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Ucp1 Gene Detail
Summary
  • Symbol
    Ucp1
  • Name
    uncoupling protein 1 (mitochondrial, proton carrier)
  • Synonyms
    Slc25a7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98894
    NCBI Gene: 22227
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84016981-84025081 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 39.65 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98894
protein coding gene Chr8:84016977-84025085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033828
protein coding gene Chr8:84081861-84094164 (+)
A/J MGP_AJ_G0033811
protein coding gene Chr8:80794854-80802920 (+)
AKR/J MGP_AKRJ_G0033737
protein coding gene Chr8:83178358-83186415 (+)
BALB/cJ MGP_BALBcJ_G0033804
protein coding gene Chr8:80914004-80922034 (+)
C3H/HeJ MGP_C3HHeJ_G0033513
protein coding gene Chr8:83811535-83819571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034324
protein coding gene Chr8:87337261-87345379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031265
protein coding gene Chr8:74639332-74647463 (+)
CAST/EiJ MGP_CASTEiJ_G0032844
protein coding gene Chr8:83209274-83217296 (+)
CBA/J MGP_CBAJ_G0033492
protein coding gene Chr8:90434028-90442072 (+)
DBA/2J MGP_DBA2J_G0033645
protein coding gene Chr8:80439730-80447758 (+)
FVB/NJ MGP_FVBNJ_G0033590
protein coding gene Chr8:79375173-79383228 (+)
LP/J MGP_LPJ_G0033735
protein coding gene Chr8:84214607-84222647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033633
protein coding gene Chr8:92957153-92965507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034341
protein coding gene Chr8:83190453-83201523 (+)
PWK/PhJ MGP_PWKPhJ_G0032547
protein coding gene Chr8:79671347-79679704 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032385
protein coding gene Chr8:81989188-81996681 (+)
WSB/EiJ MGP_WSBEiJ_G0032957
protein coding gene Chr8:83573195-83581242 (+)



Homology
more
  • Human Ortholog
    UCP1, uncoupling protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCP1, uncoupling protein 1
  • Synonyms
    SLC25A7, UCP
  • Links
    NCBI Gene ID: 7350
    neXtProt AC: NX_P25874
    UniProt: P25874

  • Chr Location
    4q31.1; chr4:140559431-140568961 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human UCP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired thermoregulation on some genetic backgrounds. Biochemical alterations in brown fat mitochondria are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031710 Ensembl Gene Model | MGI Sequence Detail 8101 C57BL/6J ±  kb
    transcript ENSMUST00000034146 Ensembl | MGI Sequence Detail 1636 Not Applicable  
    polypeptide ENSMUSP00000034146 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 36
      Primer pair 17
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15339, MGI:2142517
    References
    more
    • Summaries
      All 428
      Developmental Gene Expression 81
      Gene Ontology 20
      Phenotypes 196
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345694 Stanic S, et al., Prolonged FGF21 treatment increases energy expenditure and induces weight loss in obese mice independently of UCP1 and adrenergic signaling. Biochem Pharmacol. 2024 Feb 6;221:116042

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory