Ucp1
Gene Detail

Symbol Name ID

Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) MGI:98894

Synonyms

Slc25a7

Feature Type

protein coding gene

Genetic Map

Chromosome 8

39.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)

Sequence Map

Chr8:83290348-83298456 bp, + strand From NCBI annotation of GRCm38   8109 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ucp1

Human homologs

Human Homolog		UCP1, uncoupling protein 1 (mitochondrial, proton carrier)
NCBI Gene ID		7350
neXtProt AC		NX_P25874
Human Synonyms		SLC25A7, UCP
Human Chr (Location)		4q28-q31; chr4:141481050-141489959 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UCP1

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Homozygous null mutants exhibit impaired thermoregulation on some genetic backgrounds. Biochemical alterations in brown fat mitochondria are also observed.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	mitochondrial transport, proton transport, ...
Component	integral to membrane, membrane, ...
Function	oxidative phosphorylation uncoupler activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (35)    Tissues (5)    Images (3)
Theiler Stages: 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	21
RT-PCR	13

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(1) cDNA(35) Primer pair(5) Other(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000031710 (Evidence)
Entrez Gene	22227 (Evidence)
UniGene	4177
DFCI	TC1581921, TC1668179, TC1759661
DoTS	DT.491267, DT.50315045
NIA Mouse Gene Index	U009550
Consensus CDS Project	CCDS22449.1
International Mouse Knockout Project Status	Ucp1

Sequences

Length	Strain/Species
genomic	22227	NCBI Gene Model | MGI Sequence Detail	8109	C57BL/6J
transcript	NM_009463	RefSeq | MGI Sequence Detail	1644	C57BL/6
polypeptide	P12242	UniProt | EBI | MGI Sequence Detail	307	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs(78 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002030	Mitochondrial brown fat uncoupling protein
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000017035	mitochondrial brown fat uncoupling protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:8101 Jacobsson A, et al., Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem. 1985 Dec 25;260(30):16250-4
(Latest) J:193353 Borensztein M, et al., Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression. FASEB J. 2012 Nov;26(11):4584-91
All references(142)

Other accession IDs

MGD-MRK-15339, MGI:2142517