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Tnni3
Gene Detail
 Symbol
Name
ID
Tnni3
troponin I, cardiac 3
MGI:98783
Synonyms cardiac troponin I, cTnI, Tn1
Feature Type protein coding gene
Genetic Map
Chromosome 7
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:4518305-4524229 bp, - strand
From VEGA annotation of GRCm38

  5925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tnni3

Human
homologs
Human Homolog TNNI3, troponin I type 3 (cardiac)
NCBI Gene ID 7137
neXtProt AC  NX_P19429
Human Synonyms  CMD1FF, CMD2A, CMH7, cTnI, RCM1, TNNC1
Human Chr (Location)  19q13.4; chr19:55151767-55157732 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human TNNI3
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
 
Mice lacking both functional copies of this gene die of acute heart failure.
 
Phenotype Images(1)
Interactions
Tnni3 interacts with 11 markers (Mir29b-1, Mir29b-2, Mir185, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cardiac muscle contraction, cellular calcium ion homeostasis, ...
Component contractile fiber, cytoplasm, ...
Function actin binding, calcium channel inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (131)    Tissues (100)    Images (30)
Theiler Stages: 20, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 123
Northern blot 2
Western blot 1
RT-PCR 2
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) Genomic(5) cDNA(82) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027089 (Evidence)
Ensembl Gene ModelENSMUSG00000035458 (Evidence)
Entrez Gene21954 (Evidence)
UniGene27674
DFCITC1575964
DoTSDT.493081
NIA Mouse Gene IndexU028086
PDB2JPW
Consensus CDS ProjectCCDS39736.1
International Mouse Knockout Project StatusTnni3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027089 VEGA Gene Model | MGI Sequence Detail 5925 C57BL/6J ±  kb
transcript OTTMUST00000066983 VEGA | MGI Sequence Detail 912 Not Applicable 
polypeptide OTTMUSP00000033644 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001978 Troponin
InterPro IPR021666 Troponin I residues 1-32
Protein Ontology PR:000016506 troponin I, cardiac muscle
References (Earliest) J:16384 Ausoni S, et al., Structure and regulation of the mouse cardiac troponin I gene. J Biol Chem. 1994 Jan 7;269(1):339-46
(Latest) J:207643 Kruithof BP, et al., Remodeling of the myocardium in early trabeculation and cardiac valve formation; a role for TGFbeta2. Int J Dev Biol. 2013;57(11-12):853-63
All references(116)
Other
accession IDs
MGD-MRK-15158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory