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Wnt1 Gene Detail
Summary
  • Symbol
    Wnt1
  • Name
    wingless-type MMTV integration site family, member 1
  • Synonyms
    Int-1, Wnt-1
Location &
Maps
more
  • Sequence Map
    Chr15:98687738-98691711 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.65 cM, cytoband F1-F3
  • Mapping Data
    50 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98953
 protein coding gene Chr15:98687738-98691718 (+)
129S1/SvImJ ENSMUSG00200046971
 protein coding gene Chr15:95875888-95879857 (+)
A/J ENSMUSG00195044076
 protein coding gene Chr15:95756558-95760549 (+)
AKR/J ENSMUSG00220045881
 protein coding gene Chr15:95761717-95765683 (+)
BALB/cJ ENSMUSG00180038835
 protein coding gene Chr15:95663227-95667209 (+)
C3H/HeJ ENSMUSG00175041242
 protein coding gene Chr15:95936694-95940685 (+)
C57BL/6NJ ENSMUSG00215049867
 protein coding gene Chr15:95725849-95729830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020246
 protein coding gene Chr15:92494560-92498536 (+)
CAST/EiJ ENSTCUG00005041257
 protein coding gene Chr15:95200244-95204195 (+)
CBA/J ENSMUSG00210028010
 protein coding gene Chr15:95721299-95725265 (+)
DBA/2J ENSMUSG00185035991
 protein coding gene Chr15:95756159-95760150 (+)
FVB/NJ ENSMUSG00205038023
 protein coding gene Chr15:95461260-95465237 (+)
JF1/MsJ ENSUMUG00000035290
 protein coding gene Chr15:95232818-95236781 (+)
LP/J ENSMUSG00230034188
 protein coding gene Chr15:99099618-99103587 (+)
NOD/ShiLtJ ENSMUSG00190025077
 protein coding gene Chr15:95740936-95744916 (+)
NZO/HlLtJ ENSMUSG00225041632
 protein coding gene Chr15:99362849-99366828 (+)
PWK/PhJ ENSLUMG00010037039
 protein coding gene Chr15:95431907-95435885 (+)
SPRET/EiJ ENSMSPG00010049054
 protein coding gene Chr15:97253018-97256987 (+)
WSB/EiJ ENSIUOG00005037576
 protein coding gene Chr15:95853431-95857423 (+)



Homology
more
  • Human Ortholog
    WNT1, Wnt family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT1, Wnt family member 1
  • Synonyms
    BMND16, INT1, OI15
  • Links
    NCBI Gene ID: 7471
    UniProt: P04628

  • Chr Location
    12q13.12; chr12:48978322-48982620 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wnt1 mouse models; 1 with human WNT1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 8 alleles in 14 genetic backgrounds
    58 phenotypes from multigenic genotypes
    221 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In mild form, homozygotes have ataxia and hypertonia, with malformation of anterior cerebellum, deep midline fissure, and impaired fertility. In the severe form, there is virtually no midbrain and cerebellum and mutants die within hours of birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    132
  • GO References
    60
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1900
  • Tissues
    500
  • cDNA Data
    45
  • Literature Summary
    356
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22408 NCBI Gene Model | MGI Sequence Detail 3974 C57BL/6J ±  kb
    transcript NM_021279 RefSeq | MGI Sequence Detail 2371 ZRU/MplStud  
    polypeptide P04426 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      Genomic 11
      cDNA 51
      Primer pair 26
      Other 65
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11418, MGD-MRK-14669, MGD-MRK-15438, MGD-MRK-15448
    References
    more
    • Summaries
      All 940
      Developmental Gene Expression 356
      Diseases 4
      Gene Ontology 60
      Phenotypes 221
    • Earliest
      J:6976 Nusse R, et al., Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 1982 Nov;31(1):99-109
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory