Wnt2
Gene Detail

Symbol Name ID

Wnt2 wingless-related MMTV integration site 2 MGI:98954

STS

D6Rck2

Synonyms

2610510E18Rik, Int1l1, Irp, m-irp, Mirp, Wnt-2, Wnt2a

Feature Type

protein coding gene

Genetic Map

Chromosome 6

8.08 cM, cytoband A2-A3.1
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr6:17988940-18030585 bp, - strand From VEGA annotation of GRCm38   41646 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20719  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt2

Human homologs

Human Homolog		WNT2, wingless-type MMTV integration site family member 2
NCBI Gene ID		7472
neXtProt AC		NX_P09544
Human Synonyms		INT1L1, IRP
Human Chr (Location)		7q31.2; chr7:116916685-116963343 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutants exhibit impaired placental vascularization, runting and 50% perinatal mortality resulting from difficulties in breathing and nursing. Survivors of the perinatal period tend to recover, and adults are healthy and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	atrial cardiac muscle tissue morphogenesis, canonical Wnt receptor signaling pathway, ...
Component	cytoplasm, extracellular matrix, ...
Function	cytokine activity, frizzled binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (78 records)
Data Summary: Results (441)    Tissues (236)    Images (72)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	320
Northern blot	37
RT-PCR	80
RNase protection	2

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) Genomic(13) cDNA(22) Primer pair(13) Other(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024176 (Evidence)
Ensembl Gene Model	ENSMUSG00000010797 (Evidence)
Entrez Gene	22413 (Evidence)
UniGene	33653
DFCI	TC1586019
DoTS	DT.60101196
NIA Mouse Gene Index	U027066
Consensus CDS Project	CCDS19928.1
International Mouse Knockout Project Status	Wnt2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024176	VEGA Gene Model | MGI Sequence Detail	41646	C57BL/6J
transcript	OTTMUST00000059151	VEGA | MGI Sequence Detail	2255	Not Applicable
polypeptide	OTTMUSP00000028745	VEGA | MGI Sequence Detail	360	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(241 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR009140	Wnt-2 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017440	protein Wnt-2

References

(Earliest) J:9380 Wainwright BJ, et al., Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. EMBO J. 1988 Jun;7(6):1743-8
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(129)

Other accession IDs

MGD-MRK-11475, MGD-MRK-15439, MGD-MRK-15449, MGI:1919406