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Ucp1
Gene Detail
 Symbol
Name
ID
Ucp1
uncoupling protein 1 (mitochondrial, proton carrier)
MGI:98894
Synonyms Slc25a7
Feature Type protein coding gene
Genetic Map
Chromosome 8
39.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(35)
Sequence Map
Chr8:83290348-83298456 bp, + strand
From NCBI annotation of GRCm38

  8109 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ucp1

Human
homologs
Human Homolog UCP1, uncoupling protein 1 (mitochondrial, proton carrier)
NCBI Gene ID 7350
neXtProt AC  NX_P25874
Human Synonyms  SLC25A7, UCP
Human Chr (Location)  4q28-q31; chr4:140559860-140568835 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human UCP1
Alleles
and
phenotypes
All alleles(3) : Targeted(2) Spontaneous(1)
 
Homozygous null mutants exhibit impaired thermoregulation on some genetic backgrounds. Biochemical alterations in brown fat mitochondria are also observed.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process mitochondrial transport, proton transport, ...
Component integral component of membrane, membrane, ...
Function oxidative phosphorylation uncoupler activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (35)    Tissues (5)    Images (3)
Theiler Stages: 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 1
Northern blot 21
RT-PCR 13
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) Genomic(1) cDNA(35) Primer pair(5) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031710 (Evidence)
Entrez Gene22227 (Evidence)
UniGene4177
DFCITC1581921, TC1668179, TC1759661
DoTSDT.491267, DT.50315045
NIA Mouse Gene IndexU009550
Consensus CDS ProjectCCDS22449.1
International Mouse Knockout Project StatusUcp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22227 NCBI Gene Model | MGI Sequence Detail 8109 C57BL/6J ±  kb
transcript NM_009463 RefSeq | MGI Sequence Detail 1644 C57BL/6 
polypeptide P12242 UniProt | EBI | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000017035 mitochondrial brown fat uncoupling protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:8101 Jacobsson A, et al., Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem. 1985 Dec 25;260(30):16250-4
(Latest) J:206840 Shabalina IG, et al., UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep. 2013 Dec 12;5(5):1196-203
All references(149)
Other
accession IDs
MGD-MRK-15339, MGI:2142517

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory