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Ucp1 Gene Detail
Summary
  • Symbol
    Ucp1
  • Name
    uncoupling protein 1 (mitochondrial, proton carrier)
  • Synonyms
    Slc25a7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98894
    NCBI Gene: 22227
  • Gene Overview
    MyGene.info: UCP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:83290352-83298452 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8101 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 39.65 cM
  • Mapping Data
    35 experiments
Homology
more
  • Human Ortholog
    UCP1, uncoupling protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UCP1, uncoupling protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLC25A7, UCP
  • Links
    NCBI Gene ID: 7350
    neXtProt AC: NX_P25874
    UniProt: P25874

  • Chr Location
    4q31.1; chr4:140555770-140568914 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human UCP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired thermoregulation on some genetic backgrounds. Biochemical alterations in brown fat mitochondria are also observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061515 VEGA Gene Model | MGI Sequence Detail 8101 C57BL/6J ±  kb
    transcript OTTMUST00000150074 VEGA | MGI Sequence Detail 1636 Not Applicable  
    polypeptide OTTMUSP00000077810 VEGA | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      113 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 35
      Primer pair 6
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15339, MGI:2142517
    References
    more
    • Summaries
      All 289
      Developmental Gene Expression 42
      Gene Ontology 18
      Phenotypes 114
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:261351 Schilperoort M, et al., The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018 Jan 17;None(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory