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Top2b
Gene Detail
Symbol

Name
ID
Top2b
topoisomerase (DNA) II beta
MGI:98791
Synonyms
D230016L12Rik, Top-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:16365179-16430787 bp, + strand
From VEGA annotation of GRCm38

  65609 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134711  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: type II DNA topoisomerase
Gene Tree: Top2b

Human
homologs
Human Homolog TOP2B, topoisomerase (DNA) II beta 180kDa
NCBI Gene ID 7155
neXtProt AC  NX_Q02880
Human Synonyms  top2beta, TOPIIB
Human Chr (Location)  3p24; chr3:25597905-25664905 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.
 
Interactions
Top2b interacts with 137 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ATP catabolic process, axonogenesis, ...
Component cytoplasm, cytosol, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (64)    Tissues (60)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 54
cDNA source data(270)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(278) cDNA(277) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035016 (Evidence)
Ensembl Gene ModelENSMUSG00000017485 (Evidence)
Entrez Gene21974 (Evidence)
UniGene130362
DFCITC1572298, TC1617046
EC5.99.1.3
Consensus CDS ProjectCCDS26833.1
International Mouse Knockout Project StatusTop2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035016 VEGA Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
transcript OTTMUST00000089034 VEGA | MGI Sequence Detail 5660 Not Applicable 
polypeptide OTTMUSP00000048601 VEGA | MGI Sequence Detail 1612 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(320 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024946 Arginine repressor C-terminal-like domain
InterPro IPR001241 DNA topoisomerase, type IIA
InterPro IPR013759 DNA topoisomerase, type IIA, central domain
InterPro IPR018522 DNA topoisomerase, type IIA, conserved site
InterPro IPR013760 DNA topoisomerase, type IIA-like domain
InterPro IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
InterPro IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
InterPro IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
InterPro IPR012542 DTHCT
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
InterPro IPR006171 Toprim domain
InterPro IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain
Protein Ontology PR:000016545 DNA topoisomerase 2-beta
References
(Earliest) J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
(Latest) J:207483 Li Y, et al., Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3(2):172-84
All references(52)
Other
accession IDs
MGD-MRK-15166, MGD-MRK-15170, MGI:2441960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory