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Prss1
Gene Detail
Symbol

Name
ID
Prss1
protease, serine 1 (trypsin 1)
MGI:98839
Synonyms
PRSS1, Try1, Try-1, Trygn16
Feature Type
protein coding gene
Genetic Map
Chromosome 6
19.60 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:41458932-41463786 bp, + strand
From VEGA annotation of GRCm38

  4855 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88408  Vertebrate Homology Class
4 mouse; 5 rat

Protein SuperFamily: trypsin
Gene Tree: Prss1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
Human Diseases Modeled in Mice Using Prss1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Prss1 interacts with 10 markers (Mir205, Mir325, Mir342, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process digestion, proteolysis
Component extracellular space
Function serine-type endopeptidase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (1)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
cDNA source data(1)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase LOC496697, prss1    NEW 
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000026897 (Evidence)
Ensembl Gene Model ENSMUSG00000062751 (Evidence)
Entrez Gene 114228 (Evidence)
EC 3.4.21.4
Consensus CDS Project CCDS20049.1
International Mouse Phenotyping Consortium Status Prss1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026897 VEGA Gene Model | MGI Sequence Detail 4855 C57BL/6J ±  kb
transcript OTTMUST00000066517 VEGA | MGI Sequence Detail 805 Not Applicable 
polypeptide OTTMUSP00000033342 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(3) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(56 from dbSNP Build 137)    SNPs within 2kb including multiple locations(96)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
References
(Earliest) J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(23)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15253, MGD-MRK-15254, MGI:2148749

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory