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Top2b Gene Detail
Summary
  • Symbol
    Top2b
  • Name
    topoisomerase (DNA) II beta
  • Synonyms
    D230016L12Rik, Top-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98791
    NCBI Gene: 21974
  • Gene Overview
    MyGene.info: TOP2B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:16365179-16430787 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65609 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP2B, DNA topoisomerase II beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    top2beta, TOPIIB
  • Links
    NCBI Gene ID: 7155
    neXtProt AC: NX_Q02880
    UniProt: Q02880

  • Chr Location
    3p24.2; chr3:25597905-25664936 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035016 VEGA Gene Model | MGI Sequence Detail 65609 C57BL/6J ±  kb
    transcript OTTMUST00000089034 VEGA | MGI Sequence Detail 5660 Not Applicable  
    polypeptide OTTMUSP00000048601 VEGA | MGI Sequence Detail 1612 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      319 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016545 DNA topoisomerase 2-beta
    • EC
    • InterPro Domains
      IPR031660 C-terminal associated domain of TOPRIM
      IPR034157 DNA topoisomerase 2, TOPRIM domain
      IPR001241 DNA topoisomerase, type IIA
      IPR018522 DNA topoisomerase, type IIA, conserved site
      IPR013760 DNA topoisomerase, type IIA-like domain superfamily
      IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
      IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
      IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
      IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
      IPR012542 DTHCT
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR020568 Ribosomal protein S5 domain 2-type fold
      IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
      IPR006171 TOPRIM domain
      IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
    Molecular
    Reagents
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    • All nucleic 278
      cDNA 277
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15166, MGD-MRK-15170, MGI:2441960
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:10100 Deffie AM, et al., Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells [published erratum appears in Cancer Res 1990 Jan 15;50(2):449]. Cancer Res. 1989 Dec 15;49(24 Pt 1):6879-82
    • Latest
      J:255262 Yu C, et al., CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017 Aug 1;20(5):1161-1172

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory