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Tnni3
Gene Detail
Symbol

Name
ID
Tnni3
troponin I, cardiac 3
MGI:98783
Synonyms
cardiac troponin I, cTnI, Tn1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:4518305-4524229 bp, - strand
From VEGA annotation of GRCm38

  5925 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:309  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: TNNI3
Gene Tree: Tnni3

Human
homologs
TNNI3, troponin I type 3 (cardiac)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7137
neXtProt AC: NX_P19429

Human Synonyms: CMD1FF, CMD2A, CMH7, cTnI, RCM1, TNNC1

Human Chr (Location): 19q13.4; chr19:55151767-55157732 (-)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human TNNI3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from CvDC )
 
Mice lacking both functional copies of this gene die of acute heart failure.
 
Phenotype Images(1)
Interactions
Tnni3 interacts with 11 markers (Mir29b-1, Mir29b-2, Mir185, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cardiac muscle contraction, cellular calcium ion homeostasis, ...
Component cell, contractile fiber, ...
Function actin binding, calcium channel inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (131)    Tissues (101)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 123
Northern blot 2
Western blot 1
RT-PCR 2
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnni3    NEW 
Molecular
reagents
All nucleic(91) Genomic(5) cDNA(82) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027089 (Evidence)
Ensembl Gene Model ENSMUSG00000035458 (Evidence)
Entrez Gene 21954 (Evidence)
UniGene 27674
DFCI TC1575964
DoTS DT.493081
NIA Mouse Gene Index U028086
PDB 2JPW
Consensus CDS Project CCDS39736.1
International Mouse Phenotyping Consortium Status Tnni3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027089 VEGA Gene Model | MGI Sequence Detail 5925 C57BL/6J ±  kb
transcript OTTMUST00000066983 VEGA | MGI Sequence Detail 912 Not Applicable 
polypeptide OTTMUSP00000033644 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001978 Troponin
InterPro IPR021666 Troponin I residues 1-32
Protein Ontology PR:000016506 troponin I, cardiac muscle
References
(Earliest) J:16384 Ausoni S, et al., Structure and regulation of the mouse cardiac troponin I gene. J Biol Chem. 1994 Jan 7;269(1):339-46
(Latest) J:221709 Wei H, et al., A dominantly negative mutation in cardiac troponin I at the interface with troponin T causes early remodeling in ventricular cardiomyocytes. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C338-48
All references(124)
Other
accession IDs
MGD-MRK-15158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory