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Wnt1 Gene Detail
Summary
  • Symbol
    Wnt1
  • Name
    wingless-type MMTV integration site family, member 1
  • Synonyms
    Int-1, Wnt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98953
    NCBI Gene: 22408
  • Gene Overview
    MyGene.info: WNT1
Location & Maps
more
  • Sequence Map
    Chr15:98789857-98793837 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3981 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WNT1, Wnt family member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT1, Wnt family member 1
    Orthology source: HomoloGene
  • Synonyms
    BMND16, INT1, OI15
  • Links
    NCBI Gene ID: 7471
    neXtProt AC: NX_P04628

  • Chr Location
    12q13; chr12:48978453-48982613 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Wnt1 mouse models; 1 with human WNT1 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480 View 2 models
       Osteogenesis Imperfecta, Type Xv; OI15   OMIM: 615220
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 7 alleles in 12 genetic backgrounds
    54 phenotypes from multigenic genotypes
    145 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    9
  • Transgenic
    2
  • Genomic Mutations
    3 involving Wnt1
  • Incidental Mutations
    APF , CvDC
In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020981 VEGA Gene Model | MGI Sequence Detail 3981 C57BL/6J ±  kb
transcript OTTMUST00000049616 VEGA | MGI Sequence Detail 2378 Not Applicable  
polypeptide OTTMUSP00000023019 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    Genomic 11
    cDNA 38
    Primer pair 13
    Other 41

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448
References
more
  • Summaries
    All 477
    Developmental Gene Expression 286
    Diseases 9
    Gene Ontology 56
    Phenotypes 145
  • Earliest
    J:15063 Lane PW, Swaying. Mouse News Lett. 1967;36:40
  • Latest
    J:228881 Gazea M, et al., Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory