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Top2b Gene Detail
Summary
  • Symbol
    Top2b
  • Name
    topoisomerase (DNA) II beta
  • Synonyms
    D230016L12Rik, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98791
    NCBI Gene: 21974
  • Gene Overview
    MyGene.info: TOP2B
Location & Maps
more
  • Sequence Map
    Chr14:16365179-16430787 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65609 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TOP2B, topoisomerase (DNA) II beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP2B, topoisomerase (DNA) II beta
    Orthology source: HomoloGene
  • Synonyms
    top2beta, TOPIIB
  • Links
    NCBI Gene ID: 7155
    neXtProt AC: NX_Q02880

  • Chr Location
    3p24; chr3:25597905-25664905 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035016 VEGA Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
transcript OTTMUST00000089034 VEGA | MGI Sequence Detail 5660 Not Applicable  
polypeptide OTTMUSP00000048601 VEGA | MGI Sequence Detail 1612 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    319 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016545 DNA topoisomerase 2-beta
  • EC
  • InterPro Domains
    IPR024946 Arginine repressor C-terminal-like domain
    IPR031660 C-terminal associated domain of TOPRIM
    IPR028467 DNA topoisomerase II-beta
    IPR001241 DNA topoisomerase, type IIA
    IPR013759 DNA topoisomerase, type IIA, central domain
    IPR018522 DNA topoisomerase, type IIA, conserved site
    IPR013760 DNA topoisomerase, type IIA-like domain
    IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
    IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
    IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
    IPR012542 DTHCT
    IPR003594 Histidine kinase-like ATPase, C-terminal domain
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR006171 Toprim domain
    IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain
Molecular
Reagents
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  • All nucleic 278
    cDNA 277
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-15166, MGD-MRK-15170, MGI:2441960
References
more
  • Summaries
    All 52
    Developmental Gene Expression 9
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
  • Latest
    J:207483 Li Y, et al., Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3(2):172-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory