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Prss1 Gene Detail
Summary
  • Symbol
    Prss1
  • Name
    protease, serine 1 (trypsin 1)
  • Synonyms
    PRSS1, Try1, Try-1, Trygn16
  • Feature Type
    protein coding gene
  • IDs
    MGI:98839
    NCBI Gene: 114228
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41458932-41463786 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 19.60 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    11
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98839
protein coding gene Chr6:41458930-41463786 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030626
protein coding gene Chr6:39902791-39904543 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0030323
protein coding gene Chr6:39424240-39499587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031065
protein coding gene Chr6:40953984-40975892 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029727
protein coding gene Chr6:39260752-39262096 (-)
CBA/J MGP_CBAJ_G0030300
protein coding gene Chr6:42568502-42583228 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0030397
protein coding gene Chr6:37710532-37716073 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031095
protein coding gene Chr6:39344780-39354511 (+)
PWK/PhJ MGP_PWKPhJ_G0029440
protein coding gene Chr6:37577739-37583359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029277
protein coding gene Chr6:39048046-39052013 (+)
WSB/EiJ MGP_WSBEiJ_G0029803
protein coding gene Chr6:39250181-39253165 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062751 Ensembl Gene Model | MGI Sequence Detail 4855 C57BL/6J ±  kb
    transcript ENSMUST00000031910 Ensembl | MGI Sequence Detail 805 Not Applicable  
    polypeptide ENSMUSP00000031910 Ensembl | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15253, MGD-MRK-15254, MGI:2148749
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory