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Wnt1
Gene Detail
Symbol

Name
ID
Wnt1
wingless-type MMTV integration site family, member 1
MGI:98953
Synonyms
Int-1, Wnt-1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.65 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr15:98789857-98793837 bp, + strand
From VEGA annotation of GRCm38

  3981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3963  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt1

Human
homologs
Human Homolog WNT1, wingless-type MMTV integration site family, member 1
NCBI Gene ID 7471
neXtProt AC  NX_P04628
Human Synonyms  BMND16, INT1, OI15
Human Chr (Location)  12q13; chr12:48978453-48982613 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human WNT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Radiation induced(1) Spontaneous(1) Targeted(7)
Genomic Mutations involving Wnt1 (1)
Incidental mutations (data from APF )
 
In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.
 
Interactions
Wnt1 interacts with 165 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process BMP signaling pathway, bone development, ...
Component cell surface, cytoplasm, ...
Function cytokine activity, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (276 records)
Data Summary: Results (1019)    Tissues (437)    Images (225)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 757
Northern blot 103
RT-PCR 153
RNase protection 2
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) Genomic(11) cDNA(38) Primer pair(13) Other(40)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020981 (Evidence)
Ensembl Gene ModelENSMUSG00000022997 (Evidence)
Entrez Gene22408 (Evidence)
UniGene1123
DFCITC1589053
DoTSDT.40139855
NIA Mouse Gene IndexU016627
Consensus CDS ProjectCCDS27807.1
International Mouse Knockout Project StatusWnt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020981 VEGA Gene Model | MGI Sequence Detail 3981 C57BL/6J ±  kb
transcript OTTMUST00000049616 VEGA | MGI Sequence Detail 2378 Not Applicable 
polypeptide OTTMUSP00000023019 VEGA | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(14) : PCR(2) RFLP(12) SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR009139 Wnt-1 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017435 proto-oncogene Wnt-1
References
(Earliest) J:15063 Lane PW, Swaying. Mouse News Lett. 1967;36:40
(Latest) J:210981 Joeng KS, et al., The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations. Hum Mol Genet. 2014 Aug 1;23(15):4035-42
All references(465)
Other
accession IDs
MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory