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Tnp1
Gene Detail
Symbol

Name
ID
Tnp1
transition protein 1
MGI:98784
Synonyms
Stp-1, Tp-1, TP1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr1:73015074-73015909 bp, - strand
From VEGA annotation of GRCm38

  836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137222  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: TNP1
Protein SuperFamily: spermatid transition protein 1
Gene Tree: Tnp1

Human
homologs
TNP1, transition protein 1 (during histone to protamine replacement)
Orthology source: HGNC

IDs:
NCBI Gene ID: 7141
neXtProt AC: NX_P09430

Human Synonyms: TP1

Human Chr (Location): 2q35-q36; chr2:216859458-216860059 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
A portion of male homozygous null mice are infertile, exhibting defects in spermatogenesis and sperm motility.
 
Interactions
Tnp1 interacts with 91 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, chromatin remodeling, ...
Component chromosome, male germ cell nucleus, ...
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (3)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) Genomic(1) cDNA(71) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000048231 (Evidence)
Ensembl Gene Model ENSMUSG00000026182 (Evidence)
Entrez Gene 21958 (Evidence)
UniGene 425024
DFCI TC1576240, TC1727863
DoTS DT.101330418, DT.487237
NIA Mouse Gene Index U021465
Consensus CDS Project CCDS35611.1
International Mouse Phenotyping Consortium Status Tnp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048231 VEGA Gene Model | MGI Sequence Detail 836 C57BL/6J ±  kb
transcript OTTMUST00000123813 VEGA | MGI Sequence Detail 437 Not Applicable 
polypeptide OTTMUSP00000067509 VEGA | MGI Sequence Detail 55 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001319 Nuclear transition protein 1
InterPro IPR020062 Nuclear transition protein 1, conserved site
Protein Ontology PR:000016511 spermatid nuclear transition protein 1
References
(Earliest) J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
(Latest) J:204898 Akiyama K, et al., A mutation in the nuclear pore complex gene Tmem48 causes gametogenesis defects in skeletal fusions with sterility (sks) mice. J Biol Chem. 2013 Nov 1;288(44):31830-41
All references(61)
Other
accession IDs
MGD-MRK-14634, MGD-MRK-15159, MGD-MRK-15173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory