Phenotypes Associated with This Genotype

Genotype
MGI:5910505

• Allelic Composition: Tg(Myh6-Tnni3*L184)#Rste/0
• Genetic Background: B6.Cg-Tg(Myh6-Tnni3*L184)#Rste

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart weight ( J:161911 )

• heart-to-body weight ratio is decreased in 6 month old mice

• however, hearts do not exhibit hypertrophy

abnormal myocardial fiber physiology ( J:161911 )

• cardiac myofibrils develop higher maximum force per cross-sectional area due to enhanced passive force and calcium-induced force amplitude

• myofibrils exhibit an increase in calcium sensitivity of force development and contraction

• the Hill-coefficient, reflecting overall cooperativity of the force-pCa relation is reduced in myofibrils

• cardiac myofibrils exhibit spontaneous oscillatory contractions of sarcomeres

• overall relaxation process is delayed and slower in cardiac myofibrils

• myofibrils show a decrease in the switch-off kinetics of troponin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 7		DOID:0110313	OMIM:613690	J:161911