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Uba1 Gene Detail
Summary
  • Symbol
    Uba1
  • Name
    ubiquitin-like modifier activating enzyme 1
  • Synonyms
    A1S9, Sbx, Ube-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98890
    NCBI Gene: 22201
  • Gene Overview
    MyGene.info: UBA1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20658326-20683179 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.15 cM, cytoband A2-A3
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98890
protein coding gene ChrX:20658302-20683179 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035594
protein coding gene ChrX:15546477-15570585 (+)
A/J MGP_AJ_G0035571
protein coding gene ChrX:15636561-15661429 (+)
AKR/J MGP_AKRJ_G0035504
protein coding gene ChrX:16177724-16205587 (+)
BALB/cJ MGP_BALBcJ_G0035564
protein coding gene ChrX:15383062-15407411 (+)
C3H/HeJ MGP_C3HHeJ_G0035282
protein coding gene ChrX:15767144-15792306 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036100
protein coding gene ChrX:15957902-15981678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032964
protein coding gene ChrX:13887698-13910981 (+)
CAST/EiJ MGP_CASTEiJ_G0034573
protein coding gene ChrX:15060106-15084268 (+)
CBA/J MGP_CBAJ_G0035251
protein coding gene ChrX:16692043-16717247 (+)
DBA/2J MGP_DBA2J_G0035403
protein coding gene ChrX:15438988-15464088 (+)
FVB/NJ MGP_FVBNJ_G0035349
protein coding gene ChrX:15341042-15365076 (+)
LP/J MGP_LPJ_G0035485
protein coding gene ChrX:15796171-15822552 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035393
protein coding gene ChrX:16948308-16973240 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036107
protein coding gene ChrX:15460585-15488908 (+)
PWK/PhJ MGP_PWKPhJ_G0034274
protein coding gene ChrX:14626395-14651858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034114
protein coding gene ChrX:15444268-15470557 (+)
WSB/EiJ MGP_WSBEiJ_G0034708
protein coding gene ChrX:15328737-15354717 (+)



Homology
more
  • Human Ortholog
    UBA1, ubiquitin like modifier activating enzyme 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UBA1, ubiquitin like modifier activating enzyme 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
  • Links
    NCBI Gene ID: 7317
    neXtProt AC: NX_P22314
    UniProt: P22314

  • Chr Location
    Xp11.3; chrX:47190800-47215128 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001924 Ensembl Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
transcript ENSMUST00000089217 Ensembl | MGI Sequence Detail 4044 Not Applicable  
polypeptide ENSMUSP00000086626 Ensembl | MGI Sequence Detail 1058 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016950 ubiquitin-like modifier-activating enzyme 1
  • PDB
  • EC
  • InterPro Domains
    IPR000594 THIF-type NAD/FAD binding fold
    IPR035985 Ubiquitin-activating enzyme
    IPR019572 Ubiquitin-activating enzyme, catalytic cysteine domain
    IPR018075 Ubiquitin-activating enzyme E1
    IPR018074 Ubiquitin-activating enzyme E1, conserved site
    IPR018965 Ubiquitin-activating enzyme E1, C-terminal
    IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily
    IPR033127 Ubiquitin-activating enzyme E1, Cys active site
    IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
    IPR042302 Ubiquitin-activating enzyme E1, FCCH domain superfamily
    IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
    IPR042449 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
    IPR042063 Ubiquitin-activating enzyme E1, SCCH domain
    IPR000011 Ubiquitin/SUMO-activating enzyme E1
Molecular
Reagents
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  • All nucleic 731
    Genomic 1
    cDNA 726
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1003, MGD-MRK-14297, MGD-MRK-15328, MGD-MRK-15331, MGI:2147838
References
more
  • Summaries
    All 60
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:615 Kay GF, et al., A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Nature. 1991 Dec 12;354(6353):486-9
  • Latest
    J:212083 Wade BE, et al., Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. J Neurosci. 2014 Jun 18;34(25):8411-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory