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Uba1 Gene Detail
Summary
  • Symbol
    Uba1
  • Name
    ubiquitin-like modifier activating enzyme 1
  • Synonyms
    A1S9, Sbx, Ube-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98890
    NCBI Gene: 22201
Location & Maps
more
  • Sequence Map
    ChrX:20658326-20683179 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24854 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UBA1, ubiquitin like modifier activating enzyme 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UBA1, ubiquitin like modifier activating enzyme 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
  • Links
    NCBI Gene ID: 7317
    neXtProt AC: NX_P22314

  • Chr Location
    Xp11.23; chrX:47190800-47215128 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human UBA1 associations

Human Disease Mouse Models
       Spinal Muscular Atrophy, X-Linked 2; SMAX2   OMIM: 301830
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    5
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017113 VEGA Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
transcript OTTMUST00000041440 VEGA | MGI Sequence Detail 4044 Not Applicable  
polypeptide OTTMUSP00000018598 VEGA | MGI Sequence Detail 1058 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016950 ubiquitin-like modifier-activating enzyme 1
  • PDB
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR000594 THIF-type NAD/FAD binding fold
    IPR019572 Ubiquitin-activating enzyme, catalytic cysteine domain
    IPR018075 Ubiquitin-activating enzyme E1
    IPR018074 Ubiquitin-activating enzyme, E1, active site
    IPR018965 Ubiquitin-activating enzyme E1, C-terminal
    IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
    IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
    IPR000011 Ubiquitin/SUMO-activating enzyme E1
Molecular
Reagents
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  • All nucleic 730
    Genomic 1
    cDNA 725
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1003, MGD-MRK-14297, MGD-MRK-15328, MGD-MRK-15331, MGI:2147838
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:615 Kay GF, et al., A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Nature. 1991 Dec 12;354(6353):486-9
  • Latest
    J:211929 Chen C, et al., Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IkappaBa/NF-kappaB and MKP1/ERK/STAT1 pathways. Immunology. 2014 Jun;142(2):307-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory