Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle and desmosome. Is expressed in adrenal gland; brain; gonad; liver; and lung. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1).