Tnni3
Gene Detail

Symbol Name ID

Tnni3 troponin I, cardiac 3 MGI:98783

Synonyms

cardiac troponin I, cTnI, Tn1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr7:4518305-4524229 bp, - strand From VEGA annotation of GRCm38   5925 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tnni3

Human homologs

Human Homolog		TNNI3, troponin I type 3 (cardiac)
NCBI Gene ID		7137
neXtProt AC		NX_P19429
Human Synonyms		CMD1FF, CMD2A, CMH7, cTnI, RCM1, TNNC1
Human Chr (Location)		19q13.4; chr19:55663135-55669100 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human TNNI3

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(3)
 

Mice lacking both functional copies of this gene die of acute heart failure.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cardiac muscle contraction, cellular calcium ion homeostasis, ...
Component	contractile fiber, cytoplasm, ...
Function	actin binding, calcium channel inhibitor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (131)    Tissues (100)    Images (30)
Theiler Stages: 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	123
Northern blot	2
Western blot	1
RT-PCR	2

cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(91) Genomic(5) cDNA(82) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027089 (Evidence)
Ensembl Gene Model	ENSMUSG00000035458 (Evidence)
Entrez Gene	21954 (Evidence)
UniGene	27674
DFCI	TC1575964
DoTS	DT.493081
NIA Mouse Gene Index	U028086
PDB	2JPW
Consensus CDS Project	CCDS39736.1
International Mouse Knockout Project Status	Tnni3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027089	VEGA Gene Model | MGI Sequence Detail	5925	C57BL/6J
transcript	OTTMUST00000066983	VEGA | MGI Sequence Detail	912	Not Applicable
polypeptide	OTTMUSP00000033644	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(63 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001978	Troponin
InterPro	IPR021666	Troponin I residues 1-32
Protein Ontology	PR:000016506	troponin I, cardiac muscle

References

(Earliest) J:16384 Ausoni S, et al., Structure and regulation of the mouse cardiac troponin I gene. J Biol Chem. 1994 Jan 7;269(1):339-46
(Latest) J:190992 Harmelink C, et al., Myocardial Mycn is essential for mouse ventricular wall morphogenesis. Dev Biol. 2013 Jan 1;373(1):53-63
All references(108)

Other accession IDs

MGD-MRK-15158