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Vav1 Gene Detail
Summary
  • Symbol
    Vav1
  • Name
    vav 1 oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:98923
    NCBI Gene: 22324
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57586100-57635031 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.76 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98923
protein coding gene Chr17:57586080-57636236 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023962
protein coding gene Chr17:59059032-59116375 (+)
A/J MGP_AJ_G0023920
protein coding gene Chr17:57411726-57460482 (+)
AKR/J MGP_AKRJ_G0023889
protein coding gene Chr17:58138545-58189680 (+)
BALB/cJ MGP_BALBcJ_G0023921
protein coding gene Chr17:57248418-57298997 (+)
C3H/HeJ MGP_C3HHeJ_G0023685
protein coding gene Chr17:58854980-58906913 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024367
protein coding gene Chr17:61352794-61406541 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021813
protein coding gene Chr17:53876708-53926647 (+)
CAST/EiJ MGP_CASTEiJ_G0023167
protein coding gene Chr17:59166364-59224601 (+)
CBA/J MGP_CBAJ_G0023661
protein coding gene Chr17:63753275-63807838 (+)
DBA/2J MGP_DBA2J_G0023789
protein coding gene Chr17:56101176-56150299 (+)
FVB/NJ MGP_FVBNJ_G0023755
protein coding gene Chr17:55680926-55730588 (+)
LP/J MGP_LPJ_G0023871
protein coding gene Chr17:59735810-59790045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023783
protein coding gene Chr17:63169517-63221426 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024411
protein coding gene Chr17:58501085-58551093 (+)
PWK/PhJ MGP_PWKPhJ_G0022913
protein coding gene Chr17:55473249-55524452 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022724
protein coding gene Chr17:55275697-55332657 (+)
WSB/EiJ MGP_WSBEiJ_G0023233
protein coding gene Chr17:59140174-59194240 (+)



Homology
more
  • Human Ortholog
    VAV1, vav guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAV1, vav guanine nucleotide exchange factor 1
  • Synonyms
    VAV
  • Links
    NCBI Gene ID: 7409
    neXtProt AC: NX_P15498
    UniProt: P15498

  • Chr Location
    19p13.3; chr19:6772708-6857366 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 12 alleles in 18 genetic backgrounds
    50 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit defective T cell maturation, interleukin-2 production, and cell cycle progression. Immunoglobulin class switching is also impaired and attributed to defective T cell help.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034116 Ensembl Gene Model | MGI Sequence Detail 48932 C57BL/6J ±  kb
    transcript ENSMUST00000005889 Ensembl | MGI Sequence Detail 2963 Not Applicable  
    polypeptide ENSMUSP00000005889 Ensembl | MGI Sequence Detail 845 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 46
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15381
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 118
    • Earliest
      J:18384 Katzav S, et al., vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989 Aug;8(8):2283-90
    • Latest
      J:325006 Cortes JR, et al., Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma. Cell Rep. 2022 Apr 19;39(3):110695

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory