Tpm1
Gene Detail

Symbol Name ID

Tpm1 tropomyosin 1, alpha MGI:98809

Synonyms

alpha-TM, TM2, Tm3, Tpm-1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

36.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr9:67022590-67049406 bp, - strand From VEGA annotation of GRCm38   26817 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128637  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 zebrafish

Gene Tree: Tpm1

Alleles and phenotypes

All alleles(18) : Targeted(5) Gene trapped(13)
 

Mice homozygous for disruptions in this gene display embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	actin filament capping, cardiac muscle contraction, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, actin filament binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (338)    Tissues (39)    Images (25)
Theiler Stages: 13, 21, 22, 23, 28

Assay Type	Results
RNA in situ	321
Northern blot	10
Western blot	7

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(2) cDNA(28) Primer pair(1) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020411 (Evidence)
Ensembl Gene Model	ENSMUSG00000032366 (Evidence)
Entrez Gene	22003 (Evidence)
DFCI	TC1573264, TC1575333, TC1585938, TC1588054, TC1624389, TC1657454
NIA Mouse Gene Index	U031028
Consensus CDS Project	CCDS23311.1, CCDS52841.1, CCDS52842.1, CCDS52843.1, CCDS52844.1, CCDS52845.1, CCDS52846.1, CCDS52847.1, CCDS52848.1
International Mouse Knockout Project Status	Tpm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020411	VEGA Gene Model | MGI Sequence Detail	26817	C57BL/6J
transcript	OTTMUST00000048453	VEGA | MGI Sequence Detail	1824	Not Applicable
polypeptide	OTTMUSP00000022211	VEGA | MGI Sequence Detail	326	Not Applicable

All sequences(156) RefSeq(20) UniProt(21)

Polymorphisms

RFLP(1) : SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000533	Tropomyosin
Protein Ontology	PR:000016579	tropomyosin alpha-1 chain

References

(Earliest) J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(77)

Other accession IDs

MGD-MRK-15202, MGD-MRK-15205, MGI:2142971, MGI:2143162