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Vav1
Gene Detail
Symbol

Name
ID
Vav1
vav 1 oncogene
MGI:98923
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr17:57279100-57328031 bp, + strand
From VEGA annotation of GRCm38

  48932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3961  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: vav transforming protein
Gene Tree: Vav1

Human
homologs
Human Homolog VAV1, vav 1 guanine nucleotide exchange factor
NCBI Gene ID 7409
neXtProt AC  NX_P15498
Human Synonyms  VAV
Human Chr (Location)  19p13.2; chr19:6772668-6857366 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants exhibit defective T cell maturation, interleukin-2 production, and cell cycle progression. Immunoglobulin class switching is also impaired and attributed to defective T cell help.
 
Interactions
Vav1 interacts with 69 markers (Mir24-1, Mir24-2, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process G-protein coupled receptor signaling pathway, immune response, ...
Component cell-cell junction, intracellular
Function guanyl-nucleotide exchange factor activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (76)    Tissues (26)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 51
RT-PCR 21
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036994 (Evidence)
Ensembl Gene ModelENSMUSG00000034116 (Evidence)
Entrez Gene22324 (Evidence)
UniGene248172
DFCITC1575273, TC1594756, TC1596173, TC1660670
DoTSDT.101347811, DT.101380638, DT.101380639, DT.110559645, DT.97366427, DT.99863524
NIA Mouse Gene IndexU018150
PDB1F5X, 1GCP, 1GCQ, 1K1Z, 2KBT, 2VRW
Consensus CDS ProjectCCDS28931.1, CCDS50158.1, CCDS50159.1
International Mouse Knockout Project StatusVav1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036994 VEGA Gene Model | MGI Sequence Detail 48932 C57BL/6J ±  kb
transcript OTTMUST00000095128 VEGA | MGI Sequence Detail 2963 Not Applicable 
polypeptide OTTMUSP00000053044 VEGA | MGI Sequence Detail 845 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(7) UniProt(27)
Polymorphisms
RFLP(6) : SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR003096 Smooth muscle protein/calponin
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000003118 proto-oncogene vav
References
(Earliest) J:18384 Katzav S, et al., vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989 Aug;8(8):2283-90
(Latest) J:209904 Zenker S, et al., A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6. J Immunol. 2014 Mar 15;192(6):2830-6
All references(169)
Other
accession IDs
MGD-MRK-15381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory