About   Help   FAQ
Top2b Gene Detail
Summary
  • Symbol
    Top2b
  • Name
    topoisomerase (DNA) II beta
  • Synonyms
    D230016L12Rik, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98791
    NCBI Gene: 21974
  • Gene Overview
    MyGene.info: TOP2B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:16365206-16430787 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98791
protein coding gene Chr14:16365179-16435462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021016
protein coding gene Chr14:9000401-9069478 (+)
A/J MGP_AJ_G0020964
protein coding gene Chr14:8734664-8799339 (+)
AKR/J MGP_AKRJ_G0020941
protein coding gene Chr14:8960889-9029203 (+)
BALB/cJ MGP_BALBcJ_G0020967
protein coding gene Chr14:8765027-8833871 (+)
C3H/HeJ MGP_C3HHeJ_G0020751
protein coding gene Chr14:9068706-9135950 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021400
protein coding gene Chr14:9257776-9327048 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018969
protein coding gene Chr14:9346710-9411742 (+)
CAST/EiJ MGP_CASTEiJ_G0020274
protein coding gene Chr14:8936531-9020711 (+)
CBA/J MGP_CBAJ_G0020717
protein coding gene Chr14:9672557-9749255 (+)
DBA/2J MGP_DBA2J_G0020841
protein coding gene Chr14:8664021-8731735 (+)
FVB/NJ MGP_FVBNJ_G0020823
protein coding gene Chr14:8499199-8564886 (+)
LP/J MGP_LPJ_G0020916
protein coding gene Chr14:9052530-9120824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020849
protein coding gene Chr14:9548120-9623690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021433
protein coding gene Chr14:8835925-8902935 (+)
PWK/PhJ MGP_PWKPhJ_G0020025
protein coding gene Chr14:8689580-8756141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019846
protein coding gene Chr14:9056463-9125774 (+)
WSB/EiJ MGP_WSBEiJ_G0020331
protein coding gene Chr14:8881198-8951682 (+)



Homology
more
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    top2beta, TOPIIB
  • Links
    NCBI Gene ID: 7155
    neXtProt AC: NX_Q02880
    UniProt: Q02880

  • Chr Location
    3p24.2; chr3:25597905-25664936 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21974 NCBI Gene Model | MGI Sequence Detail 65582 C57BL/6J ±  kb
    transcript NM_009409 RefSeq | MGI Sequence Detail 5652 C57BL/6  
    polypeptide Q64511 UniProt | EBI | MGI Sequence Detail 1612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016545 DNA topoisomerase 2-beta
    • EC
    • InterPro Domains
      IPR031660 C-terminal associated domain of TOPRIM
      IPR034157 DNA topoisomerase 2, TOPRIM domain
      IPR001241 DNA topoisomerase, type IIA
      IPR018522 DNA topoisomerase, type IIA, conserved site
      IPR013760 DNA topoisomerase, type IIA-like domain superfamily
      IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
      IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
      IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
      IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
      IPR012542 DTHCT
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR020568 Ribosomal protein S5 domain 2-type fold
      IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
      IPR006171 TOPRIM domain
      IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 280
      cDNA 278
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15166, MGD-MRK-15170, MGI:2441960
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
    • Latest
      J:274904 Oury J, et al., MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses. J Cell Biol. 2019 May 6;218(5):1686-1705

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory