Wnt1
Gene Detail

Symbol Name ID

Wnt1 wingless-related MMTV integration site 1 MGI:98953

Synonyms

Int-1, Wnt-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

54.65 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(50)

Sequence Map

Chr15:98789857-98793837 bp, + strand From VEGA annotation of GRCm38   3981 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt1

Human homologs

Human Homolog		WNT1, wingless-type MMTV integration site family, member 1
NCBI Gene ID		7471
neXtProt AC		NX_P04628
Human Synonyms		INT1
Human Chr (Location)		12q13; chr12:49372236-49376396 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.

 

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	BMP signaling pathway, branching involved in ureteric bud morphogenesis, ...
Component	cell surface, cytoplasm, ...
Function	cytokine activity, frizzled binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (259 records)
Data Summary: Results (909)    Tissues (343)    Images (212)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	641
Northern blot	103
RT-PCR	159
RNase protection	2

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(97) Genomic(11) cDNA(34) Primer pair(13) Other(39)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020981 (Evidence)
Ensembl Gene Model	ENSMUSG00000022997 (Evidence)
Entrez Gene	22408 (Evidence)
UniGene	1123
DFCI	TC1589053
DoTS	DT.40139855
NIA Mouse Gene Index	U016627
Consensus CDS Project	CCDS27807.1
International Mouse Knockout Project Status	Wnt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020981	VEGA Gene Model | MGI Sequence Detail	3981	C57BL/6J
transcript	OTTMUST00000049616	VEGA | MGI Sequence Detail	2378	Not Applicable
polypeptide	OTTMUSP00000023019	VEGA | MGI Sequence Detail	370	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(14) : PCR(2) RFLP(12) SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR009139	Wnt-1 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017435	proto-oncogene protein Wnt-1

References

(Earliest) J:15063 Lane PW, Swaying. Mouse News Lett. 1967;36:40
(Latest) J:194842 Yang J, et al., Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
All references(444)

Other accession IDs

MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448