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Tpm1
Gene Detail
Symbol

Name
ID
Tpm1
tropomyosin 1, alpha
MGI:98809
Synonyms
alpha-TM, TM2, Tm3, Tpm-1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
36.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:67022590-67049406 bp, - strand
From VEGA annotation of GRCm38

  26817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128637  Vertebrate Homology Class
1 mouse; 1 rat; 1 dog; 1 zebrafish

HCOP human homology predictions: TPM1
Gene Tree: Tpm1

Human
homologs
TPM1, tropomyosin 1 (alpha)
Orthology source: HGNC

IDs:
NCBI Gene ID: 7168
neXtProt AC: NX_P09493

Human Synonyms: C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA

Human Chr (Location): 15q22.1; chr15:63042639-63071915 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TPM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display embryonic lethality.
 
Interactions
Tpm1 interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin filament capping, cardiac muscle contraction, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (338)    Tissues (39)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 321
Northern blot 10
Western blot 7
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tpm1    NEW 
Molecular
reagents
All nucleic(32) Genomic(2) cDNA(28) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000020411 (Evidence)
Ensembl Gene Model ENSMUSG00000032366 (Evidence)
Entrez Gene 22003 (Evidence)
DFCI TC1573264, TC1575333, TC1585938, TC1588054, TC1624389, TC1657454
NIA Mouse Gene Index U031028
Consensus CDS Project CCDS23311.1, CCDS52841.1, CCDS52842.1, CCDS52843.1, CCDS52844.1, CCDS52845.1, CCDS52846.1, CCDS52847.1, CCDS52848.1
International Mouse Phenotyping Consortium Status Tpm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020411 VEGA Gene Model | MGI Sequence Detail 26817 C57BL/6J ±  kb
transcript OTTMUST00000048453 VEGA | MGI Sequence Detail 1824 Not Applicable 
polypeptide OTTMUSP00000022211 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(190) RefSeq(50) UniProt(20)
Polymorphisms
RFLP(1) : SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000533 Tropomyosin
Protein Ontology PR:000016579 tropomyosin alpha-1 chain
References
(Earliest) J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
(Latest) J:211921 McKeown CR, et al., Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn. 2014 Jun;243(6):800-17
All references(80)
Other
accession IDs
MGD-MRK-15202, MGD-MRK-15205, MGI:2142971, MGI:2143162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory