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Uba1
Gene Detail
 Symbol
Name
ID
Uba1
ubiquitin-like modifier activating enzyme 1
MGI:98890
Synonyms A1S9, Sbx, Ube-1
Feature Type protein coding gene
Genetic Map
Chromosome X
16.15 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
ChrX:20658326-20683179 bp, + strand
From VEGA annotation of GRCm38

  24854 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Uba1

Human
homologs
Human Homolog UBA1, ubiquitin-like modifier activating enzyme 1
NCBI Gene ID 7317
neXtProt AC  NX_P22314
Human Synonyms  A1S9, A1S9T, A1ST, AMCX1, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
Human Chr (Location)  Xp11.23; chrX:47190800-47215128 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human UBA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from APF )
Interactions
Uba1 interacts with 136 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular protein modification process, cellular response to DNA damage stimulus, ...
Component cytoplasm, cytosol, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (54)    Tissues (10)    Images (6)
Theiler Stages: 21, 22, 24, 26, 28
Assay TypeResults
Northern blot 24
RT-PCR 20
RNase protection 10
cDNA source data(722)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(730) Genomic(1) cDNA(725) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017113 (Evidence)
Ensembl Gene ModelENSMUSG00000001924 (Evidence)
Entrez Gene22201 (Evidence)
UniGene1104
DFCITC1573754, TC1611999, TC1673601, TC1706711, TC1722687, TC1770594, TC1780556
DoTSDT.101250639, DT.101329283, DT.101720455, DT.102540151, DT.111019412, DT.111019426, DT.111019439, DT.87070120, DT.94251983, DT.94251985, DT.99869248, DT.99869483
NIA Mouse Gene IndexU019749
PDB1Z7L, 2LZJ, 2V31
Consensus CDS ProjectCCDS30044.1
International Mouse Knockout Project StatusUba1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017113 VEGA Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
transcript OTTMUST00000041440 VEGA | MGI Sequence Detail 4044 Not Applicable 
polypeptide OTTMUSP00000018598 VEGA | MGI Sequence Detail 1058 Not Applicable 

For the selected sequences
All sequences(147) RefSeq(8) UniProt(2)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR019572 Ubiquitin-activating enzyme
InterPro IPR018075 Ubiquitin-activating enzyme, E1
InterPro IPR018074 Ubiquitin-activating enzyme, E1, active site
InterPro IPR018965 Ubiquitin-activating enzyme e1, C-terminal
InterPro IPR000127 Ubiquitin-activating enzyme repeat
InterPro IPR023280 Ubiquitin-like 1 activating enzyme, catalytic cysteine domain
InterPro IPR000011 Ubiquitin/SUMO-activating enzyme E1
Protein Ontology PR:000016950 ubiquitin-like modifier-activating enzyme 1
References (Earliest) J:615 Kay GF, et al., A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1. Nature. 1991 Dec 12;354(6353):486-9
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(56)
Other
accession IDs
MGD-MRK-1003, MGD-MRK-14297, MGD-MRK-15328, MGD-MRK-15331, MGI:2147838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory