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Tpm1 Gene Detail
Summary
  • Symbol
    Tpm1
  • Name
    tropomyosin 1, alpha
  • Synonyms
    alpha-TM, TM2, Tm3, Tpm-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98809
    NCBI Gene: 22003
  • Gene Overview
    MyGene.info: TPM1
Location & Maps
more
  • Sequence Map
    Chr9:67022590-67049406 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26817 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 36.27 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    TPM1, tropomyosin 1 (alpha)
  • Vertebrate Orthologs
    4
  • Human Ortholog
    TPM1, tropomyosin 1 (alpha)
    Orthology source: HGNC
  • Synonyms
    C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA
  • Links
    NCBI Gene ID: 7168
    neXtProt AC: NX_P09493

  • Chr Location
    15q22.2; chr15:63042639-63071915 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tpm1 mouse models; 2 with human TPM1 associations

Human Disease Mouse Models
       Cardiomyopathy, Familial Hypertrophic, 3; CMH3   OMIM: 115196 View 1 model
       Cardiomyopathy, Dilated, 1y; CMD1Y   OMIM: 611878
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Targeted
    5
  • Transgenic
    2
  • Genomic Mutations
    1 involving Tpm1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020411 VEGA Gene Model | MGI Sequence Detail 26817 C57BL/6J ±  kb
transcript OTTMUST00000048453 VEGA | MGI Sequence Detail 1824 Not Applicable  
polypeptide OTTMUSP00000022211 VEGA | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    147 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 2
    cDNA 28
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-15202, MGD-MRK-15205, MGI:2142971, MGI:2143162
References
more
  • Summaries
    All 81
    Developmental Gene Expression 23
    Diseases 6
    Gene Ontology 9
    Phenotypes 25
  • Earliest
    J:9738 Takenaga K, et al., Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2. Mol Cell Biol. 1988 Dec;8(12):5561-5
  • Latest
    J:229890 Ang SY, et al., KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1;143(5):810-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory