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Tnp1 Gene Detail
Summary
  • Symbol
    Tnp1
  • Name
    transition protein 1
  • Synonyms
    Stp-1, Tp-1, TP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98784
    NCBI Gene: 21958
  • Gene Overview
    MyGene.info: TNP1
Location & Maps
more
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    TNP1, transition protein 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    TNP1, transition protein 1
    Orthology source: HGNC
  • Synonyms
    TP1
  • Links
    NCBI Gene ID: 7141
    neXtProt AC: NX_P09430

  • Chr Location
    2q35-q36; chr2:216859458-216860059 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tnp1
  • Incidental Mutations
    APF
A portion of male homozygous null mice are infertile, exhibting defects in spermatogenesis and sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048231 VEGA Gene Model | MGI Sequence Detail 836 C57BL/6J ±  kb
transcript OTTMUST00000123813 VEGA | MGI Sequence Detail 437 Not Applicable  
polypeptide OTTMUSP00000067509 VEGA | MGI Sequence Detail 55 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016511 spermatid nuclear transition protein 1
  • InterPro Domains
    IPR001319 Nuclear transition protein 1
    IPR020062 Nuclear transition protein 1, conserved site
Molecular
Reagents
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  • All nucleic 74
    Genomic 1
    cDNA 71
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14634, MGD-MRK-15159, MGD-MRK-15173
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
  • Latest
    J:227136 Shawlot W, et al., Rfx2 is required for spermatogenesis in the mouse. Genesis. 2015 Aug 6;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory