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Tnni3 Gene Detail
Summary
  • Symbol
    Tnni3
  • Name
    troponin I, cardiac 3
  • Synonyms
    cardiac troponin I, cTnI, Tn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98783
    NCBI Gene: 21954
  • Gene Overview
    MyGene.info: TNNI3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4518305-4522718 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.61 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98783
protein coding gene Chr7:4518305-4524229 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031548
protein coding gene Chr7:1438215-1444604 (-)
A/J MGP_AJ_G0031523
protein coding gene Chr7:1437782-1443576 (-)
AKR/J MGP_AKRJ_G0031452
protein coding gene Chr7:1515766-1521487 (-)
BALB/cJ MGP_BALBcJ_G0031531
protein coding gene Chr7:1504173-1510095 (-)
C3H/HeJ MGP_C3HHeJ_G0031251
protein coding gene Chr7:1476400-1483389 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031991
protein coding gene Chr7:1470755-1477017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029115
protein coding gene Chr7:1207326-1213268 (-)
CAST/EiJ MGP_CASTEiJ_G0030615
protein coding gene Chr7:1415390-1422433 (-)
CBA/J MGP_CBAJ_G0031209
protein coding gene Chr7:1667136-1672871 (-)
DBA/2J MGP_DBA2J_G0031368
protein coding gene Chr7:1400837-1406590 (-)
FVB/NJ MGP_FVBNJ_G0031320
protein coding gene Chr7:1383742-1389887 (-)
LP/J MGP_LPJ_G0031453
protein coding gene Chr7:1530081-1535845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031359
protein coding gene Chr7:1601647-1609035 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032021
protein coding gene Chr7:1416412-1423267 (-)
PWK/PhJ MGP_PWKPhJ_G0030343
protein coding gene Chr7:1586892-1593272 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030168
protein coding gene Chr7:1474200-1482542 (-)
WSB/EiJ MGP_WSBEiJ_G0030710
protein coding gene Chr7:1432280-1440049 (-)



Homology
more
  • Human Ortholog
    TNNI3, troponin I3, cardiac type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNNI3, troponin I3, cardiac type
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMD1FF, CMD2A, CMH7, cTnI, RCM1, TNNC1
  • Links
    NCBI Gene ID: 7137
    neXtProt AC: NX_P19429
    UniProt: P19429

  • Chr Location
    19q13.42; chr19:55151767-55157732 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Tnni3 mouse models; 4 with human TNNI3 associations

Human Disease Mouse Models
      
IDs
View 5 models
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 8 alleles in 5 genetic backgrounds
    42 phenotypes from multigenic genotypes
    1 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice lacking both functional copies of this gene die of acute heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21954 NCBI Gene Model | MGI Sequence Detail 4414 C57BL/6J ±  kb
    transcript NM_009406 RefSeq | MGI Sequence Detail 925 C57BL/6  
    polypeptide P48787 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 5
      cDNA 83
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15158
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 84
      Diseases 7
      Gene Ontology 12
      Phenotypes 34
    • Earliest
      J:16384 Ausoni S, et al., Structure and regulation of the mouse cardiac troponin I gene. J Biol Chem. 1994 Jan 7;269(1):339-46
    • Latest
      J:264144 Eley L, et al., A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice. Elife. 2018 Jun 29;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory