun. 2019 Apr 2;10(1):1498

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory